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Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5-15-Year-Old Children Followed in the TEDDY Study

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years.RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young (TEDDY) study, annual assessment of activity using accelerometry was conducted from age 5 years. Time-to-ev

"More" work for nurses : the ironies of eHealth

BACKGROUND: eHealth applications are considered a technological fix that can potentially address some of the grand challenges in healthcare, including burnout among healthcare professionals, the growing burden of patients with chronic conditions, and retaining and recruiting healthcare professionals. However, as the deployment of eHealth applications in healthcare is relatively novel, there is a l

"We Are In-Between". : Health-seeking, Gender and Authority in a Charismatic Church in Mbeya, Tanzania.

This study examines health-seeking, healing practices, gender and authority in a charismatic, locally founded church, the International Church for Healing and Glory (ICHG) in Mbeya, Tanzania. Based on ten months of ethnographic fieldwork carried out in 2013 and 2014, it addresses the situation of people who resort to faith-healing in a medically pluralistic context. The ICHG is a church led by a m

Hydrophysical processes governing brownification : A case study of Lake Bolmen, Sweden

Access to water of good quality and quantity has become more challenging because of a changing climate, as well as an increase in the use of natural resources, which has lead to altered water chemistry. One of these changes is known as brownification, resulting from a higher organic matter content causing a yellow-brown color of surface waters. Brownification has a manifold of side effects for the

Hindu nationalists' strategy of ‘othering’

The article describes how Hindu nationalists are using ‘othering’ and ‘identity signifiers’ to appeal to a broad section of India's fractured population. This, she argues, lies at the root of current religious tensions

Treatment with mycophenolate mofetil is associated with improved nailfold vasculature in systemic sclerosis

OBJECTIVE: To investigate the evolution of nailfold capillary density in patients with systemic sclerosis (SSc) in relation to immunosupressive treatment and autoantibodies.METHODS: Prospective study cohort. Consecutive newly diagnosed SSc patients were included into this study who, in a retrospective review, had at least 2 nailfold capillary microscopy (NCM) measurements performed during the firs

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis

WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6-RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non-haematopoietic cells. However, its physiological function has been

Boron Cage Triggered Micellization of a Neutral–Cationic Block Copolymer and Preparation of Boron-Containing Layer-by-Layer Microparticles

The preparation of a polymer carrier for a boron delivery agent is presented through a combination of experimental and computational studies. A dodecahydro-closo-dodecaborate (B12H12)2– (B12) anion was used as a model boron-containing agent due to its high boron content. Quaternized poly(2-vinyl pyridine)-b-poly(ethylene oxide) (QP2VP-b-PEO) was chosen as a model neutral–cationic block copolymer t

PRAXIS : Critical reflections on violence, justice and peace

Praxis is born out of critical discussions and reflections on violence, justice, and peace, taking place in a classroom at Lund University in a course led by Barbara Magalhães Teixeira and Christie Nicoson (shoutout!). It is the result of frustration linked to the current global state of affairs, as well as the colonial and patriarchal legacies and continued practices within the field we seek a pl

Detection of SARS‑CoV‑2 receptor binding domain using fluorescence probe and DNA flowers enabled by rolling circle amplification

Using rolling circle amplification (RCA) and two different ways of signal readout, we developed analytical methods to detect the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (S protein). We modified streptavidin-coated magnetic beads with an aptamer of RBD through a biotin-tagged complementary DNA strand (biotin-cDNA). Binding of RBD caused the aptamer to dissociate from the biotin-cD

Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa

Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseu

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two

Can Artificial Intelligence Enhance Syncope Management?: A JACC: Advances Multidisciplinary Collaborative Statement : State-of-the-Art Review

Syncope, a form of transient loss of consciousness, remains a complex medical condition for which adverse cardiovascular outcomes, including death, are of major concern but rarely occur. Current risk stratification algorithms have not completely delineated which patients benefit from hospitalization and specific interventions. Patients are often admitted unnecessarily and at high cost. Artificial

The New CERN Low-energy Facilities for Neutrino Detector Tests

The beamlines at CERN's North and East Areas offer secondary beams in a wide range of momenta between 0.5 GeV/c and 400 GeV/c for fixed-target experiments as well as for test beam campaigns with a flexible configuration and variable beam composition and intensities. Recently, two new facilities for neutrino detectors tests have been established in an extension of the CERN North Area in context of

Particle identification in the low-GeV/c regime using Octafluoropropane (R-218) as Cherenkov radiator

Particle identification with threshold Cherenkov detectors, using a moderately pressurized radiating gas with an adequate refractive index, is one of the most common techniques employed in high-energy physics. However, available gases with relatively high refractive indices, that simultaneously preserve their gaseous phase at room temperature and moderate pressures, are rare. Until recently, R-12

Particle production, transport, and identification in the regime of 1-7 GeV/c

The recently constructed H4-VLE beam line, a tertiary extension branch of the existing H4 beam line in the CERN North Area, was commissioned in October 2018. The beam line was designed with the purpose of providing very low energy (VLE) hadrons and positrons to the NP-04 experiment, in the momentum range of 1-7 GeV/c. The production of these low-energy particles is achieved with a mixed hadron (pi

Commissioning Results of the Tertiary Beam Lines for the CERN Neutrino Platform Project

For many decades the CERN North Area facility at the Super Proton Synchrotron (SPS) has delivered secondary beams to various fixed target experiments and test beams. In 2018, two new tertiary extensions of the existing beam lines, designated "H2-VLE" and "H4-VLE", have been constructed and successfully commissioned. These beam lines have been designed to provide charged particles of both polaritie