L-amino acid sensing by CaSR and Physiological Impact on Mice.
After localizing of the extracellular calcium sensing receptor (CaSR) throughout the gastrointestinal tract, free aromatic L-amino acids have been found to act as positive allosteric modulators suggesting the CaSR is a potential mediator in protein digestion. The binding site for L-amino acids in the CaSR is located in the venus flytrap domain (VFD). Point mutations on residue Thr-145 and Ser-170
