The skin is our largest organ and its main function is to protect us from uptake of foreign chemicals and from desiccation. The barrier function of the skin is mainly assured by its outermost layer, the stratum corneum (SC). When one wants to deliver a compound into or through the skin, for example in (trans)dermal drug delivery and cosmetics, one generally needs to make the skin more permeable. TThis thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular info

The sky roller ride depends on interaction with the air to create a rolling motion. In this paper, we analyse forces, torque and angular velocities during different parts of the ride, combining a theoretical analysis, with photos, videos as well as with accelerometer and gyroscopic data, that may be collected e.g. with a smartphone. For interpreting the result, it must be taken into account that t

Den globala jordbruksproduktionen har de senaste fem decennierna nästan tredubblats. Produktionsökningen beror på ett allt intensivare jordbruk samt konvertering av naturliga ekosystem till jordbruksmark. Intensifieringen av jordbruket har skett genom ökad användning av högavkastande grödor, mekanisering, bevattning, konstgödsel och bekämpningsmedel. Både intensivare jordbruk och expansionen av joGlobal agricultural production almost tripled within the last five decades. The production increase wasbased on expanding cropland and pastures, as well as the intensification of agriculture, including increased use ofhigh yielding crop varieties, machinery, irrigation, artificial fertilisers, and pesticides. Both, agriculturalintensification and the expansion of agricultural land-use lead to envi

Traumatic brain injury and ischemia can result in marked neuronal degeneration and residual impairment of cerebral function. However, no effective pharmacological treatment directed at tissues of the central nervous system (CNS) for acute intervention has been developed. The detailed pathophysiological cascade leading to -neurodegeneration in these conditions has not been elucidated, but cellular

Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of diseases includes serious or fatal neurological presentations such as Leigh syndrome and there are very limited evidence-based treatment options available. Here we describe that cell membrane-permeable prodrugs of the complex II substrate su

Recent technological developments have challenged the historical methods of composing music for acoustical instruments using traditional scores. However, composers in the Western art music tradition still continue to use them when they explore the realm of sounds in traditional instruments and possible ways to communicate their intentions.The aim of the present study is to describe the development

Importance: The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. Objective: To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) an