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BackgroundAlzheimer’s disease (AD) is the most common cause of dementia and a growing healthcare challenge. Amyloid-targeting therapies (ATT) may slow progression, but implementation is limited by logistical and economic barriers. As primary care is the first contact for most patients with cognitive concerns, quantifying treatment eligibility in this setting is essential. The purpose of this study

BACKGROUND: Although large studies and pooled analyses of individual patient data have demonstrated the safety of deferring coronary revascularization based on a nonischemic intracoronary pressure index result, conflicting findings have emerged in specific patient subsets and with varying follow-up. Thus, we conducted an updated comprehensive systematic review and meta-analysis to investigate the

Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co

Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test-retest experiments have shown high validity and reliability of the positron emission tomography (PET) radioligand [11C]FLB 457 for D2-R quantification in extrastriatal brain regions. However, this radioli

BACKGROUND/OBJECTIVES: Given the risk of a progression, or an undiagnosed endometrial cancer (EC), the treatment of choice is hysterectomy in women with endometrial intraepithelial neoplasia (EIN). The risk of metastatic disease and whether sentinel node (SLN) biopsy should be performed remains unclear. The primary aim of this prospective study was to determine the overall incidence of concurrent

Purpose: To investigate the relationship between heart failure (HF) and chronic kidney disease (CKD) by analysing the prevalence of different stages of CKD and other morbidities in patients admitted with acute heart failure (AHF), as well as readmissions and mortality.Introduction: Chronic kidney disease (CKD) is more prevalent among all phenotypes of HF patients than in the general population. It

The rapid horizontal transmission of antibiotic resistance genes on conjugative plasmids between bacterial host cells is a major cause of the accelerating antibiotic resistance crisis. There are currently no experimental platforms for fast and cost-efficient screening of genetic effects on antibiotic resistance transmission by conjugation, which prevents understanding and targeting conjugation. We

Denna policy brief presenterar policyrelevanta resultat från Women in Power-projektet, vilket undersöker kvinnors professionella nätverkande och kollektivisering inom den svenska energisektorn och hur detta kan bidra till ökad jämställdhet. Projektet är finansierad av Energimyndigheten (2023–2027; P2022-01070). Denna rapport är baserad på två artiklar inom Women in Power-projektet. Genom struktureThis policy brief presents policy-relevant findings from the Women inPower project, which examines women’s professional networking and collective action within the Swedish energy sector and how this can contribute to greater gender equality. The project is funded by the Swedish Energy Agency (2023–2027; P2022-01070). This report is based on two articles from the Women in Power project. Through str

Goal-directed mental processes focused on oneself often co-occur with goal-directed mental processes focused on other people or objects. However, little is known about the mechanisms of this fundamental type of cognitive interaction. The aim of this study was to determine the degree of cognitive interference associated with self-related processing compared with other-related processing. In two sep

Limited and poor delivery of antibiotics is cited as one reason for the difficulty in treating antibiotic-resistant biofilms associated with chronic infections. We investigate the effectiveness of a positively charged, single isomer cyclodextrin derivative, octakis[6-(2-aminoethylthio)-6-deoxy]-γ-CD (γCys) to improve the delivery of antibiotics to biofilms. Using multiphoton laser scanning microsc

OBJECTIVES: This study investigates the expansion of CAR T-cells and its association to treatment outcome.METHODS: Patients with aggressive B-cell lymphomas treated with anti-CD19 CAR T-cell therapy axicabtagene ciloleucel (axi-cel) at Skåne and Sahlgrenska University Hospitals from 2019 to October 2024 were included. CAR T-cells in peripheral blood were measured by flow cytometry. Association bet

Den pågående energiomställningen har inneburit en överhalning av både policy och infrastruktur. Medan beslutsfattare och industrin letar efter nya tillvägagångssätt för att tackla alltmer växande problem som klimatomställningar, resiliens och energifattigdom, är sektorn under total transformation. Det finns en ökad medvetenhet om att energisektorn inte bara består av teknik, utan också av människoDen pågående energiomställningen har inneburit en överhalning av både policy och infrastruktur. Medan beslutsfattare och industrin letar efter nya tillvägagångssätt för att tackla alltmer växande problem som klimatomställningar, resiliens och energifattigdom, är sektorn under total transformation. Det finns en ökad medvetenhet om att energisektorn inte bara består av teknik, utan också av människo

In the New Testament gospel accounts of the empty tomb, there is a strong emphasis on vision and sight. This emphasis is at times understood as a reference to the role of eyewitnesses and their testimonies in the formation of the gospel tradition. This study, however, reads the visual elements of the texts as part of their poetics, as part of their narrative and rhetorical setting.By looking at ei

Jag undersöker den ideala krigar-mannen i två av Gamla testamentets profetböcker: Jesaja och Jeremia. Här beskrivs han som misslyckad och sårbar och i metaforer liknas han till exempel vid en kvinna som föder barn. Under perioden för böckernas tillkomst inträffade en katastrof för folket i Juda, den babyloniska exilen innebar att landet erövrades av stormakten Babylonien och att delar av folket tThis book explores how the prophets Isaiah and Jeremiah depict warriors as vulnerable. In the oracle sections of these prophetic books, vivid imagery shows the warriors failing—not only in their duties as mighty men—but also in living up to the expectations of militarised masculinity. They are presented through imagery of cowardice, weakness, pain, and fear and are often portrayed as women, partic

The conservation community sorely lacks a global indicator of change in insect populations. Given widespread insect declines, addressing this gap is key for conservation and policy targets. We suggest that butterfly monitoring programs can serve as the foundation for an effective global network of insect monitoring. To assess this potential, we bring together an international consortium and calcul

We provide evidence of a positive association between independent directors’ reputation incentives and the magnitude of the CEO pay gap, defined as the difference in compensation between the CEO and lower-ranked executives. The CEO pay gap serves as a proxy for the strength of executive pay tournaments within the firm. Using a sample of S&P 1500 firms, we show that independent directors with s

Accurate and continuous monitoring of inland surface‌ water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia