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How clinical structures shape diagnostic practices in Swedish hard-to-heal ulcer care : a grounded theory study

Objective The aim of this study was to explore why patients with hard-to-heal ulcers are treated without an aetiological diagnosis, using a grounded theory approach. Design The study employed a qualitative semistructured interview design to gain in-depth insights. Data were collected in 2024, and an explanatory model was formed in accordance with grounded theory analysis. Setting Interviews were c

Avian malaria and the overlooked metabolic pathways underlying mosquito -Plasmodium interactions

Avian malaria parasites pose a significant threat to conservation, affecting populations worldwide. Despite this, our understanding of factors influencing the transmission of avian Plasmodium parasites by vectors is limited to the study of mosquito immune responses. However, the complex life cycle of Plasmodium within the vector suggests that non-immune physiological and metabolic pathways may pla

Genetics and Clinical Findings Associated with Early-Onset Myopia and Retinal Detachment in Saudi Arabia

Autosomal recessive types of both syndromic and non-syndromic inherited myopia are common in Saudi Arabia (SA) because many people marry their relatives. The prevalence of syndromic myopathies in SA, like Stickler syndrome (SS), Knobloch syndrome (KS), and Marfan syndrome (MFS), further complicates the disease spectrum. The causative genes linked to the Knobloch, Marfan, and Pierson syndromes are

Endoscopic papillectomy versus surgical ampullectomy for adenomas and early cancers of the papilla: a retrospective Pancreas2000/European Pancreatic Club analysis

Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA. Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and m

Regional differences in birth prevalence of cleft lip and/or palate in Sweden – a register study of all children born in Sweden between 2000 and 2020

The birth prevalence of cleft lip and/or palate (CL/P) varies globally, and regional differences have previously been observed within Sweden. Updated data on CL/P birth prevalence is needed and has been requested nationally and internationally. This study investigated regional differences and temporal trends in the birth prevalences of CL/P and specific cleft subtypes across Sweden’s six health ca

Bright Near-Infrared-Emitting Organic Nanoparticles Based on Small-Molecule Ionic Isolation Lattices

Near infrared (NIR) fluorescence imaging has received significant attention. However, it remains challenging to develop NIR emitters with a high brightness. Herein, we report a supramolecular approach to formulate NIR fluorescent molecular nanoparticles from cationic NIR fluorophores and cyanostar receptors using their charge-by-charge packing in small-molecule ionic isolation lattices (SMILES). F

Highly expressed odorant receptor orthologs detect the aggregation pheromone lineatin in Trypodendron ambrosia beetles

Chemical communication using pheromones is crucial for the reproductive success of many insect species, including beetles(Coleoptera). Pheromones are detected by specialised odorant receptors (ORs), called pheromone receptors (PRs), in the sensoryneurons of the antennae. The PRs in Coleoptera remain understudied, with only a few receptors being functionally characterised.This limits our understand

Efficient and optimised resource allocation for augmented, virtual and mixed reality applications

Extended Reality (XR) serves as a broad term that encompasses several immersive technologies, including Augmented Reality (AR), Mixed Reality (MR), and Virtual Reality (VR). Currently, most XR devices are connected by cables, which restrict user mobility and negatively impact the overall Quality of Experience (QoE) for users. XR devices face limitations not only in terms of connectivity but also i

Ultra-hypofractionated radiotherapy with focal boost for high-risk localized prostate cancer (HYPO-RT-PC-boost) : in silico evaluation with histological reference

Background and purpose: The study aims to evaluate dosimetric properties of hypofractionated treatment plans integrating focal boost, using registered whole-mount histopathology (WMHP) as reference standard. Methods: Fifteen men from the PAMP trial (EudraCT: 2015-005046-55) were included. Participants had ≥ 1 ISUP Grade group ≥ 4 lesion and underwent [68Ga]prostate-specific membrane antigen (PSMA)

Flexibility of exercise capacity during nestling feeding in blue tits

Nestling feeding in altricial birds is a physiologically demanding phase of the annual cycle. Accordingly, parental effort in breeding songbirds has been suggested to be limited by the maximum capacity to perform sustained aerobic work. However, the maximum capacity for exercise and plasticity thereof is understudied in free-living, breeding songbirds. We tested two predictions related to the plas

The Nurses' Role in the Cardiac Rehabilitation Team : Data from the Perfect-CR Study

Background Nurses constitute a central profession in the cardiac rehabilitation (CR) team delivering comprehensive CR to individuals with cardiovascular disease. We aimed to identify specific components reflecting the nurses' role in the CR team associated with attainment of risk factor targets post myocardial infarction. Methods Center-level data (n = 78) was used from the Perfect-CR study, in wh

Personality Trait Changes After Device-Aided Therapy : Insights From Parkinson’s Patients and Their Close Relatives

Background: It is unclear whether the two device-aided therapies (DATs: deep brain stimulation [DBS] and levodopa–carbidopa intestinal gel [LCIG]) affect personality in patients with Parkinson’s disease (PD). Objective: This retrospective study aims to explore if patients with PD and their close relatives experience any changes in the patient’s personality following the start of DAT. Methods: In t

The Orientation to Life Questionnaire : Sense of Coherence

This chapter describes the core concept sense of coherence (SOC), in terms of definition, measurement, distribution, dimensionality and stability over time. The extensive evidence base of research after Antonovsky died, shows that SOC is a multidimensional and culturally sensitive life orientation. To date, the SOC questionnaire has been used in at least 73 countries all over the world. In additio

Local impact of roughness topography on heat transfer in turbulent flow over rough surfaces

Additive manufacturing (AM), particularly Laser Powder Bed Fusion, produces surfaces with unique, randomly distributed spherical roughness that significantly influences heat transfer and pressure loss. This study models AM roughness using a statistical distribution of spheres and performs high-fidelity simulations at a bulk Reynolds number of 12,000 to evaluate heat transfer on a rough pipe. Stati

Sexual Orientation and Personality Dimensions Measured by the Junior Temperament and Character Inventory among Adolescents

Research on adolescent sexual orientation has expanded in recent decades, yet little is known about its associations with personality traits during this developmental period. This study examined personality dimensions, as measured by the Junior Temperament and Character Inventory, across adolescent sexual orientation groups (asexual, homosexual, heterosexual, bisexual) in a community-based sample

The associations between parenting practices and adolescent alcohol use across mid-and late adolescence : A cohort study from Sweden

Background and aims: The aim of the present study is to examine the association between parenting practices and adolescent alcohol use in a longitudinal sample of adolescents from Sweden. Data and methods: A prospective longitudinal sample of 3,685 adolescents in a nationwide study in Sweden (2017-2019) filled out questionnaires. Baseline data (T1; 2017) was collected from participants at age 15 t

Influence of ethnicity on the diagnostic accuracy of plasma p-tau217 for the identification of Alzheimer's disease : A consecutive mixed memory clinic cohort study

INTRODUCTION: Blood-based biomarkers have demonstrated high accuracy for identifying Alzheimer's disease (AD) pathology. However, the lack of representative cohorts creates a knowledge gap regarding their real-world applicability. We examined the influence of ethnicity on the diagnostic accuracy of plasma tau phosphorylated at threonine 217 (p-tau217) in identifying AD. METHODS: A total of 1170 mi

The impact of common and rare genetic variants on bradyarrhythmia development

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective