Airway hyperreactivity (AHR) is a major feature of asthmatic and inflammatory airways. Cigarette smoke exposure, and bacterial and viral infections are well-known environmental risk factors for AHR, but knowledge about the underlying molecular mechanisms on how these risk factors lead to the development of AHR is limited. Activation of intracellular mitogen-activated protein kinase (MAPK)/nuclear

We investigate the rotational response of both nondipolar and dipolar Bose-Einstein condensates confined in an annular potential via minimization of the energy in the rotating frame. For the nondipolar case we identify certain phases which are associated with different vortex configurations. For the dipolar case, assuming that the dipoles are aligned along some arbitrary and tunable direction, we

Stochastic optimal power flow can provide the system operator with adequate strategies for controlling the power flow to maintain secure operation under stochastic parameter variations. One limitation of stochastic optimal power flow has been that only steady-state variable limits have been used as security constraints. In many systems voltage stability and small-signal stability also play an impo

The plant respiratory chain contains several pathways which bypass the energy-conserving electron transport complexes I, III, and IV. These energy-bypasses, including type II NAD(P)H dehydrogenases and the alternative oxidase (AOX), may have a role in redox-stabilisation and regulation, but current evidence is inconclusive. Using RNA interference, we generated Arabidopsis thaliana plants simultane

Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by

To be able to disseminate knowledge about maritime safety culture and safety management to different actors in the Swedish maritime sector, a didactic design was developed and evaluated. The didactic design includes an interactive scenario-based module and a teacher’s guide and is based on a model for experience-based learning that connects theory and practice by a cyclic approach. Students at up

Because of their small electromagnetic corrections, the isospin-breaking decays n -> 3 pi seem to be good candidates for extracting isospin-breaking parameters similar to(m(d) - m(u)). This task is unfortunately complicated by large chiral corrections and the discrepancy between the experimentally measured values of the Dalitz parameters describing the energy dependence of the amplitudes of these

The aim of this article is to apply elements of contemporary social theory to the major theoretical, methodological, and ideological divisions across political psychology and to consider both the origins and the impact of a range of theories and models. In so doing, we clarify some of the complexity surrounding the discursive and cultural origins of political psychology. On the basis of this analy

It has been suggested that physical or social activity is associated with fewer sleep disturbances among elderly people. Women report more sleep disturbances than men, which could indicate a variation in activity patterns between the genders. The aim of this study was to investigate associations between sleep disturbances and leisure activities in men and women (n = 945) aged ≥60 years in a Swedis

The Skellefte district, northern Sweden, is known for the occurrence of 1.89 Ga Palaeoproterozoic volcanogenic massive sulphide (VMS) deposits. The deposits are hosted by the older part of a volcanosedimentary succession, which was intruded at 1.88-1.86 Ga by multiple phases of the syn-volcanic, early orogenic Jorn intrusive complex (JIC). The oldest phase of the JIC hosts different styles of mine

We report on the first observation of the macroscopic (long-range) phase separation in Si-rich oxide SiOx(x

Embryonic genome activation (EGA) is the first major step towards successful initiation of preimplantation development, which culminates in the formation of implantation-competent embryos. EGA occurs at species-specific embryonic cell stages. In the present work, EGA was identified for buffalo embryos by studying the development rate of embryos in normal as well as imposed transcription block cond

Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy is in part regulated by these leukocytes; cytotoxic therapies induce mammary epithelial cells to pro

We study the curvature of manifolds which admit a complex-valued submersive harmonic morphism with either, totally geodesic fibers or that is holomorphic with respect to a complex structure which is compatible with the second fundamental form. We also give a necessary curvature condition for the existence of complex-valued harmonic morphisms with totally geodesic fibers on Einstein manifolds.

Acta Geotechnica June 2013, Volume 8, Issue 3, pp 247-263 Localized deformation in intensely fissured clays studied by 2D digital image correlation C. Vitone, G. Viggiani, F. Cotecchia, S. A. Hall … show all 4 hide Citations 368 Downloads 200 Citations 9 Comments » Download PDF (3,181 KB) » View Article Abstract This paper represents a further step in a longstanding research on the influence

Subglacial lakes beneath the Vatnajokull ice cap in Iceland host endemic communities of microorganisms adapted to cold, dark and nutrient-poor waters, but the mechanisms by which these microbes disseminate under the ice and colonize these lakes are unknown. We present new data on this subglacial microbiome generated from samples of two subglacial lakes, a subglacial flood and a lake that was forme

Secondary hyperparathyroidism is a common condition in patients with end-stage renal disease and is associated with osteoporosis and cardiovascular disease. Despite improved medical treatment, parathyroidectomy (PTX) is still necessary for many patients on renal replacement therapy. The aim of this study was to evaluate the effect of PTX on patient survival.