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Background: Tissue factor is the main initiator of blood coagulation, and tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the initiation of blood coagulation. The genetic variation of TFPI and the relation to venous thromboembolism (VTE), that is, venous thrombosis and pulmonary embolism, remains to be clarified. This exome sequencing study aimed to determine the molecular epide

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the Internationa

RATIONALE: Idiopathic pulmonary fibrosis is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to non-genetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, and exome studies have also been reported to associate with IPF. However, the extent to which rare variants genome-wide may contribut

This review presents how the boreal and the tropical forests affect the atmosphere, its chemical composition, its function, and further how that affects the climate and, in return, the ecosystems through feedback processes. Observations from key tower sites standing out due to their long-term comprehensive observations: The Amazon Tall Tower Observatory in Central Amazonia, the Zotino Tall Tower O

Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric post

Det är sorgligt att Tro och solidaritet sänker sig till denna låga debattnivå av personangrepp istället för att framföra sakligt grundad kritik som skulle kunna föra debatten framåt. Ardins personligt upprörda tonfall blir för mig ytterligare ett bevis på att det är något som skaver och att det finns lik i garderoben. Jag upp­repar mitt förslag om en oberoende utredning av relationen mellan Tro oc

PurposeGermline genetic testing for BRCA1 and BRCA2 variants has been a part of clinical practice for >2 decades. However, no studies have compared the cancer risks associated with missense pathogenic variants (PVs) with those associated with protein truncating (PTC) variants.MethodsWe collected 582 informative pedigrees segregating 1 of 28 missense PVs in BRCA1 and 153 pedigrees segregating 1 of

Background: Adolescence is associated with different feelings and experiences that can negatively affect adolescents’ health and well-being. In the transition between childhood and adulthood, experiences of loneliness are common. A deep form of loneliness is described as existential loneliness. Studies among adults have shown that existential loneliness often arises in connection with transitions

Field-resolved two-dimensional spectroscopy reveals the sub-cycle gain dynamics of a free-running terahertz quantum cascade laser and disentangles resonantly enhanced nonlinearities up to eight-wave mixing in a regime where gain replaces absorption.

Professionaliseringen av diplomatin skedde genom en lång process vars start ofta placeras vid slutet av den Westfaliska freden och 1700-talets slut. Denna professionaliseringsprocess var komplex eftersom den formades av de aktiva diplomaterna, deras livserfarenheter, och av tidsspecifika normer förankrade i ritualer och dokumentation, samt därtill av förändringar kopplade till allt tydligare socia

As the number of antennas scales up, research efforts have been directed towards finding decentralized receiver solutions for multi-antenna architectures. In a recent paper, a novel matrix decomposition - the WAX decomposition - was proposed, which has direct bearing on characterizing the level of decentralization that is possible if the complexity of the decentralized processing is limited. Howev

Solar access describes the amount and distribution of sunlight in living environments. Access to sunlight is crucial for the health and sustainability of cities. It is vital for people and vegetation, and for energy production and conservation. The amount of sunlight entering the city space is restricted by the urban layout, as buildings obstruct solar access by shading each other and the surround