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Background: Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in the maintenance of glucose tolerance in healthy humans. Until recently GIP had not been developed as a therapeutic and thus has been overshadowed by the other incretin, glucagon-like peptide 1 (GLP-1), which is the basis for several successful drugs to treat diabetes and
This article explores two works by Swedish artists Emanuel Cederqvist and Henrik Andersson that relate to the vast alpine areas of Norrland in the far north of Sweden. In both works, the artists relate their experiences of the area as it exists today as well as the layers of its history through both archival material and their own photographs. More specifically, both artists use material that show
Organ function depends on the three-dimensional integrity of the extracellular matrix (ECM). The structure resulting from the location and association of ECM components is a central regulator of cell behavior, but a dearth of matrix-specific analysis keeps it unresolved. Here, we deploy a high-resolution, 3D ECM mapping method and design a machine-learning powered pipeline to detect and characteri
The tyrosine residue in amyloid-β (Aβ) is susceptible to attack by various reactive nitrogen intermediates, leading to the formation of 3-nitrotyrosine (3-NT), a post-translational modification associated with the pathophysiology of Alzheimer's disease (AD). Although considered a “dead-end” product, emerging evidence suggests that 3-NT can be reduced to 3-aminotyrosine (3-AT) in vivo. This study a
In 2020, a case report described autologous transplantation of iPSC-derived dopamine (DA) neurons in a Parkinson's disease (PD) patient.1 The team now follows up with the pre-clinical safety and efficacy data of autologous iPSC-derived DA neurons, forming the basis for regulatory approval of a phase 1 clinical trial involving 8 patients.2
In this article I look at two works by Swedish video artist Lina Selander and explore how underlying visual patterns unfold in these works that are connected to certain worldly phenomena. Borrowing from Jacques Derrida, I describe the tendency of being en mal d'archive as an obsession to structure the world into particular recognizable patterns. I argue that Selander's works can be understood as t
During the past decade, scholars have produced a vast amount of research using linked historical individual-level data, shaping and changing our understanding of the past. This linked data revolution has been powered by methodological and computational advances, partly focused on supervised machine-learning methods that rely on training data. The importance of obtaining high-quality training data
Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory half-life can diminish diagnostic efficacy and increase radiation exposure to non-target tissues in the
Fatal accidents in UK’s manufacturing sector are expected to remain the same or increase in coming years. This paper has tried to combat this issue by adapting and further developing a previously defined Safety Framework for the Paint Sector, to evaluate the safety performance of a metal manufacturing facility. To achieve this, the original Safety Framework was updated to align with the current Br
This paper presents the first comprehensive analysis of the systematic archival erasure surrounding the mass killing of Afro-Caribbean laborers at Anna’s Hope during the Fireburn uprising on St. Croix in 1878. Although internal telegrams and eyewitness accounts refer explicitly to a "great slaughter" of Black insurgents at Anna's Hope on 3 October 1878, the incident is conspicuously absent from of
While research on the ramifications of automated decision-making (ADM) for welfare organisations is growing rapidly, less attention has been paid to elucidating the role and experiences of clients in the ADM process. This paper draws attention to how the performance of ADM policy in social assistance organisations working from an activation perspective is not merely a passive way of processing cli
In 1778, a large bronze bell was cast by royal bellfounder Michael Troschell in Copenhagen. Unlike most of his bells, which were destined for church towers, this one was sent to La Grange, the largest plantation on St. Croix in the Danish West Indies. The bell functioned as an instrument of discipline, structuring the workday for more than a thousand enslaved laborers. This paper explores the plan
Can compulsory military service breach human rights protections against slavery, servitude or forced or compulsory labour contrary to Article 8 of the International Covenant on Civil and Political Rights (‘ICCPR’) (and/or equivalent provisions in regional human rights instruments) and, in doing so, meet the threshold of persecution under the 1951 Convention Relating to the Status of Refugees? The
Verksamhetsstatistikens mödor och nyttor har aktualiserats genom kyrkomötesmotionen 2021 om Diakonins kunskap.I denna artikel presenterar Stig Linde lärdomar från andra organisationer, bland annat den finska lutherska kyrkan.
Negative symptoms in schizophrenia spectrum are associated with minimal treatment responses. The search for effective treatments is potentially hampered by heterogenous study-designs and sample characteristics depending on the intervention category. This PRISMA-compliant systematic review/synthesis aims to describe the literature on negative symptoms interventions for schizophrenia spectrum disord
Laser-induced fluorescence has been a staple technique for in-situ probing of radicals and atomic species for decades. The multi-photon equivalent is prevalent in a large variety of applications, where such excitation schemes enable the study of otherwise elusive species and systems. However, these variants inherently suffer from low signal intensities, impeding the broader use of multi-photon ima
Extremely thinned layers and possible folding make the dating of the deepest sections of ice cores especially challenging. Cosmogenic radionuclides have the potential to provide independent age estimates. The 36Cl/10Be ratio is largely independent of production rate changes that affect individual radionuclides and has an effective half-life of 384 kyr, making it an ideal tool for dating the new 1.
