Mucin-1 has proven to be a suitable target for antibody-based diagnosis and therapy of certain tumours, but no appropriate human antibody or antibody fragment displaying slow dissociation rate kinetics against this target is available. Since a rapid dissociation character prevents an antibody fragment from remaining at the site of the antigen, this fact may prevent the successful application of a

Leflunomide is a low molecular weight immunosuppressive drug which inhibits the enzymes dehydroorotate dehydrogenase and protein tyrosine kinase, both of which are important components in the immune response. As the mechanisms of action of leflunomide and tacrolimus are different, we postulated an additive or synergistic effect of the two drugs and investigated the effects of leflunomide alone, or

Materialdata för de vanligaste byggnadsmaterialen presenteras. Materialens egenskaper redovisas som funktion av den relativa fuktigheten och kan användas för att beräkna fukttransport i konstruktioner. Skriften innehåller också exempel på hur fuktdata kan användas i beräkningar samt sambanden mellan olika fukttransportkoefficienter

Abstract in Danish I de industrialiserede lande har 7-10% af den voksne befolkning astma, og tallet har de seneste årtier været stigende [1]. Lægediagnosticeret astma i Danmark er øget fra 4 til 7-10%, og allergisk rinitis eller kronisk ikkeallergisk rinitis er øget fra 10% til 20-25% over en 20-årig periode [2]. Astma er den hyppigste kroniske sygdom hos unge og unge voksne, og en høj forekomst a

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The aim was to study the psychometric properties of the Swedish version of the Chronic Pain Coping Inventory. The material consisted of a group of 100 subjects recruited from a large population study. Pain status and the absence of pain-related sick leave during the previous year conditioned inclusion. Another group comprised 160 patients on the long-term sick list and who had been referred to a m

Using known results on 4-Engel groups one can see that a 4-Engel group is locally nilpotent if and only if all its 3-generator subgroups are nilpotent. As a step towards settling the question whether all 4-Engel groups are locally nilpotent we show that all 2-generator 4-Engel groups are nilpotent.

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Objective: To estimate the occurrence of hand eczema in hairdressers in Sweden. Methods: The occurrence of hand eczema was estimated in a Swedish longitudinal retrospective cohort study including all female graduates from vocational schools for hairdressers from 1970 to 1995. A stratified sample from the general population acted as controls. A self-administered questionnaire including questions on

The results of a paleomagnetic sampling carried out along two vertical profiles (altogether 19 lava flows, 126 samples) covering the entire stratigraphy of the Talerua Member lavas (similar to 39 Myr old) that outcrop on the island Hareoen are presented and represent some of the youngest volcanism in the West Greenland flood volcanic province. Rock magnetic experiments and microprobe analysis demo

A new Reynolds stress transport model (RSTM) aimed for engineering applications is proposed with consideration of near-wall turbulence. This model employs the Speziale, Sarkar and Gatski (SSG) pressure strain term, the omega equation, and the shear stress transport (SST) model for the shear stresses at the near-wall region (say, y(+) < 30). The models are selected based on the following merits: Th