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The aim of this work is practical. We show that the parameters of the widely used operational model of pharmacological agonism are difficult to estimate from single dose-response curves. The parameters can be estimated using pairs of dose-response curves (usually treatment and control) sharing some parameters. Confidence bands for the estimators are developed. In the case of multiple dose-response
Aim. To explore patients' evaluation of a specialized diabetes clinic for management of women with gestational diabetes born in Sweden and the Middle East and its contribution to a decreased level of stress and improved coping capability to promote health in patients receiving care. Background. No studies comparing patients' perceptions of healthcare in women of different origin with gestational
Phosphonic acid (H3PO3) is a candidate as an anchor group that can be used to bind a wide range of molecules to TiO2 surfaces, with practical applications for example in dye-sensitized solar cells. Adsorption geometries and energies of H3PO3 on the TiO2 anatase (1 0 1) surface have therefore been investigated using quantum-chemical periodic hybrid ab initio Hartree Fock density functional theory c
The Black-headed Gull Larus ridibundus is a monomorphic species with little size variation over its wide distribution range. This is in agreement with the wide dispersal of young birds and change of breeding sites of adults between years, which probably means an almost panmictic dispersal of genes. In 1965 I measured and weighed 319 eggs collected at Sjolunda near Malmo, southern Sweden. When I go
Study Design. Observational cohort study. Objective. To evaluate by MRI whether a vertebral fracture during childhood is a risk factor for degeneration of adjacent discs. Summary of Background Data. Several studies infer that trauma is a major cause of disc degeneration. Only 1 study has by magnetic resonance imaging (MRI) evaluated disc degeneration in children with a former thoracic or lumbar ve
Serine protease inhibitors (Serpins) are involved in the pathogenesis of neurodegenerative dementia, including the two most common types, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau
This short essay on how the book is used in Dutch paintings of the 16th and 17th centuries stresses the ambiguities of its overt message and latent symbolism, more varied than mere erudition or inevitable mortality.
Giant cell reparative granuloma (GCRG) is an uncommon lesion most often affecting the jaw but also the small bones of the hands and feet. GCRG overlaps clinically and radiographically with other giant cell-rich tumors such as giant cell tumor of bone (GCTB) and aneurysmal bone cyst (ABC). In the only case of a cytogenetically investigated GCRG reported previously, a balanced translocation involvin
Flertalet nya läkemedel tas fram av universitet och undervisningssjukhus, ofta med betydande offentliga subsidier, för att därefter tas över av läkemedelsindustrin, vars främsta uppgift är att utföra de kliniska prövningarna. Det är viktigt nog, men betydligt mindre innovativt än vad industrin vill få oss att tro, skriver Anders Jeppsson i polemik mot ett tidigare inlägg av Pierre Lafolie.
The difference in length of breast feeding between women with a BRCA 1 mutation and their unaffected relatives was investigated. Fifty women belonging to a family with a known BRCA1 mutation had themselves undergone testing and each had given birth to at least one child. Women with BRCA1 mutation breast-fed their first infant for a significantly shorter period (P = 0.048) and the second and third
Introduction: We investigated whether there were any differences in the frequency and severity of pin site infections by performing pin site care daily or once a week. We studied patients operated on for gonarthrosis by the hemicallotasis technique, using hydroxyapatite-coated pins in the metaphyseal bone and standard pins in the diaphyseal bone. Patients and methods: 50 patients were prospectivel
Spatially and spectrally resolved cathodoluminescence in the scanning electron microscope is a very powerful technique for studying the optical properties of semiconductor structures, especially low-dimensional structures (structures with nanometre-sized features). The technique is generally nondestructive and can be combined with the normal imaging capabilities and analysis possibilities of the s
Objective.. To describe the diversity in dietary patterns existing across centres/regions participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design and setting.. Single 24-hour dietary recall measurements were obtained by means of standardised face-to-face interviews using the EPIC-SOFT software. These have been used to present a graphic multi-dimensional com
