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Stem cells hold the key to unlocking new advances in modern medicine and transforming human health. At Lund Stem Cell Center we are committed to creating a world where stem cell-based therapies are a reality, providing new treatment options for patients who are today living without a cure. About Lund Stem Cell Center Learn more about who we are and what we do at the Center Leadership Meet the lead
https://www.stemcellcenter.lu.se/about - 2026-07-09
By Tove Smeds - published 22 December 2022 Johan Flygare and Aurélie Baudet, stem cell researchers at Lund University. Photo: Johan Persson. Stem cells programmed to produce insulin in people with type 1 diabetes or to repair the heart muscle after a heart attack. Gene and cell therapies that improve cancer treatments. These new and innovative therapies have the potential to cure, alleviate and tr
https://www.stemcellcenter.lu.se/advanced-treatments-future-are-soon-here - 2026-07-09
By Tove Smeds - published 22 December 2022 Dopamine-producing neurons that researchers from Lund University have grown in the laboratory from human embryonic stem cells. Photo: Agnete Kirkeby. At the end of October 2022, the Swedish Medical Products Agency gave the go-ahead for a clinical trial of the stem cell-based therapy STEM-PD for the treatment of Parkinson’s disease. The cells, generated fr
https://www.stemcellcenter.lu.se/nerve-cells-could-transform-treatment-parkinsons - 2026-07-09
By Tove Smeds - published 22 December 2022 Dolly the sheep determined Filipe Pereira’s future career. The choice was between becoming an architect or a scientist, when one of the world’s most extreme examples of cellular programming sparked his curiosity about the human body. Photo: Johan Persson. By reprogramming tumour cells to become the body’s defenders, Filipe Pereira and his colleagues hope
https://www.stemcellcenter.lu.se/reprogramming-cancer-cells-immune-defenders - 2026-07-09
At the Lund Stem Cell Center, our leaders are distinguished scientists, clinicians, and educators, who bring together their diverse expertise to drive groundbreaking research and education initiatives. With their guidance and support, the Center is well-positioned to continue advancing stem cell research to make stem cell-based therapies a reality. Management Team Meet the team leading and oversee
https://www.stemcellcenter.lu.se/leadership - 2026-07-09
In June 2022, Sofia Bergh started her PhD studies in TNU supervised by Prof. Åsa Petersén. The overall aim of the PhD project is to investigate the cellular and molecular mechanisms of limbic system pathology of Huntington’s disease. Her first original research article is in press titled “Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington’s disease” in Neuropathol
https://www.huntington-research.lu.se/team/sofia-bergh-phd-student - 2026-07-09
Weydt P, Dupuis L and Petersen Å. Handbook of Clinical Neurology 157: 761-775 (2018) Abstract Huntington disease (HD) is a paradigmatic autosomal-dominant adult-onset neurodegenerative disease. Since the identification of an abnormal expansion of a trinucleotide repeat tract in the huntingtin gene as the underlying genetic defect, a broad range of transgenic animal models of the disease has become
https://www.huntington-research.lu.se/thermoregulatory-disorders-huntington-disease - 2026-07-09
Baldo B, Soylu R and Petersén ÅPLoS One 8(12) (2013)AbstractHuntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms whereas recent work has suggested that the hypothalamus might be involved in the metabolic
Bergh S, Gabery S, Tonetto S, Kirik D, Petersén Å and Cheong RY. Neuropathology and Applied Neurobiology. 2023;49(2):e12891. doi:10.1111/nan.12891 [published correction appears in Neuropathol Appl Neurobiol. 2023 Jun;49(3):e12905]. Abstract Background: Early non-motor features including anxiety, depression and altered social cognition are present in Huntington's disease (HD). The underlying neurob
In May 2022, Karin Dalene Skarping started her PhD studies in TNU supervised by Prof. Åsa Petersén. The overall aim of the PhD project is to study genetic mechanisms that may modify the disease course and pathology of Huntington disease. One of her current research projects is aimed to examine associations between germline pathogenic variants in mismatch-repair (MMR) genes and CAG-repeats in HTT,
https://www.huntington-research.lu.se/team/karin-dalene-skarping-phd-student - 2026-07-09
Sofia Hult Lundh1, Nathalie Nilsson1, Rana Soylu1, Deniz Kirik2 and Åsa Petersén1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Human Molecular Genetics 22: 3485-3497 (2013)A
Linda Holmquist Mengelbier is a paediatric cancer researcher who now, in parallel to her cancer effort, has started to work with the neurodegenerative disorders Huntington disease and ALS. Her focus in the cancer field has been on the embryonal pediatric solid tumors neuroblastoma and Wilms tumor. Neuroblastoma is a sympathetic nervous system tumor derived from the neural crest, whereas Wilms tumo
https://www.huntington-research.lu.se/team/linda-holmquist-mengelbier-phd - 2026-07-09
Soylu-Kucharz R, Adlesic N, Davidsson M, Björklund T, Björkqvist M and Petersén Å. bioRxiv 2023.03.04.530949; First published March 4, 2023, https://doi.org/10.1101/2023.03.04.530949 Abstract Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its associatio
Dalene Skarping K, Arning L, Petersén Å, Nguyen HP and Gebre-Medhin S.Sci Rep. 2024;14(1):4300. Published 2024 Feb 21. doi:10.1038/s41598-024-54277-5AbstractDNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional
Lilja Andersson P, Juth N, Petersén Å, Graff C and Edberg AE.Lund University, Sweden.Nursing Ethics 20: 189-199 (2013)AbstractThe aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to und
https://www.huntington-research.lu.se/ethical-aspects-undergoing-predictive-genetic-testing-huntingtons-disease - 2026-07-09
In 2024, Jennifer moved from Sydney, Australia to Lund, Sweden to start her PhD studies at the TNU, supervised by Pof. Åsa Petersén. In utilizing novel AAV-vectors and crossbreeding of animal models, Jennifer’s project aims to elucidate the specific hypothalamic circuitries important for the control of metabolism and emotion, with relevance to Huntington’s Disease, Amyotrophic Lateral Sclerosis an
https://www.huntington-research.lu.se/team/jennifer-oraha-phd-student - 2026-07-09
Lundh SH, Soylu R and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.PLoS ONE 7(12): e51168 (2012).AbstractMetabolic and psychiatric disturbances occur early on in the clinical manifestation of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. Hypot
Hagen N, Lundin S, O'Dell T and Petersén Å.Culture Unbound 4: 537-557 (2012)AbstractModernity has meant a cultural and social differentiation within the western socie- ty, which, according to Jürgen Habermas’ theory on communication, can be seen as a division between different forms of actions that takes place in different realms of the society. By combining Habermas’ notions of lifeworld and sys
https://www.huntington-research.lu.se/better-or-worse-lifeworld-system-and-family-caregiving-chronic-genetic-disease - 2026-07-09
Bergh S, Casadei N, Gabery S, Simonsson O, Duarte JMN, Kirik D, Nguyen HP and Petersén Å.Acta Neuropathologica Communications. 2025;13(1):119. Published 2025 May 27. doi:10.1186/s40478-025-02018-8AbstractTAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregul
Li X, Li S, Li X-J, Nguyen HP, Petersen Å and Pouladi MA.Journal of Huntington’s Disease. 2025;14(3):270-278. doi: 10.1177/18796397251358017. AbstractHuntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Research efforts to understand and treat the disease have historically focused on neuronal pathology, but growing
https://www.huntington-research.lu.se/role-oligodendroglial-dysfunction-huntingtons-disease - 2026-07-09
