Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138+ plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expression in these cells (P combined = 2.5 × 10-27; β combined = -0.24 SD), but not in peripheral blood or ot

Timetables are important for train punctuality. However, relatively little attention has been paid to the people who plan the timetables: the research has instead been more centred on how to improve timetables through simulation, optimisation, and data analysis techniques. In this study, we present an overview of the state of practice and the state of the art in timetable planning by studying the

A 3D model is developed to investigate solid oxide fuel cells (SOFCs) contacting with optimized interconnect designs and the results indicate that the current density and thermal stress are closely related to both the shape of tip in interconnects and the depth of it in the cathode. The interconnect with triangular rips can yield the best electrochemical performance compared to those with tips of

Automated processes in industry have been implemented in order to get higher production rates, but our knowledge about their effects on physical exposure of the workers is still limited. Muscular load, postures, and movements of the head, neck/shoulders, upper arms, and wrists were recorded in 19 operators from two different car clutch disc production lines (manual and semi-automated). Higher angu

This book explores the need to develop business strategies, organise and fund transformation projects and manage the transformation programme in order to further a circular economy. Circular Business Models outlines sustainable business models that can be used by companies to move transformation forward on a large scale. In addition to business models the book will cover and discuss a number of ot

As a novel coolant, the ethylene glycol-water (50 wt.%:50 wt.%) with graphene nanoplatelets nanofluids (GnP-EGW) were prepared at four weight concentrations (0.01, 0.1 0.5 and 1.0 wt.%), and heat transfer and pressure drop characteristics in a miniature plate heat exchanger (MPHE) were investigated. All nanofluid samples were prepared and diluted by ultrasonic vibration, and their thermal conducti

Consistent datasets of experiments are highly important both for validation and optimization of kinetic mechanisms. An analysis of the data consistency of all available burning velocity measurements of hydrogen flames using the heat flux method at atmospheric pressure is performed in the present work. A comparison of many experiments performed in several laboratories with different types of diluti

We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equin

While slow sand filters (SSFs) have produced drinking water for more than a hundred years, understanding of their associated microbial communities is limited. In this study, bacteria in influent and effluent water from full-scale SSFs were explored using flow cytometry (FCM) with cytometric histogram image comparison (CHIC) analysis; and routine microbial counts for heterotrophs, total coliforms a

A near-unity unselective absorption spectrum is desirable for high-performance photovoltaics. Nanowire (NW) arrays are promising candidates for efficient solar cells due to nanophotonic absorption resonances in the solar spectrum. The absorption spectra, however, display undesired dips between the resonance peaks. To achieve improved unselective broadband absorption, we propose to enclose distribu

Biological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present

Background Peroxisome proliferator-activated receptor-gamma (PPAR 3) exerts anti-inflammatory effects and is therefore a potential target in ulcerative colitis (UC). A novel PPAR 3 agonist (AS002) developed for local action was evaluated ex vivo in biopsies from UC patients and in vivo in mice with low-grade dextran sodium sulfate (DSS)- and trinitrobenzene sulfonic acid (TNBS)-induced colitis. Me

Background: Optimal adjunctive therapy in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI (PPCI) remains a matter of debate. Our aim was to compare the efficacy and safety of bivalirudin to unfractionated heparin (UFH), with or without glycoprotein IIb/IIIa inhibitors (GPI) in a large real-world population, using data from the Swedish national registry, SWEDEHE

National and foreign political identities are discursively constructed, not least through the media. Starting from the contention that Europe serves as the main Other used to define the idea of Russia, this article uses media texts (online and press) to analyse how Russia is constructed as a foreign policy actor in relation to Europe and the ‘West’ more generally. In so doing, the article draws on

Despite the total evacuation time of occupants in a multi-storey building not being affected by pedestrian merging on stairs, the calculation of evacuation times in each individual floor depends on the pedestrian merging ratio. In fact, different merging ratios may cause an evacuation to take place from the top to the bottom or vice versa. A simplified simulation model for the calculation of evacu

Objective: Previous studies have shown that both sleep duration and insomnia have an impact on obesity and central obesity. However, studies of the joint effects of these sleep disorders are still sparse. Methods: The present study utilized data from the Swedish EpiHealth cohort study. Participants (45–78 y) were asked to fill out an internet-based questionnaire. Body mass index (BMI) and central

A scheme has been developed permitting the spatial and temporal characterisation of ultrafast dynamics induced by laser driven proton bursts in transparent dielectrics. Advantage is taken of the high degree of synchronicity between the proton bursts generated during laser-foil target interactions and the probing laser to provide the basis for streaking of the dynamics. Relaxation times of electron

Many animals use vision to detect, discriminate, or recognize important objects such as prey, predators, homes, or mates. These objects may differ in color and brightness-having chromatic and achromatic contrast to the background or to other objects. Visual models are powerful tools to investigate contrast detection, but need to be calibrated by experimental data to provide robust predictions. The

This study comparatively analyzes the calculation performances of different large-eddy simulation (LES) combustion models in a diffused flame simulation to investigate the performances of different LES-turbulent combustion models. The flamelet/progress variable (FPV), partially stirred reactor (PaSR), and transport joint possibility density function (PDF) combustion model are adopted to perform a

Objective To correlate the value of lactate in fetal scalp blood at delivery and the outcomes of the offspring at four years of age. Methods Cases where scalp blood lactate was taken within sixty minutes before delivery were identified from the randomized trial "Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress”. Data were grouped according to the gene