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Cholesterol-rich clusters of SNARE (soluble NSF attachment protein receptor) proteins have been implicated as being important for exocytosis. Here we demonstrate the significance of cholesterol for normal biphasic insulin secretion in mouse beta cells by removal of cholesterol from the plasma membrane using methyl-beta-cyclodextrin (MBCD). Maximal inhibition of insulin secretion in static incubati
BACKGROUND: Health-care costs for hand and forearm injuries in young children are poorly documented. We examined costs in 533 children injured years 1996-2003. METHODS: Health-care costs and costs for lost productivity were retrospectively calculated in children from three catchment areas in Sweden. Seven case categories corresponding to alternative prevention strategies were constructed. RESULTS:
AIM: To investigate the association between political trust (an aspect of institutional trust) and self-rated health, taking generalized (horizontal) trust in other people into account. METHODS: The 2004 public health survey in Skåne is a cross-sectional postal questionnaire study answered by 27,963 respondents aged 18-80 years, yielding a 59% response rate. A logistic regression model was used to
In this paper a robust method is presented for the combined design of STATCOM and Power System Stabilizer (PSS) controllers in order to enhance the damping of the low frequency oscillations in power systems. The combined design problems among PSS and STATCOM internal ac and dc voltage controllers has been taken into consideration. The equations that describe the proposed system have been linearize
The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next generation sequencing (NGS) was therefore used to determine all DRB alleles
Doctors are expected to serve the patient in an unbiased and medically accurate manner. Yet, this does not prevent doctors and other medical staff from having pronounced views on whether the patient deserves care. Based on field notes from a cardiology clinic, this contradiction is discussed and analyzed. In directing the spotlight on what circumstances are pointed out by the staff when discussing
OBJECTIVE: Umbilical cord acid-base analysis is fundamental for assessing intrapartum hypoxia. The accuracy of arterial umbilical cord blood lactate, pH and base deficit to reflect a low 5-minute Apgar score and hypoxic ischemic encephalopathy (HIE) stage 2-3 was assessed, and new gestational age-adjusted reference standards were compared with traditional stationary reference values. DESIGN AND SA
This text deals with a very particular dilemma: how should I, a post-linguistic-turn gender historian, deal with the reality that women are constantly excluded from the continuing writing of the past (or are silenced in the history that is played out in front of my eyes) without falling back on the herstory tradition that the majority of us academics say we have left behind? The problem is discuss
An upper bound on the first-event error probability for maximum-likelihood decoding of fixed binary convolutional codes on the binary symmetric channel is derived. The bound is evaluated for rate1/2codes, and comparisons are made with simulations and with the bounds of Viterbi, Van de Meeberg, and Post. In particular, the new bound is significantly better than Van de Meeberg's bound for rates abov
SP har etablerat en databas med 180 rasade eller skadade tak. Det framgår, att det var övervägande stål- och träkonstruktioner, som hade rasat. Endast en skadad betongkonstruktion rapporterades. Byggnadernas ålder spänner över cirka 100 år, men 60 % är uppförda från 1980 och framåt. Taken är förhållandevis flacka. Ca 30 % är lantbruksbyggnader. De dominerande rasorsakerna är dimensioneringsfel och
To evaluate the long term effect on lower extremity function and working capacity after stenting of iliocaval vein segments for acute deep venous thrombosis (DVT) or chronic venous occlusive disease. During a 14 year period from November 1994 to October 2008, 114 patients with median age 36 (interquartile range [IQR], 27-48) years, 72 (63%) women, 72 (63%) with hypercoagulable disorders, with acut
