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Diffuse reflectance spectroscopy (DRS) utilizes white light with a known spectrum, which is guided to the surface of the skin via an optical fiber. As light penetrates into the tissue, photons either scatter or become absorbed where only a fraction of the injected photons manage to escape back from the skin surface. This light is captured by a second fiber and measured with a spectrometer. Dependi

https://www.photoacoustics.lu.se/platform/house-diffuse-reflectance-spectroscopy - 2026-06-21

Hyperspectral imaging has traditionally been employed for environmental monitoring where large swaths of land have been surveyed miles above from air planes. With the capability of resolving minute spectral changes in space, different types of vegetation and soils could be identified over large areas, which has been useful to recognize the prevalence of various crop diseases. Today, the method is

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/hyperspectral-imaging - 2026-06-21

When employing optical characterization of human tissue it is important to obtain proper characteristics of all its constituents that coexist in a complex fashion. This requires that each constituent is isolated and measured independently to determine how it reacts to different wavelengths of light (primarily absorption). Besides the hyperspectral camera, we have a multispectral microscope which e

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/multispectral-microscopy - 2026-06-21

Implement in-house state-of-the-art motion-tracking methods into our novel PAI application and evaluate its performance. During a scan, motion artifacts arise as a result of movements of the operator or the patient, and from breathing and tissue movements. To reduce movements of the operator and patient we have developed a transducer holder and stabilized the patient using a vacuum pillow (Sheikh

https://www.photoacoustics.lu.se/technical-development/motion-tracking - 2026-06-21

A key feature of photoacoustic imaging is its ability to illuminate tissue at multiple wavelengths, and thus record images with a spectral dimension. Spectral imaging allows sensing of intrinsic chromophores that can reveal physiological, cellular and subcellular functions. However, the identification of spectral signatures within images obtained at multiple wavelengths requires spectral unmixing

https://www.photoacoustics.lu.se/technical-development/spectral-unmixing - 2026-06-21

This project focus on evaluating and optimizing photoacoustic (PA) imaging as a method to detect and outline skin tumors. We are investigating the PA spectral signature of different tumor cells to enable automatic measure­ment of the tumor borders, and test the developed method in the clinical setting, ultimately developing PA imaging into a diagnostic tool for skin cancer.   When operating tumors

https://www.photoacoustics.lu.se/clinical-applications/skin-cancer - 2026-06-21

Heart failure is a leading cause of death and hospitalization in Sweden today, with a prevalence of between 200 000 to 300 000 subjects. Heart failure is characterized by increased intracardiac pressures and declining output of blood, representing the end-result of many different etiologies that adversely affect cardiac structure and function. Increasing availability of etiology-specific therapies

https://www.photoacoustics.lu.se/clinical-applications/heart-failure - 2026-06-21

Evaluating tissue heating from near-infrared lasers.   With the rise of biophotonics in medical applications such as photodynamic therapy (PDT), laser induced fluorescence (LIF) and gas in scattering media absorption spectroscopy (GASMAS) the tissue heating properties of lasers in the tissue optical window is an increasingly interesting topic. These wavelengths in the range between 700 and 1100 nm

https://www.photoacoustics.lu.se/technical-development/tissue-heating - 2026-06-21

Lund University  Clinical Center for Spectral and Acoustic Imaging is an interdisciplinary center that have been established at the Faculty of Medicine and the Faculty of Enginering (LTH) at Lund University to ensure a solid platform with the required expertise. Our vision is to make photoacoustics a new clinical diagnostic tool and become world leaders in photoacoustic research. The infrastructur

https://www.photoacoustics.lu.se/welcome-clinical-center-spectral-and-acoustic-imaging - 2026-06-21

