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The ability of men to remain fertile throughout their lives depends upon establishment of a spermatogonial stem cell (SSC) pool from gonocyte progenitors, and thereafter balancing SSC renewal vs terminal differentiation. Here, we report that precise regulation of the cell cycle is crucial for this balance. Whereas cyclin-dependent kinase 2 (Cdk2) is unnecessary for mouse viability or gametogenesis
I historiens virvlar är en antologi och festskrift tillägnad historikern Eva Helen Ulvros. Ett genomgående tema är biografi som genre. Andra vanliga tema är genus- och kvinnohistoria.
Artikel som sammanfattar Eva Helen Ulvros gärning som historiker, närmare bestämt som forskare, lärare och popularisator.
Med tillitsbaserad styrning och ledning vill vi öka möjligheten för medarbetare att använda sitt professionella omdöme. Detta utrymme påverkas emellertid inte bara av styrningen, utan även av kulturen i organisationen och i sektorn i stort. För att bidra till en god förvaltningskultur bedriver idag de flesta offentliga organisationer ett strukturerat värdegrundsarbete. Många myndigheter väljer att
Artikel om Sven Lidmans roman Thure-Gabriel Silfverstååhl (1910) och den debatt som den väckte samt frågan om nationalism under perioden 1905-18.
Uppföljning är nödvändig i alla verksamheter. Det finns emellertid mycket som tyder på att vi lägger alltför stora resurser på uppföljning och att vi dessutom följer upp på fel sätt. I denna rapport diskuterar jag hur uppföljning kan utformas för att bidra till ökad tillit i allmänhet och ökad tillit till de medborgarnära professionerna i synnerhet, inom ramen för offentliga organisationer. Jag sl
In this roundtable we will present three cases of activist music education, in other words innovative and inclusive practices of music education initiated by courageous institutional leaders and teachers in the Finnish and Swedish context. By activism we mean professional thinking and action that strives toward new ways of making change inside and outside educational institutions through four char
This study addresses gender assignment in six North Scandinavian varieties with a three-gender system: Old Norse, Norwegian (Nynorsk), Old Swedish, Nysvenska, Jamtlandic, and Elfdalian. Focusing on gender variation and change, we investigate the role of various factors in gender change. Using the contemporary Swedish varieties Jamtlandic and Elfdalian as a basis, we compare gender assignment in ot
All languages borrow words from other languages. Some languages are more prone to borrowing, while others borrow less, and different domains of the vocabulary are unequally susceptible to borrowing. Languages typically borrow words when a new concept is introduced, but languages may also borrow a new word for an already existing concept. Linguists describe two causalities for borrowing: need, i.e.
This study uses phylogenetic methods adopted from computational biology in order to reconstruct features of Proto-Indo-European morphosyntax. We estimate the probability of the presence of typological features in Proto-Indo-European on the assumption that these features change according to a stochastic process governed by evolutionary transition rates between them. We compare these probabilities t
This paper employs phylogenetic modeling to reconstruct the alignment system of Indo-European. We use a data set of categorical morphosyntactic features, which take states such as ‘nominative-accusative’, ‘active-stative’, or ‘ergative’. We analyze these characters with a standard Bayesian comparative phylogenetic method, inferring transition rates between character states on the basis of a phylog
Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established preventive approaches beyond hypertension management. Combined genome-wide association study (GWAS) of these two correlated diseases may improve statistical power to detect novel genetic factors for cerebral small vessel disease, elucidating unde
Objectives This study aimed to investigate the importance of potentially inappropriate medications, number of medications and chronic conditions for the risk of hospitalisation among an elderly population. Design This is a case-control study. Setting Population-based study in 2013 of all individuals aged 75 years and older (17 203) in the county of Blekinge in the southeast of Sweden. Participants
The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice.
