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Purpose of reviewSmall cell lung cancer (SCLC) is marked by an exceptionally high proliferative rate and poor prognosis. Given its high propensity to metastasize, nearly two-thirds of SCLC patients are diagnosed with extensive-stage (ES) disease when surgery is not a treatment option anymore. Over several decades, only minimal changes have been made in the therapeutic armamentarium of ES-SCLC. Rec
Prostate cancer is the predominant cause of cancer in men, but there is still a lack of biomarkers and treatments for metastatic spread. The initial promise of microRNAs to provide avenues to solve these problems has been dampened by the realisation that microRNAs co-exist in multiple functionally distinct isoforms, for example due to A-to-I editing. We recently found that A-to-I-editing of microR
Målet med detta projekt var att studera hur tre församlingar i tre kyrkliga miljöer – Odarslövskyrka (Torns församling), Ignaberga nya kyrka (Hässleholms församling), och Östra Nöbbelövs kyrka (Simrishamns församling) i Lunds stift – skulle kunna utveckla sina kyrkliga miljöer för egen del och i samverkan för att öka tillgängligheten till de kyrkliga miljöerna och utveckla dem till meningsfulla anThe objective of this project was to study how three congregations/parishes in three church environments – Odarslövs kyrka (Torn’s parish), Ignaberga nya kyrka (Hässleholm’s parish), and Östra Nöbbelövs kyrka (Simrishamn’s parish) in the Diocese of Lund – could develop the church environments under their auspices in order to increase their accessibility and forms of meaningful use for members of t
Sharing travel experience on social media has become an important element of many people’s lifestyle, whether it be as a hobby, personal expression, economic rewards or other purposes. While previous studies have extensively investigated the significant role of social media in the sharing of travel experience and how it influences the travel decisions of others, very little research has examined o
Eldar är en komponerad meditation över språk och våld – det är en fri association kring Marilyn Monroes rollfigur Roslyn i filmen the Misfits. Filmen blev både Monroes och Clark Gables sista film och inspelningen av filmen var besvärlig på flera sätt, inte minst på grund av hettan i Nevadas öken, men också för att Marilyn Monroe drack och använde receptbelagda läkemedel. Det fanns en känsla av att
Under påverkan handlar om hur samhällets utmaningar tar sig in i nära relationer och förändrar människor. Genom personliga berättelser skildras den post-pandemiska tid som skulle bli positiv och social men där istället demokratin och säkerheten är under hot. Samtidigt som samtalen kring samhällsutmaningar kring klimat och migration som fanns före pandemin återigen blivit aktuella i samhällsdebatte
Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs
This paper sets out to investigate what is “conceptual performing arts” and define how one could begin to fill out the lack of a definition. The paper has been peerreviewed within the context of "Högskolepedagogisk utbildning".
Fossevariationer, examensproduktion #1 skådespelarprogrammet 2022Ett utdrag ur fyra pjäser av den norske dramatikern Jon Fosse. "I Fossevariationer låter vi scener ur fyra pjäser bilda en helhet tillsammans med scenografi, kostym och ljus. Rollerna befinner sig på olika platser geografiskt och i livet men ställs inför liknande djupt mänskliga frågor och utmaningar. Eller är det samma personer som
The COVID-19 pandemic illustrated many of the challenges with using science to guide planning and policymaking. One such challenge has to do with how to manage, represent and communicate uncertainties in epidemiological models. This is considerably complicated, we argue, by the fact that the models themselves are often instrumental in structuring the involved uncertainties. In this paper we explor
Trädgårdsgatan is a warm and heartfelt depiction of a divided Helsingborg and Sweden in transition. The play depicts three generations of women and their arduous efforts to deal with every-day life with work, marriage and children in the 1970s, 2000s and 2020s. Almost 50 years separate them, but they are united in their longing for a simpler and better life.At the centre of the story is Birgitta,
Background: Retrospective comparative studies suggest a survival benefit after complete local treatment of recurrence (LTR) in renal cell carcinoma (RCC), which may be largely due to an indication bias. Objective: To determine the role of LTR in a homogeneous population characterised by limited and potentially resectable recurrence. Design, setting, and participants: RECUR is a protocol-based mult
Objectives: To investigate women’s decision-making on induced abortion. Materials and methods: A multi-centre cross-sectional survey among 623 abortion-seeking women in Sweden (2021). The perceived difficulty to decide on abortion was measured using a 7-point Likert scale, and analysed with univariate and multivariate analysis (odds ratios [OR], 95% confidence intervals [CI]). Results: About half
Background: Newborn infants undergoing therapeutic hypothermia (TH) are exposed to multiple painful and stressful procedures. The aim of this systematic review was to assess benefits and harms of pharmacological and non-pharmacological interventions for the management of pain and sedation in newborn infants undergoing TH for hypoxic-ischemic encephalopathy. Methods: We included randomized and obse
Massive Multiple-Input Multiple-Output (MIMO) communication systems are being investigated intensively for positioning services. Enhancing the accuracy on these services in terms of accurate positioning of users is an important goal to improve related applications in the future. Convolutional Neural Networks (CNNs) has been proposed to infer the position of a user from Channel State Information (C
OBJECTIVES: Early diagnosis of critical congenital heart defects (CCHD) improves survival. We evaluated the relative contributions of prenatal ultrasound, neonatal pulse oximetry screening (POS), and neonatal physical examination (NPE) to the early detection (before discharge) of CCHD in the context of increasing prenatal detection, and POS being a national standard since 2013. METHODS: Retrospect
Background: Measuring outcomes facilitates evaluation of palliative services for children, adolescents, and young adults (CAYAs) with life-limiting and/or life-threatening (LL/LT) conditions. Implementation of patient-reported, proxy-reported, or patient-centered outcome measures (hereafter PROMs) is recommended to ensure palliative services. The purpose of this scoping review was to provide an ov
