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Store-operated Ca2+ influx represents a major route by which cytosolic Ca2+ can be elevated during platelet activation, yet its molecular identity in this cell type remains highly controversial. Using quantitative RT-PCR analysis of candidate receptor-operated cation entry pathways in human platelets, we show a 30-fold higher expression of message for the recently discovered Orai1 store-operated C

A first measurement is reported of the longitudinal proton structure function FL(X, Q(2)) at the ep collider HERA. It is based on inclusive deep inelastic e(+)p scattering cross section measurements with a positron beam energy of 27.5 GeV and proton beam energies of 920, 575 and 460 GeV. Employing the energy dependence of the cross section, FL is measured in a range of squared four-momentum transf

Background: To compare irinotecan with the Nordic 5- fluorouracil (5- FU) and folinic acid (FA) bolus schedule [ irinotecan 180 mg/m(2) on day 1, 5- FU 500 mg/m(2) and FA 60 mg/m(2) on day 1 and 2 (FLIRI)] or the Lv5FU2 schedule [ irinotecan 180 mg/m(2) on day 1, FA 200 mg/m(2), 5- FU bolus 400 mg/m(2) and infused 5- FU 600 mg/m(2) on day 1 and 2 (Lv5FU2- IRI)] due to uncertainties about how to ad

Background: Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas generally have a better prognosis, but little is known on optimal neoadjuvant and adjuvant treatment. New prognostic and treatment predictive biomarkers are needed for improved treatmen

The purpose of this study was to investigate the potential dose reduction to the heart, left anterior descending (LAD) coronary artery and the ipsilateral lung for patients treated with tangential and locoregional radiotherapy for left-sided breast cancer with enhanced inspiration gating (EIG) compared to free breathing (FB) using the AAA algorithm. The radiobiological implication of such dose spa

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Graviditetsdiabetes (GDM) definieras som ett diabetestillstånd som upptäcks under graviditet. Ofta orsakas detta tillstånd av de hormonförändringar som uppträder under graviditet vilka medför en ökad insulinresistens, dvs. ett ökat motstånd mot insulinets effekter. Diagnosen GDM utesluter dock inte diabetes av annan orsak soThe aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited

Rationale and Objectives: To investigate for differences in metabolic concentrations and ratios between patients with systemic lupus erythematosus (SLE) without (group SLE) and those with neurological symptoms (group NPSLE) compared to a healthy control (group HC) in three normal-appearing brain regions: the frontal white matter, right insula (RI), and occipital gray matter and whether changes in

Beta-blockers (bisoprolol, metoprolol succinate, carvedilol, and to some extent nebivolol), given on top of angiotensin-converting enzyme (ACE) inhibitors, improve survival and reduce morbidity in symptomatic stable chronic heart failure (CHF). Early beta-blockade may help to improve survival and especially prevent sudden death, but the usual practice of starting the ACE inhibitor first may lead t

Bo Rothsteins genomgång av svensk välfärdsforskning innehåller några orättvisa betraktelser som inte bör stå oemotsagda. Kommentaren fokuserar på felaktigheter vad gäller asymmestrisk information och tveksamheter vad gäller den svenska pensionsreformen

Objective. New proposed definitions of chronic kidney disease necessitate the development and use of simple and accurate methods for estimating glomerular filtration rate (GFR). Plasma cystatin C has been shown to be a more reliable GFR marker than creatinine and formulae for estimating GFR have been reported. The purpose of this study was to validate a cystatin C-based GFR prediction equation in

Twenty-six names of taxa of Hieracium sections Hieracium, Bifida and Vulgata (Asteraceae) described by the Finnish author J.P. Norrlin based on material from central Sweden and adjacent Norway and originally published in 1888 are lectotypified, and their applications are discussed. The replacement name H. cognatum T. Tyler & Sennikov is proposed as a substitute for the illegitimate H. propinqu

We study the polarization dependence of surface-enhanced Raman scattering (SERS) in coupled gold nanoparticle-nanowire systems. The coupling between the continuous nanowire plasmons and the localized nanoparticle plasmons results in significant field enhancements and SERS enhancements comparable to those found in nanoparticle dimer junctions. The SERS intensity is maximal when the incident light i

Small heat-shock protein chaperones are important players in the protein quality control system of the cell, because they can immediately respond to partially unfolded proteins, thereby protecting the cell from harmful aggregates. The small heat-shock proteins can form large polydisperse oligomers that are exceptionally dynamic, which is implicated in their function of protecting substrate protein

Popular Abstract in Swedish Mellanörats funktion är att överföra och förstärka ljudvågor från luften i hörselgången till innerörats vätska. Denna överföring är optimal när trumhinnan är i neutral position, dvs när trycket i mellanörat och omgivningen är lika. Avvikelser i mellanörats tryck ses vid kroniska mellanöresjukdomar, fr a är det visat ett samband mellan negativt tryck och sjukdomstillstånThe middle ear (ME) pressure is regulated by gas diffusion over the ME mucosa and pressure equalizations via the Eustachian tube (ET). Disturbance in the regulation of ME pressure is believed to contribute to the development of chronic ear diseases. In this work subjects with chronic central perforation (CCP), healthy ears with ventilation tubes (VTs), attic cholesteatoma (AC) and Meniere’s diseas

High-spin states in Tl-198 were studied using the Au-197(alpha, 3n) reaction. The level scheme was considerably extended including two new bands and several non-yrast levels. One of the new bands is possibly a chiral partner to the yrast pi h(9/2) circle times vi(13/2)(-1) band. Two-quasiparticle-plus-triaxial-rotor model calculations suggest an aplanar orientation of the total angular momenta for

Multiexciton absorption cross sections are important for analysis of a number of experiments, including multiple exciton generation and stimulated emisson. We present a rigorous method to determine these cross sections using transient absorption (TA) measurements. We apply the method to CdSe quantum dots (QDs) and core–shell (CdSe)ZnS QDs. The method involves measuring TA dynamics for various exci