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The design of small and high-affinity lectin inhibitors remains a major challenge because the natural ligand binding sites of lectin are often shallow and have polar character. Herein we report that derivatizing galactose with un-natural structural elements that form multiple non-natural lectin-ligand interactions (orthogonal multipolar fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond)
Människans nyfikenhet och strävan att tänja på gränserna för att stilla vetgirigheten är inget nytt och kanske inte ens mest utmärkande för just vår tid. Dokumenterade källor från 1200-talet kan tjäna som goda exempel som stödjer ett sådant antagande. Mary Shelleys roman från början av 1800-talet, Frankenstein, eller moderne Prometeus, är kanske den än idag mest kända kommentaren till detta gränst
The basal ganglia are thought to be particularly sensitive to changes in dopaminergic tone, and the realization that reduced dopaminergic signaling causes pronounced motor dysfunction is the rationale behind dopamine replacement therapy in Parkinson's disease. It has, however, proven difficult to identify which neurophysiological changes that ultimately lead to motor dysfunctions. To clarify this,
Monitoring of ventricular premature beats (VPBs), being abundant in hemodialysis patients, can provide information on cardiovascular instability and electrolyte imbalance. In this paper, we describe a method for VPB detection which explores the signals acquired from the arterial and the venous pressure sensors, located in the extracorporeal blood circuit of a hemodialysis machine. The pressure sig
Lunds universitets tre första kanslerer var också poeter och deras poetiska och kulturella insatser presenteras här, liksom deras insatser för de nyligen (1668) grundade universitetet.The three first chancellors of Lund University are presented as poets and as politicians, ruling and supporting the newly (1668) founded university in Lund.
Kommentar till utgåvan av Hans Granlids radiopjäs "Skaldekonungen Gustafssons kröning"
The Swiss/French writer and political thinker Germaine de Staël (1766–1817) was the daughter of Mme Necker and M. Necker, both of Swiss origin and Protestants. Before the revolution her father had been minister of finance and her mother used to host of one most important salon in Paris. Mme de Staël, as she was called after the marriage in 1786 with the Swedish ambassador to France, Carl-Magnus deThe Swiss/French writer and political thinker Germaine de Staël (1766–1817) was the daughter of Mme and M. Necker. Her father had been Minister of finance before the revolution and her mother used to host of one most important salons in Paris. Mme de Staël, as she was called after the marriage in 1786 with the Swedish ambassador to France, Carl-Magnus de Staël von Holstein, was thus born into one
Nanoparticles affect the immune system as they may interact directly with immune cells and activate them. However, it is possible that nanoparticles also interact with released cytokines and immunologically active enzymes. To test this hypothesis, the activity of myeloperoxidase released from activated neutrophils was measured in the presence of nanoparticles with different chemistry and size. In
The "habitat heterogeneity hypothesis" predicts positive effects of structural complexity on species coexistence. Increasing habitat heterogeneity can change the diversity (number of species, abundances) and the functional roles of communities. The latter, however, is not well understood as species and individuals may respond very differently and dynamically to a changing environment. Here, we exp
Strong sexual dimorphism is commonly observed across species and, e.g., trade-offs between reproduction and maintenance are thought to explain this dimorphism. Here we test how the metabolic and functional phenotypic responses to varying types of environmental stress differ in male and female Drosophila melanogaster (Diptera: Drosophilidae), and how stress impacts the magnitude of sexual dimorphis
En väsentlig drivkraft i företaget att skriva en självbiografi är erfarenheten av skuld - som kan bekännas eller avvisas, och i båda fallen kan denna förbindas med en bestämning av identiteten. Man försvarar sig eller bekänner genom att visa vem man är - detta via berättelsen om ett liv. Mekanismen är vanlig i kristen tradition (Augustinus, Pierre Abélard) och återfinns bl a hos kvinnor, bland ann
A helicopter flying through an atmosphere containing particulates may accumulate high electrostatic charges that can challenge its operational safety. In this paper the influence of the helicopter configuration on its electrification is reported. The current study is based on a recently developed numerical approach in which the turbulent airflow around the rotorcraft is estimated via large-eddy si
Arctic homeotherms counter challenges at high latitudes using a combination of seasonal adjustments in pelage/plumage, fat deposition and intricate thermoregulatory adaptations. However, there are still gaps in our understanding of their thermal responses to cold, particularly in Arctic birds. Here, we have studied the potential use of local heterothermy (i.e. tissue cooling that can contribute to
We explore the phenomenology of a unique three-Higgs-doublet model based on the single CP symmetry of order 4 (CP4) without any accidental symmetries. The CP4 symmetry is imposed on the scalar potential and Yukawa interactions, strongly shaping both sectors of the model and leading to a very characteristic phenomenology. The scalar sector is analyzed in detail, and in the Yukawa sector we list all
Chrome-spinel grains from the fossil ungrouped achondrite Österplana 065 (Öst 065) recovered from Middle Ordovician limestone in Sweden were studied using Raman spectroscopy and TEM. All the studied chrome-spinel grains have a high density of planar fractures and planar features, not seen in chromites from the other L chondritic Ordovician fossil meteorites. Raman spectra of the host chrome-spinel
