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In the standard Lambda cold dark matter paradigm, pure dark matter simulations predict dwarf galaxies should inhabit dark matter haloes with a centrally diverging density 'cusp'. This is in conflict with observations that typically favour a constant density 'core'. We investigate this 'cusp-core problem' in 'ultra-faint' dwarf galaxies simulated as part of the 'Engineering Dwarfs at Galaxy formati
Mild cognitive impairment (MCI) can be an early manifestation of Alzheimer's disease (AD) pathology, other pathologic entities [e.g., cerebrovascular disease, Lewy body disease, LATE (limbic-predominant age-related TDP-43 encephalopathy)], or mixed pathologies, with concomitant AD- and non-AD pathology being particularly common, albeit difficult to identify, in living MCI patients. The National In
Most of the work in Referent Grammar so far has focused on syntax, but it is clear that the syntactic rales must rely on some kind of lexical information about the form, meaning and category of the words to be used in the rules. As the lexicon cannot include all possible forms, at least not in such languages as Swedish, Russian and Georgian, some kind of moiphological rules are needed. Such rules
Staphylococcal enterotoxins (SE) pose a great threat to human health due to their ability to bypass antigen presentation and activate large amounts of conventional T cells resulting in a cytokine storm potentially leading to toxic shock syndrome. Unconventional T- and NK cells are also activated by SE but the mechanisms remain poorly understood. In this study, the authors aimed to explore the unde
The goal of this Special Issue is to discuss new challenges in the simulation and management problems of both traditional and innovative BSSs, to ultimately encourage the competitiveness and attractiveness of BSSs and contribute to the further promotion of sustainable mobility. We have selected thirteen papers for publication in this Special Issue. Their contributions are summarized and discussed
Background In Scandinavia, people with a severe mental disorder have a reduced life expectancy of 15-20 years compared with the general public. Smoking is a major contributor, and smoke-free policies are increasingly adopted in psychiatric clinics around the world. We compared potential facilitators and barriers among staff and management, for the implementation of smoke-free psychiatric clinics.
Introduction and abstract Government and Binding theory (Chomsky 1981, Sells 1985) plays a dominant role in current linguistics and is an almost compulsory part of the linguistics curriculum at universities. The advantage of GB is its rigorous theory, allowing only certain simple trees and transformations, supple-mented by certain simple principles and constraints. The GB approach makes it possibl
This study investigates how smallholder differentiation can be reconciled with processes of rural development. Conventional theories and policies are primarily based on assumptions of an undifferentiated smallholder sector. Conversely, some agrarian political economy scholars argue that smallholder differentiation may be correlated with dynamic rural development. To contribute to the debate, rural
Introduction: Predicting the bleeding phenotype is crucial for the management of patients with moderate haemophilia. Global coagulation assays evaluate haemostasis more comprehensively than conventional methods. Aim: To explore global coagulation assays and the bleeding phenotype of patients with moderate haemophilia A (MHA) and B (MHB). Methods: The MoHem study is a cross-sectional, multicentre s
Lignin is one of the main components of plant cell walls, which provides mechanical support for plants and also contributes to resisting against plant pathogenic fungi. In the fruit industry, the lignin content can affect the quality of fruit. The biosynthesis of lignin involves a variety of enzymes, of which caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) is a class of methyltransferases that plays
We prove quantitative, matrix weighted, endpoint estimates for the matrix weighted Hardy-Littlewood maximal operator, Calderon-Zygmund operators, and commutators of CZOs with scalar BMO functions, when the matrix weight is in the class A1 introduced by M. Frazier and S. Roudenko. Even in the scalar case, our estimates are sharper than the results implicit in the literature.
Background: Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter. Aims: To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as SPCs after any cancer. Such two-way analysi
Objectives HPV self-sampling is an option for cervical screening. The aim of this randomised study was to investigate the compliance, prevalence of HPV, and prevalence of severe dysplasia in a vaginal self-sampling group in comparison to cervical samples collected by midwives (control arm). The hypothesis was that there would be no difference between vaginal self-sampling and cervical sampling to
The Supreme Courts in all the Nordic countries reserve, and exercise, the power to set aside unconstitutional laws. In this way, they protect the rule of law and the human rights that are enshrined in their national constitutions. However, they go about this in different ways and treat different constitutional rights in ways distinct from one another. In this chapter, I discuss the development of
Sugarcane processing roughly generates 54 million tonnes sugarcane bagasse (SCB)/year, making SCB an important material for upgrading to value-added molecules. In this study, an integrated scheme was developed for separating xylan, lignin and cellulose, followed by production of xylo-oligosaccharides (XOS) from SCB. Xylan extraction conditions were screened in: (1) single extractions in NaOH (0.25
Marine viral sequence space is immense and presents a promising resource for the discovery of new enzymes interesting for research and biotechnology. However, bottlenecks in the functional annotation of viral genes and soluble heterologous production of proteins hinder access to downstream characterization, subsequently impeding the discovery process. While commonly utilized for the heterologous e
Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacologic
The retrospective investigation was carried out to assess whether subjects who fulfilled our proposed recruitment criteria responded more favorably to anterior cruciate ligament reconstruction (ACLR) than those who did not. We retrospectively analyzed 109 skeletally mature subjects (78 men and 31 women) according to the following proposed criteria of recruitment: (1) pre-injury Tegner activity sco
