The fetal to adult switch in hematopoietic stem cell (HSC) behavior is characterized by alterations in lineage output and entry into deep quiescence. Here we identify the emergence of megakaryocyte (Mk) biased HSCs as an event coinciding with this developmental switch. Single-cell chromatin accessibility analysis reveals a ubiquitous acquisition of Mk lineage priming signatures in HSCs during the

Accurate streamflow simulation is crucial for many applications, such as optimal reservoir operation and irrigation. Conceptual techniques employ physical ideas and are suitable for representing the physics of the hydrologic model, but they might fail in competition with their more advanced counterparts. In contrast, deep learning (DL) approaches provide a great computational capability for stream

The refusal to shake hands with a female reporter by a Muslim politician from the Miljöpartiet resulted in a controversy in Sweden. Together with a number of court cases, it revealed a disparity between the established judicial line and the views of the general public. The Swedish controversy received a response from Denmark, where the ruling coalition introduced new citizenship legislation with a

BackgroundAlthough preterm birth predisposes for cardiovascular disease, recent studies in children indicate normal blood pressure and arterial stiffness. This prospective cohort study therefore assessed blood pressure and arterial stiffness in adolescents born very preterm due to verified fetal growth restriction (FGR).MethodsAdolescents (14 (13–17) years; 52% girls) born very preterm with FGR (p

Primary Objective: Traumatic brain injury (TBI) and sports-related concussion (SRC) may result in chronic functional and neuroanatomical changes. We tested the hypothesis that neuroimaging findings (cerebral blood flow (CBF), cortical thickness, and 1H-magnetic resonance (MR) spectroscopy (MRS)) were associated to cognitive function, TBI severity, and sex. Research Design: Eleven controls, 12 athl

The COVID-19 pandemic had harsh consequences on human health and society across the globe. In addition to health effects, the pandemic also influenced people’s values, concerns, and ethics due to lockdowns and general limitations in societal activities. In this study, we examined changes in the relationship between people and nature caused by COVID-associated stress, as well as its consequences on

Cross-laminated timber (CLT) floors with supplementary layers or floating floors comprise a common solution in new multistory timber structures. However, bare CLT components provide poor sound insulation, especially in low frequencies during structure-borne sound propagation. Thus, floor configurations in wooden buildings deploy more layers for improved acoustic behavior. Twelve contemporary CLT f