Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Here, using congenic strains from the diabetic GK-rat, we identified a 1.4-Mb genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced beta cell exocytosis. In this locus, Adra2a, encoding the alpha2A-adrenergic recep

Recurrent prostate cancer (PCa) remains a major clinical challenge. Invasive and metastatic PCa lesions often exhibit a partial and time-limited response to therapy before the cancer progresses and the patient succumbs to the disease. Despite recent advances in early diagnosis and treatment, approximately one-third of treated patients will relapse and become resistant to currently available treatm

Objective: To investigate the impact of a reminder (i.e., a mailed letter or short telephone call) from the pharmacy to patients, compared with no reminder in a control group, on the pick-up rates of unclaimed e-prescriptions. Method: Patients, with e-prescriptions transmitted to four large community pharmacies in two counties in northern Sweden and remaining unclaimed after 4 weekdays, were rando

PURPOSE: To assess the patient and identify the risk factors for infectious complications in conjunction with urological procedures and suggest a model for classification of the procedures. METHOD: Review of literature, critical analysis of data and tentative model for reducing infectious complications. RESULTS: Risk factors are bound to the patient and to the procedure itself and are associated w

BACKGROUND: Several candidate genes on the short arm of chromosome 6 including the HLA locus, TNF, LTA and AGER could be associated with late diabetic complications. The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications. METHODOLOGY/PRINC

Kulturkrönika om BBC-serien "Sherlock"

Medieval Tønsberg, the church and the hinterland: A survey of the ecclesiastical institutions and their property, especially the land that belonged to the church in Medieval Tønsberg.

En ny typ av undervattenskonstruktion kallad flexibel vall tar tagits fram och provats med framgång i Japan. Den flexibla vallen består av ett gummimembran som fylls med vatten.

The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatc

Inkomstbeskattning av fusion företagen enligt ABL 14:8.

Lake Poopó is a terminal lake of the Bolivian Altiplano, with high salinity and heavy anthropogenic pollution from centuries of extensive mining activity. This study aims to describe how the water quality of groundwater and surface water system in different subwater-sheds of the Lake Poopó varies with geology and hydrology. Measurements of total dissolved solids (TDS) in wells show groundwater bec