Developmental language disorder (DLD) is a common neurodevelopmental disorder with largely unknown etiology. Rare copy number variants (CNVs) have been implicated in the genetic architecture of other neurodevelopmental disorders (NDDs), which have led to clinical genetic testing recommendations for these disorders; however, the evidence is still lacking for DLD. We analyzed rare and de novo CNVs i

Objectives: To investigate the association between chronic subsyndromal symptoms of depression (SSD), cerebrospinal fluid (CSF) biomarkers, and neuropsychological performance in individuals with mild cognitive impairment (MCI). Methods: Participants included 238 older adults diagnosed with MCI from the Alzheimer's Disease Neuroimaging Initiative repository with cognitive and CSF amyloid beta (Aβ1–

1.Offspring size is a key functional trait that can affect all phases of the life history, from birth to reproduction, and is common to all the Metazoa. Despite its ubiquity, reviews of this trait tend to be taxon‐specific. We explored the causes and consequences of offspring size variation across plants, invertebrates and vertebrates.2.We find that offspring size shows clear latitudinal patterns Offspring size is a key functional trait that can affect all phases of the life history, from birth to reproduction, and is common to all the Metazoa. Despite its ubiquity, reviews of this trait tend to be taxon-specific. We explored the causes and consequences of offspring size variation across plants, invertebrates and vertebrates. We find that offspring size shows clear latitudinal patterns amo

BACKGROUND: Inherited CDKN2A mutation is a strong risk factor for cutaneous melanoma. Moreover, carriers have been found to have poor melanoma-specific survival. In this study, responses to novel immunotherapy agents in CDKN2A mutation carriers with metastatic melanoma were evaluated.METHODS: CDKN2A mutation carriers that have developed metastatic melanoma and undergone immunotherapy treatments we

The Base Erosion and Profit Shifting (BEPS) project of the G20 and the Organisation for Economic Co-operation and Development (OECD) has found a big response in the European Union (EU). Many BEPS measures have been or will be implemented soon in European Union hard law. This paper focusses on the EU-wide legislative implementation of direct tax measures regarding corporate income taxation and tran

The role of exogenous sources of new path development has been underplayed in the literature on regional industrial change so far. The aim of this article is to explore in a conceptual way under which conditions and in what ways non-local knowledge can lead to new path development in different regional innovation systems (RISs). We distinguish between organizationally thick and diversified RISs, t

Abstract: The past two decades have witnessed an ever-growing scholarly interest in regional clusters. The focus of research has mainly been on exploring why clusters exist and what characteristics “functioning” clusters possess. Although the interest in more dynamic views on clusters is not new, in recent years, however, greater attention has been paid to providing better explanations of how clus

Old industrial regions in many cases suffer from a predominance of basic and traditional industries as well as a lack of modern sectors and of innovation. Often we find this type of region oriented to traditional sectors and technology paths. The development of new sectors such as software might help to overcome such problems and contribute to diversification and a better innovation performance of

Innovation is regarded as a highly open and interactive process, where companies absorb, generate and apply knowledge relying both on internal and external sources. They maintain links to various knowledge sources from local to global levels using particular channels for acquiring such knowledge. Although global knowledge networks might render the regional environment less important, we argue that

Regional innovation policies are often applied in a standardized way oriented at best practice models developed elsewhere. These policies fail to take specific sectoral and regional characteristics sufficiently into account. However, innovation processes and problems vary for firms in particular sectors since these exhibit distinct features dependent on their knowledge base. Also, companies are lo

Strengthening of load-bearing masonry walls might often be a solution to extend the life cycle and area of use of existing buildings. In the present work, strengthening of masonry walls by means of externally bonded steel-grid is studied. Full scale clay brick masonry walls were constructed and tested in laboratory under eccentric axial compressive loading. By use of a steel-grid embedded in the rStrengthening of load-bearing masonry walls might often be a solution to extend the life cycle and area of use of existing buildings. In the present work, strengthening of masonry walls by means of externally bonded steel-grid is studied. Full scale clay brick masonry walls were constructed and tested in laboratory under eccentric axial compressive loading. By use of a steel-grid embedded in the r

Pancreatic islet hormone secretion is central in the maintenance of blood glucose homeostasis. During development of hyperglycaemia, the β-cell is under pressure to release more insulin to compensate for increased insulin resistance. Failure of the β-cells to secrete enough insulin results in type 2 diabetes (T2D). MicroRNAs (miRNAs) are short non-coding RNA molecules suitable for rapid regulation

Numerous bioactive biophenol secoiridoids (BPsecos) are found in the fruit, leaves, and oil of olives. These BPsecos play important roles in both the taste of food and human health. The main BPseco bioactive from green olive fruits, leaves, and table olives is oleuropein, while olive oil is rich in oleuropein downstream pathway molecules. The aim of this study was to probe olive BPseco downstream

Introduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Methods: This systematic review summarizes the current literature on the influence of preanalytical variables on CSF biomarker concentration. We evaluated the evidence for three core CSF biomarkers:

Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recrui