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Clinical Trial Update and Novel Therapeutic Approaches for Metastatic Prostate Cancer.

Recurrent prostate cancer (PCa) remains a major clinical challenge. Invasive and metastatic PCa lesions often exhibit a partial and time-limited response to therapy before the cancer progresses and the patient succumbs to the disease. Despite recent advances in early diagnosis and treatment, approximately one-third of treated patients will relapse and become resistant to currently available treatm

Impact of postal and telephone reminders on pick-up rates of unclaimed e-prescriptions.

Objective: To investigate the impact of a reminder (i.e., a mailed letter or short telephone call) from the pharmacy to patients, compared with no reminder in a control group, on the pick-up rates of unclaimed e-prescriptions. Method: Patients, with e-prescriptions transmitted to four large community pharmacies in two counties in northern Sweden and remaining unclaimed after 4 weekdays, were rando

Preoperative assessment of the patient and risk factors for infectious complications and tentative classification of surgical field contamination of urological procedures.

PURPOSE: To assess the patient and identify the risk factors for infectious complications in conjunction with urological procedures and suggest a model for classification of the procedures. METHOD: Review of literature, critical analysis of data and tentative model for reducing infectious complications. RESULTS: Risk factors are bound to the patient and to the procedure itself and are associated w

Association between LTA, TNF and AGER polymorphisms and late diabetic complications.

BACKGROUND: Several candidate genes on the short arm of chromosome 6 including the HLA locus, TNF, LTA and AGER could be associated with late diabetic complications. The aim of our study was therefore to explore whether polymorphisms (TNF -308 G-->A, LTA T60N C-->A and AGER -374 T-->A) in these genes alone or together (as haplotypes) increased the risk for diabetic complications. METHODOLOGY/PRINC

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Medieval Tønsberg, the church and the hinterland: A survey of the ecclesiastical institutions and their property, especially the land that belonged to the church in Medieval Tønsberg.

Kan ny japansk teknik rädda våra stränder

En ny typ av undervattenskonstruktion kallad flexibel vall tar tagits fram och provats med framgång i Japan. Den flexibla vallen består av ett gummimembran som fylls med vatten.

Successful Photopatch Testing with Ketoprofen Using One-Hour Occlusion.

The standard procedure for photopatch testing includes 24-h occlusion of the allergen, followed by irradiation at 5 J/cm2 ultraviolet A (UVA). Due to the timing, a separate visit to the clinic is needed for UV irradiation. The aim of this study was to determine whether a reduction in occlusion time from 24 h to 1 h, in order to simplify the testing procedure, influences test results when photopatc

On the distribution of saline groundwater in the Poopo Basin, central Bolivian Highland

Lake Poopó is a terminal lake of the Bolivian Altiplano, with high salinity and heavy anthropogenic pollution from centuries of extensive mining activity. This study aims to describe how the water quality of groundwater and surface water system in different subwater-sheds of the Lake Poopó varies with geology and hydrology. Measurements of total dissolved solids (TDS) in wells show groundwater bec

Parents' Experiences of Two Different Approaches to Diabetes Care in Children Newly Diagnosed With Type 1 Diabetes.

Various care approaches are provided to support families with newly diagnosed children in their task of diabetes management. We conducted qualitative interviews with 36 parents of 23 children, newly diagnosed with type 1 diabetes. The parents were recruited from participants in a Randomized Controlled Trial (RCT) evaluating hospital-based care (HBC) and hospital-based home care (HBHC), to explore