Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is as

Enabling vehicles to draw energy from an electric road system (ERS) significantly reduces the need for battery capacity on board the vehicle. It is not necessary, nor realistic, to cover every meter of every stretch of road with ERS. The question then arises how and where the ERS sections should be placed. One way of doing it is to place equally long sections of ERS with a certain separating dista

Purpose: The purpose of this paper is to explore different types of packaging paradoxes and the reasons for their existence in food supply chains. Design/methodology/approach: The research uses a multiple case study approach with rich empirical data from seven leading companies in Swedish food supply chains. The research uses coding and a paradox theory lens to analyse packaging paradoxes, both wi

The increasing levels of software- and data-intensive driving automation call for an evolution of automotive soft-ware testing. As a recommended practice of the Verification and Validation (VV) process of ISO/PAS 21448, a candidate standard for safety of the intended functionality for road vehicles, simulation-based testing has the potential to reduce both risks and costs. There is a growing body

In this paper, we study the problem of error propagation in sliding window decoding (SWD) of spatially coupled LDPC (SC-LDPC) codes. A general decoder model that accounts for error propagation is proposed and analyzed, and the decoded block error rate (BLER) is calculated using the model. In order to improve the BLER performance under decoder error propagation conditions, adaptive variable node (V

The goal of this article is to examine the nature of interaction between the Georgian Orthodox Church (GOC) and the state during the pandemic. The article shows how the church’s gradual acknowledgement of the deadly character of the virus coincided with a strict adherence to certain highly risky religious practices (such as communion from the same spoon), while the Georgian government’s stance in

Miller syndrome is a rare Mendelian disorder caused by mutations in the gene encoding human dihydroorotate dehydrogenase (DHODH). Human DHODH, a Class II DHODH, is an integral protein of the inner mitochondrial membrane (IMM) catalyzing the fourth step of the de novo pyrimidine biosynthesis pathway. Here we present a summary of the state of knowledge regarding Miller syndrome in the absence of any

Human dihydroorotate dehydrogenase (DHODH) catalyzes the fourth step of the de novo pyrimidine biosynthesis pathway and uses ubiquinone Q10, a lipophilic molecule located in the inner mitochondrial membrane (IMM), as its co-substrate. DHODH is anchored to the IMM by a single transmembrane helix located at its N-terminus. Nevertheless, how DHODH function is determined by its surrounding membrane en

Efter många år av arbete med tillgänglighet till produkter, tjänster, program och miljöer förpersoner med funktionsnedsättningar pågår nationellt och internationellt ett skifte i synsättfrån arbete med tillgänglighet för särskilda grupper till inkluderande design som har allamänniskor som målgrupp, så kallad Universell utformning (UU) eller Universal Design (UD)som det heter på engelska. En viktig

de senaste fem åren har begreppet universellutformning fått ett allt större genomslag i den svenskafunktionshinderpolitiken. En viktig anledning till detta är att Sverige ratificerade den så kalladefunktionsrättskonventionen år 2008. I konventionenförs universell utformning fram som huvudprincip ochnationellt åtagande för allt nytt som skapas i samhället.Det innebär att alla nya produkter, varor,

När Certec i år arrangerar ”Certec informerar” för 25:e gången firar vi det genom att i bild och text ge bort en tankebok med 25 viktiga tankar och tankesätt som vuxit fram under åren som gått.Att skapa ny kunskap tar tid. När vi till vardags håller på med att skapa användvärd teknik genom människonära design är det sällan någon quick fix. Bakom uppnådda resultat finns det en ständigt pågående teo

The European Spallation Source (ESS) is a neutron-based research facility under construction in Lund in southern Sweden. The spallation reactions will generate not only the desired neutrons, but also many radioactive byproducts, including 14C. As part of the licensing process, and as recommended by the IAEA, various preoperational studies are being carried out, including mapping the “zero-point” r

Objective: To determine incidence rate and predictors of venous thromboembolic events (VTE) in a population-based cohort with ANCA-associated vasculitis (AAV). Methods: The study comprised 325 patients diagnosed with AAV from 1997 to 2016. All cases of VTE from prior to vasculitis diagnosis to the end of the study period were identified. The BVAS was used to assess disease activity at diagnosis. V

Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly

Objective: To determine the burden of comorbidities in OA and their temporal relationships in the UK. Methods: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 in

Objective: To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, Turkey, Russia, UK and North America. Methods: Patients with a definite diagnosis of AAV who were followed for at least 3 months and had sufficient documentation were included. Data on VTE