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This study analyses the perceived key interests, importance, influences and participation of different actors in harmonizing the processes and mechanisms of a distributed research infrastructure. It investigates the EU-funded initiative, BioBanking and Molecular Resource Infrastructure in Sweden (BBMRI.se), which seeks to harmonize the biobanking standards. The study interviews multiple actors inv
Nobel Laureates in Physiology or Medicine who received the Prize between 1969 and 2011 are compared to a matched group of scientists to examine productivity, impact, coauthorship and international collaboration patterns embedded within research networks. After matching for research domain, h-index, and year of first of publication, we compare bibliometric statistics and network measures. We find t
Research infrastructures such as biobanks are increasingly important for science and society. This paper focuses on the transition of biobanks from being a research tool of individual research groups to complex, internationally networked research infrastructures supporting large-scale biomedical investigations, and the challenges that this change poses for governance in relation to management, fun
Patent citations added by examiners are often used as indicators of technological impact and knowledge flows, despite various criticisms. In this study we analyze the distribution of examiner patent citations according to patent characteristics in order to show their limitations. According to our findings, the number of applicant citations included is dependent on the science-base of the technolog
For scientists and policy-makers it is important to understand the value of networks and collaborations for scientific quality and commercialisation of research results. The interplay between funding mechanisms and research collaborations is of particular importance in this context. We explore this interplay with an empirical analysis of international research collaborations involving EU countries
Bibliometric indicators are increasingly used to fund and evaluate scientific research. Since the number of authors in a paper and the number of has increased it is difficult to determine the individual contribution of authors. Suggested approaches include the study of author position or the corresponding author. Our findings show that the corresponding author is most likely to appear first and th
Most studies of patents citations focus on national or international contexts, especially contexts of high absorptive capacity, and employ examiner citations. We argue that results can vary if we take the region as the context of analysis, especially if it is a region with low absorptive capacity, and if we study applicant citations and examiner-inserted citations separately. Using a sample from t
The increase of co-authored papers is a recognized fact. At the same time the factors influencing this change is not well known. This article aims at studying the patterns of EU science co-authorships. We analyzed articles published in 18 EU countries and their intra-EU (within EU) and extra-EU (with partners outside EU) co-publication pattern in five scientific fields. The results point to a Euro
The purpose of the study was to identify the bactericidal mechanism of action and time kill assay of a medicinal plant Sphaeranthus indicus Linn against some highly resistant Gram positive and Gram negative clinical pathogens. Antimicrobial action of this plant was compared with four different antibiotics using disk diffusion method. The MIC and MBC of extract was measured by broth dilution method
Background: Gastric ulcers are painful sores with discontinuity in the entire thickness of stomach lining. Proton pump inhibitors (PPIs) are among the major classes of drugs used in treatment of gastric ulcers by inhibiting H+/K+ATPase pump thus reducing acid secretion. The prototype of PPIs is omeprazole, one of its new derivatives, esomeprazole is known to have superior activity against NSAIDs i
Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophul
L-3,4-dihydroxyphenylalanine (L-DOPA) isa classical example of an amino acid that isan immediate precursor to dopamine andhas been developed as an effective therapeuticagent for a neurodegenerative disease.Dopamine deficiency is known to be acore pathogenic event in Parkinson's disease(PD). It is the main neurotransmitter responsiblefor modulation of motor behaviour.Peripherally given, L-DOPA is t
The presence of focal EEG abnormalities in juvenile absence syndrome (JAS) may cause it to be misdiagnosed as focal epilepsy. The purpose of our study was to determine the presence of focal EEG abnormalities in patients with JAS and to ascertain whether some clinical features or antiepileptic drugs (AEDs) have an effect on focality. Serial EEGs of 52 consecutive patients with JAS were retrospectiv
The objective of the present study was to investigate the effect of polymorphism on in vitro-in vivo properties of carbamazepine (CBZ). For this purpose, three different polymorphs and a dihydrate of CBZ were obtained and the conventional tablets of these crystalline forms at the dose of 200 mg were prepared. The polymorphs were examined by the IR and DSC analysis. The tablets were investigated by
Purpose - This article attempts to match the future needs of older people with the possibilities arising from applications based on new technology. Design/methodology/approach - This article examines the implications of novel applications for active ageing policy. These applications are forecast to arise from the convergence of two or more previously separated science disciplines and technologies,
