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Infection with high-risk human papillomavirus (HPV) has been implicated in the pathogenesis of esophageal squamous cell carcinoma, and up-regulation of telomerase in esophageal adenocarcinoma. We immortalized normal esophageal epithelial cells by over-expression of the HPV16 E6/E7 and human telomerase reverse transcriptase (hTERT) genes. HPV16 E6/E7-induced immortalization was accompanied by reduc

OBJECTIVES: Infectious agents like parvovirus have been implicated as exogenous factors that could trigger onset of systemic lupus erythematosus (SLE). A number of case reports describing a SLE-like presentation of acute human parvovirus B19 infection have been published, but no systematic investigation of the actual seroprevalence in epidemiologically defined SLE populations has previously been r

The HL-60 cell line, derived from a patient with acute promyelocytic leukemia, is a widely used model system to study the cellular and molecular events involved in differentiation of leukemic cells. In a screening for inducers of differentiation of HL-60 cells, cultures of Gliocladium strain 4-93 were found to produce Sch 52900, a previously isolated diketopiperazine (Chu et al,. J. Antibiotics 48

The reaction Ni-58(Ar-36, alpha-qp)88Mo has been studied at 145 MeV beam energy. A detector array consisting of the OSIRIS spectrometer, four charged-particle DELTA-E detectors and seven NE213 neutron detectors has been used to meaure the gamma radiation in gamma-gamma- and particle-gamma-gamma-coincidence mode. The level scheme of 88Mo has been extended up to 11.6 MeV excitation energy and probab

This note gives five applications of the eater-food interaction model (Garding 2005) where cycle length is a function of the eater average birth rate defined as the inverse of average life span. The model extends to an analysis of predator-prey-food cycles (Garding 2000). Here the cycle length is the same as that of en eater-food interaction whose average 'birth rate' is the sum of the average bir

The Stockholm Cancer Prevention Program is to our knowledge the first community intervention program in the world aiming of a reduction in the incidence of cancer. A community diagnosis model has been used in the planning. A thorough description of different organizations in the local communities of Stockholm has been made. A model for describing the organizations or collaborators has been worked

Försöken med förångning från vätskespill av aceton, dietyleter, etanol och metyletylketon och fördelning av brännbara ångor i dragskåp utförda med en inloppshastighet av ca 0.5 m/s visade att: mängden förångad vätska efter spill av olika vätskor vid olika initialtemperaturer kan förutsägas med god noggrannhet med befintliga dataprogram. Vid ett spill stannar den tunga ångan kvar i den nedre delen

1. It has been suggested that the vasoconstrictor response to neuropeptide Y (NPY) is located in the microvessels and that it increases with reduced vessel diameter. The aim of the present study was to analyse quantitatively, on the cat gastrocnemius muscle preparation in vivo, the effects of NPY on total regional vascular resistance (RT) and its distribution to large-bore arterial resistance vess

1. The mechanisms by which cooling inhibits insulin secretion were investigated by capacitance measurements of exocytosis in single mouse pancreatic B-cells maintained in short-term tissue culture. 2. A reduction of the bath temperature from 34 to 24 degrees C produced a gradual inhibition of exocytosis. Inhibition of exocytosis was use dependent rather than time dependent. The steady-state inhibi

Popular Abstract in Swedish I avhandlingen presenteras ett matematiskt ramverk för analys av datagenomströmning i paket-baserade radionät som stör varandra. Tidigare forskning om prestanda i paketradionät täcker många olika system och aspekter. Tidigare publicerade arbeten har dock till stor del varit begränsade till fixa paketlängder. Ramverket som presenteras i avhandlingen tillåter detaljerad aIn this thesis, a probabilistic framework is presented and used for analysis of the throughput of interfering packet-based radio networks, referred to as packet radio networks (PRNs). Previous research on the performance of PRNs covers a wide variety of systems and aspects in varying levels of detail. However, the work presented in the literature has mostly been limited to fixed packet lengths. Th

The dissertation is a case study, the topic of which was a participant-oriented research project in which a development programme for support to parents and care of young people was to be implemented in the organization and the concrete social work was developed and changed through researcher-supported intervention. The project was part of a large-scale effort for change and development carried ou

CASCADE is a full hadron level Monte Carlo event generator for ep, gammap and p (p) over bar processes, which uses the CCFM evolution equation for the initial state cascade in a backward evolution approach supplemented with off-shell matrix elements for die hard scattering. A detailed program description is given, with emphasis on parameters the user wants to change and common block variables whic

Formation of germ tubes by Candida albicans has been assumed as a putative virulence factor. Local anesthetics (LAs), e.g., lidocaine and bupivacaine, are known to inhibit germ tube formation. The study confirmed this observation for the novel drug ropivacaine, although it was less potent than the former two drugs. Hypothesizing that the effect is due to blockading ionic channels, we exposed Candi

This thesis is based on four papers (A-D) treating filtering, smoothing, and maximum likelihood (ML) estimation in general state space models using stochastic particle filters (also referred to as sequential Monte Carlo (SMC) methods). The aim of Paper A is to study the bias of Monte Carlo integration estimates produced by the so-called bootstrap particle filter. A bound on this bias which is inv