OBJECTIVE: To explore the burden of gout in the Nordic region, with a population around 27 million in 2015 distributed across six countries.METHOD: We used the findings of the 2015 Global Burden of Diseases study to report prevalence and disability associated with gout in the Nordic region.RESULTS: From 1990 to 2015, the number of prevalent gout cases rose by 30% to 252 967 [95% uncertainty interv

Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. Our group has developed a recombinant antibody micr

Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson’s disease. However, the use of fetal tissue is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary

The majority of herbivorous insects are specialized in host use. Even among insects that use many hosts, local specialization is common with a single host plant often being used in any given locality. Here, we establish such a pattern for the European swallowtail butterfly, Papilio machaon. We sampled larvae on five different natural hosts at eight sites in Sweden, each locality showing local mono

The semiarid Punata alluvial fan is located in the central part of Bolivia. The main activity of this region is the extensive agriculture, and groundwater is the main water supply. Local villagers who use groundwater reported that in some places groundwater has a salty taste. In order to investigate the origin of this problem, several TEM soundings were performed in the study area, and they were c

A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer

The design of small and high-affinity lectin inhibitors remains a major challenge because the natural ligand binding sites of lectin are often shallow and have polar character. Herein we report that derivatizing galactose with un-natural structural elements that form multiple non-natural lectin-ligand interactions (orthogonal multipolar fluorine-amide, phenyl-arginine, sulfur-π, and halogen bond)

Människans nyfikenhet och strävan att tänja på gränserna för att stilla vetgirigheten är inget nytt och kanske inte ens mest utmärkande för just vår tid. Dokumenterade källor från 1200-talet kan tjäna som goda exempel som stödjer ett sådant antagande. Mary Shelleys roman från början av 1800-talet, Frankenstein, eller moderne Prometeus, är kanske den än idag mest kända kommentaren till detta gränst

The basal ganglia are thought to be particularly sensitive to changes in dopaminergic tone, and the realization that reduced dopaminergic signaling causes pronounced motor dysfunction is the rationale behind dopamine replacement therapy in Parkinson's disease. It has, however, proven difficult to identify which neurophysiological changes that ultimately lead to motor dysfunctions. To clarify this,

Monitoring of ventricular premature beats (VPBs), being abundant in hemodialysis patients, can provide information on cardiovascular instability and electrolyte imbalance. In this paper, we describe a method for VPB detection which explores the signals acquired from the arterial and the venous pressure sensors, located in the extracorporeal blood circuit of a hemodialysis machine. The pressure sig

Lunds universitets tre första kanslerer var också poeter och deras poetiska och kulturella insatser presenteras här, liksom deras insatser för de nyligen (1668) grundade universitetet.The three first chancellors of Lund University are presented as poets and as politicians, ruling and supporting the newly (1668) founded university in Lund.

Kommentar till utgåvan av Hans Granlids radiopjäs "Skaldekonungen Gustafssons kröning"

The Swiss/French writer and political thinker Germaine de Staël (1766–1817) was the daughter of Mme Necker and M. Necker, both of Swiss origin and Protestants. Before the revolution her father had been minister of finance and her mother used to host of one most important salon in Paris. Mme de Staël, as she was called after the marriage in 1786 with the Swedish ambassador to France, Carl-Magnus deThe Swiss/French writer and political thinker Germaine de Staël (1766–1817) was the daughter of Mme and M. Necker. Her father had been Minister of finance before the revolution and her mother used to host of one most important salons in Paris. Mme de Staël, as she was called after the marriage in 1786 with the Swedish ambassador to France, Carl-Magnus de Staël von Holstein, was thus born into one

Nanoparticles affect the immune system as they may interact directly with immune cells and activate them. However, it is possible that nanoparticles also interact with released cytokines and immunologically active enzymes. To test this hypothesis, the activity of myeloperoxidase released from activated neutrophils was measured in the presence of nanoparticles with different chemistry and size. In

The "habitat heterogeneity hypothesis" predicts positive effects of structural complexity on species coexistence. Increasing habitat heterogeneity can change the diversity (number of species, abundances) and the functional roles of communities. The latter, however, is not well understood as species and individuals may respond very differently and dynamically to a changing environment. Here, we exp