Mitochondrial quality control prevents accumulation of intramitochondrial-derived reactive oxygen species (mtROS), thereby protecting cells against DNA damage, genome instability, and programmed cell death. However, underlying mechanisms are incompletely understood, particularly in fungal species. Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function

• Semiarid regions control a large fraction of the interannual variability in the global terrestrial CO2 sink and of atmospheric CO2 growth rate. • Semiarid ecosystems are characterized by recurring disturbances that alter the regional C budgets. As disturbances are expected to become more frequent or intense in the future, quantifying their contribution to semiarid C balance is crucial. • We revi

Background: Contact allergy can manifest in a variety of ways clinically. Systemic contact allergy may occasionally present with pain in muscles and joints. Fibromyalgia is a chronic rheumatic disease characterized by pain and with virtually unknown aetiology. Objectives: The aim of this study was to investigate the contact allergy rates to the sensitizers in a baseline series and compare with cor

We might describe the philosophical issue of human freedom and moral responsibility as an existential metaphysical problem. Problems of this kind are not just a matter of theoretical interest and curiosity: They address issues that we care about and that affect us. They are, more specifically, relevant to the significance and value that we attach to our lives and the way that we lead them. Accordi

Packaging can play a key role in reducing food waste and enabling resource efficient logistics operations. This paper offers insights into why this potential is not fully adopted by companies in food supply chains by exploring adoption barriers for sustainable packaging practices in ten companies in South Africa and Sweden. The paper develops an analytical framework from theory and applies it to t

In this study, the effects of nanosecond plasma discharges on the combustion characteristics of ammonia are investigated over a wide range of mixture properties and plasma settings. The results reveal that the impacts of the plasma on ammonia combustion change non-monotonically by altering the reduced electric field value. Within the studied range of the reduced electric field, i.e., 100–700 Td, i

This Swedish-language investigation concerns the usefulness of the Swedish property tax, introduced in 1862, as a source for studying wealth inequality in the agrarian sector. A one percent sample of all taxpayers in rural areas, following the original taxation lists archived at the National Archives in Stockholm, has been made for four counties in three years: 1870, 1900, 1920. The counties are M

Research in sustainability transitions increasingly acknowledges that the structural characteristics of socio-technical systems differ. However, little attention has been paid to the specific transition dynamics that can result from this structural variation. In response, this paper develops a framework for studying transition dynamics that takes the structural characteristics of socio-technical s

BACKGROUND Anaesthesiology represents a rapidly evolving medical specialty in global healthcare, currently covering advanced peri-operative, pre-hospital and in-hospital critical emergency management (CREM), intensive care medicine (ICM) and pain management. The aim of the European Society of Anaesthesiology and Intensive Care (ESAIC) is to develop and promote a coordinated interdisciplinary and m

This thesis concerns the investigation of direct and inverse resonance results for the Love and the Rayleigh operators, which arise from decoupling the three-dimensional elastic wave equation in the semiclassical limit in the half-space. Direct resonance results in terms of the asymptotic distribution of resonances in the complex plane are obtained for the Love and the Rayleigh operators. An inver

Through interviews, many documents and secondary data, this dissertation investigates how fifty-four women activists participated in the public sphere in Egypt from the outbreak of the 2011 uprising to the re-emergence of the authoritarian regime in 2014. The women activists studied in the dissertation took part in various counter-publics of social movements, opposition political parties, and civi

This article investigates a series of attempts to imbue natural history with humanistic values and align its epistemological goals with those of classical studies in Sweden during the first half of the nineteenth century. By tracing the claims made by a group of twenty-one natural scientists, physicians, and state officials as well as others who took up the cause in response to a government propos

The article traces the circulation of the pedagogical notion of formale Bildung from Germany to Sweden during the first decades of the nineteenth century. At that time, educators and scholars agreed that the goal of secondary education was not to provide practical knowledge, but to train the mind and cultivate moral character. This notion, formulated in full by Friedrich Gedike in the late eightee

This article analyses the creation of a new template for pedagogical scholars during the early decades of the nineteenth century in Sweden, encased in the tragic persona of Carl Ulric Broocman. Broocman, one of the most influential pedagogical scholars of his time, died at the peak of his career and was posthumously cast as a perfect teacher and scholar in his obituary. On closer inspection, the o

Finansieringen av nationella vetenskapliga tidskrifter har blivit ett lömskt problem eller ett wicked problem inte bara för historia utan för humaniora i stort. Liksom andra lömska problem utmärks denna fråga av att själva problembeskrivningen är föränderlig, definitionerna undflyende samt att problemet är sammanvävt med andra komplexa problemområden. För en långsiktig lösning är det därför nödvänThe question of how to fund Swedish academic journals such as Scandia has become a wicked problem, not only for history but also for the humanities as a whole. This issue is confounded by the difficulty in terms of categorizing these journals and their funding needs and further complicated by the global movement towards open access. For the humanities, the issue of how to fund these journals is of

TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In patch-clamp bilayer recordings, ∆1-688 hTRPA1, without the N-terminal ankyrin repeat domain (N-ARD), wa

AIMS: Proneurotensin (Pro-NT) is a strong predictor of cardiometabolic disease including type 2 diabetes and obesity, however, the effect of lifestyle change on Pro-NT has not been investigated in this context. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised con

Middle Eastern immigrants constitute a growing proportion of the European population and compared to native Swedes are more insulin resistant, which can contribute to atherosclerosis. Quantitative first pass perfusion (qFPP) using cardiovascular magnetic resonance (CMR) can detect early signs of cardiovascular disease (CVD). The aim was to study if myocardial perfusion differs between healthy male

Background: The diagnosis of paediatric cancer is a crisis for the parents who are the primary caregivers of the affected child. A comprehensive assessment of the longitudinal impact of childhood cancer on parental mental health and the potential sex differences between the parents is lacking. Thus, we aimed to explore the subsequent short- and long-term mental health outcomes among the parents of

Background: Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based evidence is still lacking. Methods: By accessing a couple of nationwide Swedish registers, we performed a cohort study to explore whether using proguan