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Context Adjuvant imatinib administered for 12 months after surgery has improved recurrence-free survival (RFS) of patients with operable gastrointestinal stromal tumor (GIST) compared with placebo. Objective To investigate the role of imatinib administration duration as adjuvant treatment of patients who have a high estimated risk for GIST recurrence after surgery. Design, Setting, and Patients Pa

It has been suggested that the widespread use of neonicotinoid insecticides threatens bees, but research on this topic has been surrounded by controversy. In order to synthesize which research approaches have been used to examine the effect of neonicotinoids on bees and to identify knowledge gaps, we systematically reviewed research on this subject that was available on the Web of Science and PubM

Local agricultural emissions contribute significantly to the atmospheric reactive nitrogen loads of Danish terrestrial ecosystems. In the vicinity of the sources this may be up to 6-8 kg N ha(-1) yr(-1) depending on location and ecosystem type. This contribution arises from dry deposition of gas phase ammonia derived from local livestock production. Long-range transport, however, often constitutes

The classical pathway of complement is crucial to the immune system, but it also contributes to inflammatory diseases when dys-regulated. Binding of the C1 complex to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activates C1s. C1s cleaves complement component C4 and then C2 to cause full activation of the system. The interaction between C1s and C4 inv

Abstract is not available

Sepsis is a major cause of mortality in intensive care units despite decades of scientific efforts. The lung is recognized as the most sensitive and critical organ affected by the hyper-inflammatory response in septic patients. Immune cell dysfunction develops in later phases of sepsis making patients susceptible to infections. The aim of this dissertation was to reveal pro- and anti-inflammatory

A simple and robust suspended load transport formula for noncohesive sediment is presented for application to river, estuarine, and coastal environments with the use of depth-averaged models. The formula is based on an exponential profile for the concentration and assumes a constant velocity over depth to simplify the calculations. These assumptions were validated with a large data set, including

There is a widespread belief that EU underperforms in the commercialization of publicly funded research and that the appropriate policy response is to transfer the ownership of intellectual property rights to Universities. This paper assesses the validity of these twin beliefs. In addressing the first, we limit ourselves to Sweden which still retains its "Teacher's Exemption" model. In spite of co

We quantified the utilization of terrestrial organic matter (OM) in the food web of a humic lake by analyzing the metabolism and the consumers' stable isotopic (C, H, N) composition in benthic and pelagic habitats. Terrestrial OM inputs (3 g C m(-2) d(-1)) to the lake greatly exceeded autochthonous OM production (3 mg C m(-2) d(-1)) in the lake. Heterotrophic bacterial growth (19 mg C m(-2) d(-1))

We present a growth study and structural characterization of InP-InSb nanowire heterostructures. In contrast to planar epitaxy, this heterostructure can be realized in nanowires without the formation of dislocations, despite an extreme lattice-mismatch (10.4%). We obtain high crystal quality in the InSb nanowires, confirmed by a narrow 111 reflection peak measured by XRD. Additionally, the diamete

Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen s

Coastal low-level jets (CLLJ) are a low-tropospheric wind feature driven by the pressure gradient produced by a sharp contrast between high temperatures over land and lower temperatures over the sea. This contrast between the cold ocean and the warm land in the summer is intensified by the impact of the coastal parallel winds on the ocean generating upwelling currents, sharpening the temperature g

Continuous expression of E6- and E7-oncogenes of high-risk human papillomavirus (HPV) types is necessary for the development and maintenance of the dysplastic phenotype. The aim of the study was to determine the sensitivity and specificity of the APTIMA HPV mRNA assay (Hologic) in predicting future development of high-grade cervical intraepithelial neoplasia (CIN) among high-risk HPV-DNA-positive

The genus Caloplaca in the Nordic countries is currently under revision and this work has resulted in a number of new records for the Nordic countries or provinces within the countries. These records are presented here. Caloplaca arnoldii subsp. arnoldii is reported new to Sweden, C. conciliascens new to Norway and Sweden, C. castellana new to Finland, C. hungarica new to Norway and Sweden, C. isi

The conventional treatment for Dupuytren's disease is surgery. The introduction of alternative treatment strategies creates a need to track outcomes and costs relating to surgical treatment and risk factors, such as smoking and diabetes. This was the aim of the present study.