Calreticulins- Calcium-Binding Proteins with Functional Diversity and Evolutionary Duality
Calreticulin is a multifunctional protein mainly localized in the endoplasmic reticulum in eukaryotic organisms, except yeasts. The protein comprises three distinct regions: the N-terminal N domain, the C-terminal C domain, and the central P domain, reflecting the functional diversity of calreticulin. The protein has been implicated in over 40 intra- and extracellular processes in mammalian cells,