Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might serve as such a marker. Thorough antibody validation was performed for four different HMGCR antibodies. Tumor expression of HMGCR (#AMAb90619, CL

Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N ¼ 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Re

In a 2‐year outpatient treatment programme for alcoholics, 90% of the patients used aversive drugs during some part of the treatment period. Long‐term use was significantly related to a favourable drinking outcome during 2 years subsequent to treatment compared with short‐term use. Long‐term and short‐term users did not differ in background data. Continued use of aversive drugs after the first 6 m

Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer-specific

Abstract— The process of improvement was studied in a 2‐year out‐patient programme for alcoholics. The drop‐out rate was 16%. The analysis was based on recurrent evaluations of treatment contracts including both drinking pattern and psycho‐social treatment objectives. Background data were related to the alcohol adjustment during the first but not during the second year of treatment. Subjects with

Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collabora

Results on the effectiveness of psychosocial treatments for patients with comorbid psychiatric and substance use disorders (dual disorders) will be discussed based on relevant meta-analyses and comprehensive reviews. Findings pertaining to severe (e.g., schizophrenia) and mild to moderate (e.g., anxiety disorders) dual disorders will be presented. The heterogeneity in patient characteristics, trea

Background: The extent of the COVID-19 pandemic and the resulting response has varied globally. The European and African Hepato-Pancreato-Biliary Association (E-AHPBA), the premier representative body for practicing HPB surgeons in Europe and Africa, conducted this survey to assess the impact of COVID-19 on HPB surgery. Methods: An online survey was disseminated to all E-AHPBA members to assess th

Det luriga, lilla ordet "lige" i danska.Der er et lillebitte (pyttelitet) ord i dansk, der giver mange af mine svenske studerende dybe panderynker, når de møder det på mine danskkurser ved Lunds universitet. Flere af dem har egentligt hørt ordet flere gange før, men har ikke helt kunnet knække koden.Ordet er ikke alene drilsk (lurigt), men til tider decideret farligt at have med at gøre, fordi det

In recent years radical right parties have gained electoral strength across Europe,while the vote share of social democratic parties has declined. Using regional data and two fixed effect models this study investigates the impact of manufacturing employment and a range of other economic and demographic variables on the vote share of these parties in both national and European parliament elections

Artikeln undersöker eurons konsekvenser för integration och tillväxt i Östersjöregionen (Polen, Litauen, Lettland, Estland, Finland och Sverige). Efter Sovjetunionens sammanbrott har de baltiska staterna och Polen snabbt hämtat in på Västeuropa. Den globala finanskrisen blev ett kraftigt bakslag för de förra, men i mindre utsträckning för Polen. Penningpolitiken har gjort skillnad: den polska zlotWhich have been the consequences of the euro for integration and economic performance in the Baltic Sea region? After the collapse of the Soviet Union, the three Baltic states and Poland have been rapidly catching-up with Western Europe. The Great Recession becamea great setback for the former, while less so for Poland. A difference is the monetary policy: the Polish zloty depreciated in the criti

Chronic respiratory diseases are among the leading causes of death worldwide, but only symptomatic therapies are available for terminal illness. This in part reflects a lack of biomimetic in vitro models that can imitate the complex environment and physiology of the lung. Here, a copolymeric membrane consisting of poly(ε-)caprolactone and gelatin with tunable properties, resembling the main charac

PURPOSE: To estimate the excess healthcare use and work disability attributable to knee osteoarthritis (OA) in the first five years following diagnosis.METHODS: Among individual aged 40-80 years who resided in Skåne on 31st December 2008, we identified those with a main diagnosis of knee OA during 2009-2014 and no previous diagnosis of any OA from 1998 (n=16,888). We created a comparison cohort ma