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The spectrum of adult congenital heart disease in Europe: morbidity and mortality in a 5 year follow-up period - The Euro Heart Survey on adult congenital heart disease

Aims To describe clinical and demographic characteristics at baseline of a European cohort of adults with congenital heart disease (CHD) and to assess mortality and morbidity in a 5 year follow-up period. Methods and results Data collected as part of the Euro Heart Survey on adult CHD was analysed. This entailed information transcribed from the files of 4110 patients diagnosed with one of eight co

Method for identifying ligands activating either excitatory or inhibitory G-protein-coupled receptors by functional coexpression in Xenopus oocytes

Xenopus oocytes devoid of their follicular enclosure provide a frequently used expression system for investigating receptors that transduce through activation of adenylyl cyclase following injection of the appropriate mRNA. However, due to a low basal activity of the cyclase they cannot be utilized to investigate receptor-mediated reductions in endogenous cAMP levels. In order to overcome this lim

Acne vulgaris - A disease of western civilization

Background: In westernized societies, acne vulgaris is a nearly universal skin disease afflicting 79% to 95% of the adolescent population. In men and women older than 25 years, 40% to 54% have some degree of facial acne, and clinical facial acne persists into middle age in 12% of women and 3% of men. Epidemiological evidence suggests that acne incidence rates are considerably lower in nonwesterniz

Impact of the Kuroshio Current on the South China Sea based on a 115 000 year diatom record

We used the tropical oceanic planktonic diatom species Nitzschia marina, Rhizosolenia bergonii and Azpeitia africana/Azpeitia neocrenulata, most commonly found in the surface sediments of the northeastern most South China Sea (SCS) where the Kuroshio Current enters the SCS through the Bashi Strait north of Luzon, to analyse the influence of the the Kuroshio Current on the SCS. The impact of the Ku

Serum levels of procarboxypeptidase B and its activation peptide in patients with acute pancreatitis and non-pancreatic diseases

Background: Carboxypeptidase B from the pancreatic gland may exist in three different molecular and immunoreactive forms: the proenzyme, the active enzyme, and the activation peptide. Aims: To investigate levels of procarboxypeptidase B (proCAPB) and its activation peptide in serum in acute pancreatitis to test the accuracy of these two variables as markers for the diagnosis of acute pancreatitis

The FERRUM project: Branching ratios and atomic transition probabilities of Fe II transitions from the 3d6(a 3F)4p subconfiguration in the visible to VUV spectral region

We report measurements of the relative intensities of 81 emission linesof Fe II between 160 nm and 350 nm (62 168 cm-1 to 28 564cm-1) from 4 levels by high resolution Fourier transformspectrometry, using a Penning discharge lamp as light source. Theserelative intensities have been used to determine the line branchingfractions, which have then been combined with accurate experimentalradiative lifet

High coloration performance of electrochromic devices assembled with electrolytes based on a branched boronate ester polymer and lithium perchlorate salt

An amorphous, colorless, and highly transparent polymer containing boron atoms in its branched chain architecture was synthesised from boron trioxide, poly(ethylene glycol) (PEG) and methoxy end-capped PEG. Electrolytes based on this polymer and different concentrations of lithium perchlorate (LiClO4) were prepared and characterised by impedance spectroscopy, calorimetry and thermogravimetry. The

Defect structure of Ga1-xMnxAs: A cross-sectional scanning tunneling microscopy study

We have studied the atomic scale structure of molecular beam epitaxy grown Ga1-xMnxAs compounds with various Mn concentrations by cross-sectional scanning tunneling microscopy and first principles calculations. Only bright protrusions close to the top layer As atoms are directly correlated with the bulk Mn concentration. Atomically resolved filled and empty states images of this defect are compare

Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes

Sulfonylureas and glinides have similar mechanisms of action but differ in receptor affinity and binding sites and in absorption and elimination rates. This promotes differences in potency, rate of onset, and duration of action. While prominent in single-dose studies, these differences have less importance during long-term sulfonylurea treatment: at ordinary dosages, rapid- and short-acting (glipi

Effect of near-infrared radiation and jet impingement heat transfer on crust formation of bread

Rapid heat transfer methods can be used to speed up the baking, process and create new product properties. This study investigates the effect of air jet impingement and infrared radiation (alone or in combination) on crust formation of par-baked baguettes during post-baking. The parameters investigated are crust color; crust thickness, total water loss, and heating time. The results show that infr