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Structure and function of α-glucan debranching enzymes

α-Glucan debranching enzymes hydrolyse α-1,6-linkages in starch/glycogen, thereby, playing a central role in energy metabolism in all living organisms. They belong to glycoside hydrolase families GH13 and GH57 and several of these enzymes are industrially important. Nine GH13 subfamilies include α-glucan debranching enzymes; isoamylase and glycogen debranching enzymes (GH13_11); pullulanase type I

The topography of mutational processes in breast cancer genomes

Somatic mutations in human cancers show unevenness in genomic distribution that correlate with aspects of genome structure and function. These mutations are, however, generated by multiple mutational processes operating through the cellular lineage between the fertilized egg and the cancer cell, each composed of specific DNA damage and repair components and leaving its own characteristic mutationa

Coastal Erosion in Mozambique : Governing Processes and Remedial Measures

Coastal erosion in Mozambique: Governing processes and remedial measures. Mozambique's 2800-km-long coastline comes with associated vulnerability to coastal erosion, their processes, and resulting evolution. In fact, coastal erosion has been identified as a dominant phenomenon in the Mozambican coastal system. It is driven by a combination of natural processes and anthropogenic actions. Despite th