Photoacoustic imaging is one of the most promising non-invasive biomedical imaging techniques. It combines laser light and ultrasound to generate high resolution 3D images (resolution 15–40 μm, 2 cm depth) of the tissue structure and molecular composition. The analyzed tissue is irradiated with pulsed laser light, which causes so-called thermoelastic expansion, which in turn generates mechanical w

https://www.photoacoustics.lu.se/platform/photoacoustic-imaging - 2026-06-21

Diffuse reflectance spectroscopy (DRS) utilizes white light with a known spectrum, which is guided to the surface of the skin via an optical fiber. As light penetrates into the tissue, photons either scatter or become absorbed where only a fraction of the injected photons manage to escape back from the skin surface. This light is captured by a second fiber and measured with a spectrometer. Dependi

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/commercial-diffuse-reflectance-spectroscopy - 2026-06-21

https://www.photoacoustics.lu.se/shortcuts - 2026-06-21

This project focuses on evaluating novel imaging techniques for measurement of perfusion and oxygenation in the anterior segment of the eye and the eye muscles during strabismus surgery. By doing this, the risk of anterior ischemia could be calculated and surgical techniques optimized. Strabismus is a state of impaired ocular alignment with a prevalence of 2-4% in the western world. In children, s

https://www.photoacoustics.lu.se/clinical-applications/strabismus-surgery - 2026-06-21

Unsupervised skin tumour delineation using hyperspectral imaging and machine learning. Hyperspectral imaging provides detailed spectral and spatial information of a surface in ways our eyes are not capable of visualizing. We use a custom-made hyperspectral imaging camera from Norsk Elektro Optikk (NEO), capable of providing spectral information between 400-1700 nm. While this allows us to produce

https://www.photoacoustics.lu.se/technical-development/machine-learning - 2026-06-21

Lund University funding for research infrastructure (Lunds Universitetsgemensamma medel för forskningsinfrastuktur)Lund University has allocated funds for university-wide financing of infrastructure. These funds are announced annually by the university joint research committee. Interdisciplinary research environments with special strategic importance for the university are the focus of the call.Th

https://www.photoacoustics.lu.se/funding - 2026-06-21

We use the photoacoustic imaging technology platform to solve clinical problems while developing technology to make this possible. Motion Tracking Machine Learning Spectral Unmixing Spectral Coloring Tissue Heating

https://www.photoacoustics.lu.se/technical-development - 2026-06-21

Pediatric surgery for gastrointestinal and genital malformations The purpose of this project is to develop, evaluate and implement novel bioimaging techniques for monitoring perfusion and oxygenation during pediatric surgery, with regard to congenital anorectal malformations, Hirschsprung’s disease and tumors, and to assess the correlation to postoperative complications in the skin and intestine.

https://www.photoacoustics.lu.se/clinical-applications/pediatric-surgery - 2026-06-21

PhD thesis from the Lund University Photoacoustic Center. The thesis are opened in a new window.Khodaverdi A. Development of Photoacoustic Imaging Techniques Towards Clinical Translation; Lund University; 2025-09-12Hult J. Skin tumor delineation using photoacoustic imaging and hyperspectral imaging; Lund University; 2024-11-22Bunke J. Novel Bioimaging Techniques using Spectral Information for Moni

https://www.photoacoustics.lu.se/dissertations - 2026-06-21

We have a Teledyne FLIR A655sc camera for highly resolved thermal imaging, which allows for non-invasive temperature mapping of tissue. This enables direct feedback of the potentially damaging effects of absorbing too much laser light, which is important for setting guidelines for safe clinical implementation of PAI. Thermal imaging is also useful as a complementary monitoring system for a range o

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/thermography - 2026-06-21

Spectral coloring is a phenomenon that becomes relevant when studying light of different “colors” (wavelengths) propagating through tissue. It is expected that light gets attenuated as it reaches further into the tissue. However, since the absorbing species in the tissue interact with different wavelengths, the spectrum of light that remains to be absorbed at deeper layers will change shape and th

https://www.photoacoustics.lu.se/technical-development/spectral-coloring - 2026-06-21