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INTRODUCTION: Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether markers of CVD and inflammation are associated with AD-related diagnostic progression in people with DS. METHODS: We included 149 participants (mean age [SD] = 44.

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow-up 8.0 years, SD 3.1). Multimodal magnetic reson

Aims Cardiac allograft vasculopathy (CAV) is a significant complication that contributes to both morbidity and mortality after heart transplantation. The aim of this study was to (i) assess if quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion could detect different stages of CAV and (ii) establish a myocardial perfusion reserve (MPR) cut-off for significant CAV. Methods and

Anthropogenic noise is an increasing form of environmental change that alters natural soundscapes. Human activities, including road traffic, have led to a notable increase in ambient noise, which may impair how animals use their sensory systems to fulfill vital activities. Previous experiments suggest that noise affects the hunting behavior of nocturnal predators, but it is still scarcely document

This thesis aimed to analyze how the Taiwanese government narrates the Russo-Ukrainian war and why, regarding their foreign policy efforts and the articulation of a Taiwanese national identity. Twenty-nine articles from the Taiwanese Office of the President published between January and August 2022 were examined. In its discourse, Taiwan drew a parallel with the situation in Ukraine, portraying bo

Environmental stress can alter not only trait means but also trait variances - an often-overlooked evolvable feature with ecological and evolutionary relevance. We examine how dietary stress affects both the mean and variance of morphological and reproductive traits across two generations in clonal Daphnia. We manipulated maternal and offspring environments with high- (algae) or low-quality (cyano

Reflection seismic data were acquired in the Sudret area of Gotland between 6 and 13 November 2023. Objectives of the survey were to obtain images of the subsurface down to the Precambrian basement in the vicinity of two cored boreholes that had been drilled earlier down to about 800 m. The seismic profiles were positioned to provide a better understanding of the sedimentary strata and local struc

The Kant Walks, 2003–2004 - Photographic seriesJoachim Koester’s series The Kant Walks explores the physical paths once walked by philosopher Immanuel Kant in 18th-century Königsberg (now Kaliningrad) Bydocumenting these routes, Koester uncovers physical layers of history, abandoned settlements, and forgotten places His photographs – often depicting empty,decaying urban landscapes – pose the quest

The molecular chaperone αB-crystallin is a small heat shock protein that inhibits the aggregation of, among others, Aβ42 and α-synuclein. These proteins are major hallmarks of Alzheimer's and Parkinson's disease, respectively. In order to understand the mechanism with which αB-crystallin performs its chaperone function it is essential to characterize its self-assembly in terms of aggregate size di

For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in randomised controlled trials. However, the results from phase 3 randomised controlled trials of anti-β amyloid monoclonal antibodies are interpreted in different ways, with some experts supporting a clini

Subungual epidermoid inclusions (SEI) are small epithelial inclusions, sometimes solid but mostly with central keratinization of the onycholemmal type without a granular layer. Exceptionally, they become large enough to produce symptoms such as pain or swelling of the nail bed, resulting in subungual keratosis, onycholysis, or a dystrophic nail plate. Herein, we report a further case of SEI in a f

Scientists may benefit from implementing interdisciplinary and multi-method approaches when studying loneliness. Loneliness is a complex phenomenon that is influenced by biological, psychological, social, cultural, and political factors. In addition, it also reflects and impacts personal and local experiences as well as broader social forces, thus being both universal and contextual at the same ti

Objectives To investigate the association of diabetes, hypertension and overweight/obesity with physical activity (PA), self-efficacy for pain and self-efficacy for other symptoms before and after a 6- week exercise and education intervention for knee and hip osteoarthritis (OA), and to assess outcome disparities based on metabolic health. Methods Register-based cohort study using the Swedish Oste

Objective Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are globally prevalent chronic diseases that affect millions of individuals in ageing populations. Hip and knee replacements are well established and effective treatments in patients suffering from end-stage OA. Understanding how T2DM influences the outcomes of these surgeries is important for optimising patient care and improving s

Realistic representation of atmospheric aerosol size distribution dynamics in large-scale climate models is important for developing accurate descriptions of aerosol-cloud interactions. Despite the dynamic nature of the distributions, which have large seasonal and diurnal changes, model evaluations often focus on the annual median size distribution. Using more comprehensive monthly and diurnal mod

Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a

Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading source of health and social care expenditure for society. Before the advent of biomarkers, post-mortem examination was the only method available to establish a definitive diagnosis.

Background Self-harm is a prevalent health concern among youths, with significant psychosocial impacts on both youths and their parents. The aim of this study is to describe the impact of offspring self-harm on parental work absence. Methods This cohort study included 176 472 mothers and 161833 fathers of 17 726 youths with a first self-harm diagnosis between the years of 2006 and 2016 and 177 260