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We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing mode
I prove a mass transference principle for general shapes, similar to a recent result by H. Koivusalo and M. Rams. The proof relies on Vitali's covering lemma and manipulations with Riesz energies. The main novelty is that it is proved that the obtained limsup-set belongs to the classes of sets with large intersections, as defined by K. Falconer. This has previously not been proved for as general s
This article addresses overnight guest hosting, which is a widespread solidarity practice among rural-to-urban migrants in Turkey. The fieldwork, based on in-depth interviews with 28 first-generation migrant women, reveals that it was mostly the young migrant women who shouldered hosting tasks as gendered unpaid work, which deepen their time poverty and reinforce their dependence on family. The an
Aim: Risk of treatment-related life-threatening toxicity is high in childhood acute myeloid leukaemia (AML), and access to intensive care units (ICU) is crucial. We explored the ICU admission rate and outcome after intensive care in childhood AML in Sweden. Methods: Patients diagnosed between 2008 and 2016 were identified from the Swedish Childhood Cancer Registry (SCCR), a national quality regist
Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD patholo
To clarify the misfire mechanism is important for stabilizing combustion in partially premixed combustion (PPC) under low load. Fuel-tracer planar laser-induced fluorescence (PLIF), formaldehyde PLIF, flame and OH* natural luminosity imaging were utilized to qualify the local equivalence ratio, low-temperature reaction and the high-temperature flame features in an optical engine. Results show that
Background: This pilot study aims to test the usability of the iACTwithPain platform, an online ACT-based intervention for people with chronic pain, to obtain information on which intervention and usability aspects need improvement and on expected retention rates. Methods: Seventy-three Portuguese women with chronic pain were invited to complete the first three sessions of the iACTwithPain interve
In Sweden there are a great number of neo-gothic churches built in brick masonryaround 1870-1910. They are constructed as massive masonry walls with façadebricks attached to a core of massive red bricks. In the majority of these churchesthere is a presence of sodium sulphate causing salt damages. The source of the salts is known to be the red masonry bricks and the damage occurs both internally an
The European Union has a low-carbon roadmap that aims at reducing greenhouse gas emissions toprevent further climate change and achieve climate-neutrality by 2050. Many of the historical buildings that wehave today will still be around in 2050. Hence, there is a need to improve their energy performance. A way to dothis is to use hemp-lime as a material for renovation. Hemp shiv, the woody core par
Firekite is a synchronous stream cipher using a pseudo-random number generator (PRNG) whose security is conjectured to rely on the hardness of the Learning Parity with Noise (LPN) problem. It is one of a few LPN-based symmetric encryption schemes, and it can be very efficiently implemented on a low-end SoC FPGA. The designers, Bogos, Korolija, Locher and Vaudenay, demonstrated appealing properties
Microbial growth often thrives in humid conditions, at high relative humidity. Moulds are complex organisms; many types of mould are able to survive strong variations in humidity and temperature, such as those on building façades. For some building materials a critical relative humidity is determined, which functions as a theoretical threshold; at this (or lower) relative humidity microbial growt
The study of healthy human aging is important for shedding light on the molecular mechanisms behind aging to promote well-being and to possibly predict and/or avoid the development of age-related disorders such as atherosclerosis and diabetes. Herein, we have employed an untargeted mass spectrometry-based approach to study age-related protein changes in a healthy Sicilian plasma cohort including l
Animal species differ considerably in their ability to fight off infections. Finding the genetic basis of these differences is not easy, as the immune response is comprised of a complex network of proteins that interact with one another to defend the body against infection. Here, we used population- and comparative genomics to study the evolutionary forces acting on the innate immune system in nat
Background: Cervical cancer is a public health challenge despite the available free screening service in Ethiopia. Early screening for cervical cancer significantly improves the chances of successful treatment of pre-cancers and cancers among women of reproductive age. Therefore, this study aimed to assess the uptake of screening and identify the factors among women of reproductive age. Methods: A
A Circular Economy (CE) constitutes one pathway towards realising sustainable productionand consumption. Here, the repair of broken products (compared to replacement) consti-tutes an important strategy to keep products in the economy for longer, thereby reducingwaste, as well as the need to extract resources and emit pollution in the manufacture of areplacement product. In today’s world, repair do
Background Systemic lupus erythematosus (SLE) is a complex disease characterized by autoimmunity toward apoptotic cells, excessive amounts of circulating immune complexes, and complement activation. A decreased platelet size has been observed in SLE and their nonhemostatic functions may play an active role in the disease. The main objective of this study was to find clues that could explain their
In 2017, the Danish parliament discussed prayer rooms at educational institutions in a broadly publicised controversy. The debate followed a series of issues arising from such institutions’ changing demography, resulting in increased Muslim presence. Beneath the public and parliamentary debate in 2017, civil servants in ministries and educational institutions became highly engaged in negotiating w
Background: Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) coculture model to study the role of mechanical injury and inflammation in the initiation of post-traumatic osteoarthritis (PTOA)-like disease. Methods: Osteochondral
