Oestrogen receptor alpha (ER; gene symbol ESR1) is the most important prognostic and treatment-predictive biomarker in breast cancer. Drugs targeting oestrogen and ER for endocrine therapy of breast cancer include aromatase inhibitors, the selective ER modulator tamoxifen and the selective ER degrader fulvestrant. Tumours can develop resistance to endocrine therapy through several mechanisms, whic

The phenomenon of green inside activism (GIA) is experiencing increasing interest, both in the academic world and in the public debate. GIA is a theoretical concept intended to capture the political agency of public officials who are ideologically committed to green values and work to promote them from within an agency. This article examines the economic implications of GIA from a public choice pe

Heart disease is a significant public health threat, and its burden is increasing worldwide. Recent evidence suggests that dietary pattern is a key modifiable factor for heart disease. Research regarding dietary patterns and heart disease in Bangladesh with their spatial variability is limited. In this study, the spatial variation and relationship between dietary patterns and heart disease among B

As production and supply chains rely on exploitative extraction of nature and labour, consumption levels (resource use) remain one of the main indicators of inequality, across and within national contexts. In times of ongoing climate crisis and rising levels of inequalities, welfare systems face the dual challenge of transforming economies to reduce their reliance on unsustainable industries as we

Blogpost. A personal reflection of starting to supervise students in higher education.

The paper examines three late nineteenth–early twentieth century Pacific Northwest coast objects—a Nuu-chah-nulth kuxmin (bird rattle), a Haida sGaaga (medicine man) figure, and a Kwakwaka’wakw or Wuikinuxv wooden model of a totem pole—from the collections of the Ehlers museum in Haderslev, Denmark. Drawing on multiple sources and epistemologies and structuring the study as a weaving of different

This article considers the 2030 Agenda for Sustainable Development (United Na-tions 2015) and its 17 Sustainable Development Goals (SDGs) in relation to musiceducation and specifically small-group instrumental teaching. Sweden ranks highin democracy indices and was recently judged to be the fourth-most democratic country in the world according to Economist Intelligence (EIU 2022). Nonetheless, the

Preventing and mitigating damage to the surroundings arising from process safety incidents is an important aspect of process safety. Risk-informed or risk-based decision-making are cornerstones in most countries’ regulatory regimes for land-use planning. However, the design and implementation of the regulations vary significantly - from countries that have chosen a highly standardized set of rules

Denna bok syftar till att ge läsaren en bra grund för att sköta löpande bokföring och upprätta bokslut. I boken fokuseras såväl begreppsförståelse, bokföringslogik som konkret bokförings- och bokslutsarbete. Bokförings- och bokslutsarbete relateras till de finansiella rapporter som företag upprättar och som bygger på bokförda belopp. Sammanställning av resultaträkning och balansräkning och analys

Denna övningsbok följer upplägget i faktaboken Redovisning - från bokföring till analys. Övningsboken innehåller ett stort antal övningar med fullständiga lösningsförslag. Lösningarna kompletteras med utförliga kommentarer och förklaringar.Redovisning är en process som omfattar allt från företagets transaktioner och omständigheter, till den analys och användning av företagets redovisningsinformati

Regeringen ger nu stadigt statsbidrag till organisationer som till exempel delar ut matpaket. Men risken att Sverige glider in i en mer oklar socialpolitik för de mest ekonomiskt utsatta, skriver debattörer.The government now provides steady state grants to organizations that, for example, distribute food packages. But debaters warn that Sweden risks slipping into a more unclear social policy for the most economically vulnerable.

Klimatförändringarna förväntas påverka skogar i de tempererade och boreala zonerna och leda till omfattande förändringar i ekosystemens struktur och funktion. Därför behövs analyser av sannolika utfall av olika scenarier av ökad klimatpåverkan på lång sikt, för att förbättra kunskapsunderlaget och stödja beslutsfattande inom skogssektorn. För skogsägare innebär klimatförändringarna ett behov att öClimate change is expected to affect temperate and boreal forests, potentially causing profound changes to the functioning and the structure of ecosystems. This calls for assessments of the plausible long-term outcomes of a range of climate change scenarios to increase the knowledge base for decision making in forestry. Forest owners need to consider whether current silvicultural management practi

Resource competition between wild pollinators and managed honeybees (Apis mellifera) has the potential to detrimentally impact insect biodiversity as well as wild plant and crop pollination. As honeybees are central place foragers, their competitive impact on wild bees is expected to be structured by hive proximity, in conjunction with foraging decisions related to landscape-level resource availab

Intensification of forest management to increase production of biomass has resulted in considerable habitat degradation with negative impacts on insect biodiversity, including beneficial insect groups such as pollinators. Yet, little is known about how reliant forest understory plants, such as bilberry (Vaccinium myrtillus), are on insect pollinators for reproduction. Here, we quantified the struc

This chapter examines the development of maternal and infant mortality and its connection to changes in medical and healthcare treatment of mothers and infants in the city of Landskrona, Sweden, and its rural hinterland between 1905 and 2015. The authors show that maternal mortality, stillbirth rates, and infant mortality declined strongly in this period. In parallel, hospitals began to admit more

This paper delves into the challenges impeding the seamless integration of artificial intelligence (AI) within the food supply chain (FSC) and introduces a novel methodological framework that combines the NK Model with the Decision-Making Trial and Evaluation Laboratory (DEMATEL) technique. Through an exhaustive literature analysis and expert discussions, the research identifies and categorizes si

Background: The relationship between doing and belonging is rooted in individuals’ engagement in meaningful occupations, which contributes to their sense of connectedness. The meaningfulness of occupation relates closely to the context in which it is performed. However, despite its importance, context is often overlooked and underexplored. Aim: To explore how older adults living in depopulated rur