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The present study examined the role of graft placement and behavioural task complexity in determining the functional efficacy of intrastriatal grafts of dopamine-rich fetal ventral mesencephalon (VM) placed in the dopamine (DA) depleted striatum. The functional effects of two different striatal placements of VM grafts were evaluated using tests of drug-induced motor asymmetry, simple sensorimotor
Hippocampal extracellular levels of noradrenaline (NA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were monitored with the microdialysis technique in freely moving rats. In one experiment 30 min samples were collected during 24 h of continuous perfusion, and the monoamine output was compared to the behavioural activity state, as arbitrarily classified in three categories:
Degenerative changes in the forebrain cholinergic nuclei have been studied morphometrically in behaviourally characterized aged female Sprague-Dawley rats. In all regions analysed (medial septum, diagonal band of Broca, nucleus basalis, and striatum) the acetylcholinesterase-positive neurons were reduced in both size and number in the aged (24-months-old) rats as compared to the young (3-months-ol
Human pluripotent stem cells provide new choices for sources of A9-type dopaminergic (DA) neurons in clinical trials of neural transplantation for patients with Parkinson's disease (PD). For example, "self" and HLA-matched A9 DA neurons may improve the patient-to-patient variability observed in previous clinical trials using fetal DA neurons and obviate the need for long-term immunosuppression in
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ICRs in ES cells. KAP1 deletion induces a loss of heterochromatin marks at ICRs, whereas deleting ZFP57 or DN
The Krüppel-associated box (KRAB) domain is a transcriptional repression module responsible for the DNA binding-dependent gene silencing activity of hundreds of vertebrate zinc finger proteins. We previously exploited KRAB-mediated repression within the context of a tet repressor-KRAB fusion protein and of lentiviral vectors to create a method of external gene control. We demonstrated that with th
This thesis is about how and why employees spend large proportions of their working hours on empty labor, i.e. private activities on the job. It is written against the backdrop of a highly debated subject within critical theory, namely the possibility of individuals resisting taken-for-granted power asymmetries. Critical theorists' stress on ideological power and the internalization of submission
This paper summarizes the results and experiences from the full-scale discfilter plant at the Rya WWTP. In 2010 the WWTP was extended with post-denitrification and a discfilter plant for tertiary filtration of the effluent in order to meet the new discharge limits of 10 mg total nitrogen and 0.3 mg/l of total phosphorus. The disc filters receive effluent from both the moving bed biofilm reactor (M
Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recurrent cytogenetic abnormalities, including rearrangements involving the core-binding factor (CBF) transcriptional complex. To better understand the genomic landscape of CBF-AMLs, we analyzed both pediatric (n = 87) and adult (n = 78) samples, including cases with RUNX1-RUNX1T1 (n = 85) or CBFB-MYH11
Direct in vivo gene transfer to the central nervous system (CNS) using recombinant lentiviral vectors (rLV) has emerged as a powerful technique to overexpress various genes of interest in different neuronal populations. This interest is exemplified by the increasing number of studies using rLV vectors to evaluate therapeutic proteins to correct disorders of the nervous system (1–3) or to explore a
For centuries antiquarians and archaeologists have tried to reconcile the terminology of ancient writers on architecture, such as Vitruvius, with the perceived realities of the material record. One particular issue of debate concerns the interpretation of different words for "brick" in Latin. In this paper it is argued that earlier attempts to settle this question are unsatisfactory and leave seve
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by typical motor symptoms that are caused by depletion of dopamine (DA) in the striatum. These symptoms are treated with the DA precursor L-DOPA, or with DA receptor (DAR) agonists. L-DOPA is the most efficacious treatment, but causes complications that limit its utility, in particular, dyskinesia (involuntary movements). Model
Solid oxide electrochemical cells (SOCs) are considered a highly promising technology for providing efficient, sustainable and economic conversion between chemical energy and electrical energy. SOCs can be operated as fuel cells, where electric power is obtained from fossil or non-fossil hydrocarbon fuels depending on the origin or as electrolysis cells, whereby using electrical energy from renewa
A fundamental problem in robotics is the generation of motion for a task. How to translate a task to a set of movements is a non-trivial problem. The complexity of the task, the capabilities of the robot, and the desired performance, affect all aspects of the trajectory; the sequence of movements, the path, and the course of motion as a function of time.This thesis is about trajectory generation a
Humlesugan, Betonica officinalis L., är en av den skandinaviska florans sällsyntaste växter och samtidigt en av de arter som har den längsta dokumenterade historien. Den rapporterades från Stehag väster om Ringsjön i Skåne av Christiern Pedersen redan 1534, Skånes äldsta litteraturuppgift där en växtart knyts till en lokal. I övriga Danmark beskrevs den med lokaluppgift första gången av Peder Laur
