Sökresultat

The Tvären structure in southeastern Sweden has been listed as a confirmed marine-target impact structure for decades. However, to date, no measurements and/or indexed data of planar deformation features in quartz grains from the structure have been published or any other unequivocal evidence of impact. Here, we present an investigation aimed at searching for shocked quartz in the 224 m deep Tväre

In 2022, the Intergovernmental Panel on Climate Change (IPCC) established that global greenhouse gas emissions trajectories are not on track to limiting warming to less than 2 ° C above pre-industrial averages (IPCC 2022a). Given that broader progress towards ambitious climate change and sustainability goals remains incremental, a whole-of-society approach, including transformative innovation in t

Acute postoperative pain remains a major clinical challenge, affecting both recovery and resource utilisation. Beyond nociceptive input, pain is shaped by cognitive and emotional factors, including patient expectations. This narrative review examines the role of expectations in perioperative pain modulation, framed within predictive coding and Bayesian inference models. These models conceptualise

The use of X-ray structures to determine and interpret the ferryl iron-oxygen bond order in molecular oxygen-activating heme enzymes has, in the past, been controversial. This has mainly stemmed from the susceptibility of ferryl species to X-ray-induced electronic state changes. In this work we establishe using time-resolved serial femtosecond X-ray crystallography (tr-SFX) on a dye-decolourising

Epoxide hydrolases are essential enzymes that convert epoxides into 1,2-diols, contributing to detoxification, metabolism, and signaling in a wide range of organisms. In this study, we employed hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to investigate the catalytic mechanism of potato epoxide hydrolase 1 (StEH1), specifically focusing on the hydrolysis of trans-stilbene oxid

Quantum refinement (QR) is an approach in which the empirical restraints used in standard structural refinement to ensure that the details of the structure, e.g. bond lengths and angles, make chemical sense are replaced by more accurate quantum mechanical calculations for a small but interesting part of the structure. QR has previously been used for X-ray and neutron crystallography, cryogenic

Herein, we present a case of severe immune-related adverse events (irAEs), myocarditis with myositis, and myasthenia gravis overlap syndrome (IM3OS) in a patient receiving an immune checkpoint inhibitor (ICI), as adjuvant therapy after surgery for muscle-invasive bladder cancer. An 80-year-old woman who had undergone a total cystectomy for bladder cancer presented with ptosis, diplopia, and paraly

Aluminum is a promising carbon-free energy carrier, but advancing its use requires detailed understanding of its combustion behavior at the single-particle level. Measuring the transient surface temperatures of burning aluminum droplets is particularly challenging due to their small size, extreme temperatures, and fast dynamics. In this work, we demonstrate a multispectral pyrometry approach based

High-brightness electron bunches drive fundamental research in particle physics and photon science. Key to achieving a high brightness is to have a low transverse emittance, which ensures that the bunch can be tightly focussed. In radiofrequency accelerators a low initial emittance can be rapidly degraded due to space charge forces, which are greatly diminished once the electron bunch attains a re

Radio-frequency particle accelerators are engines of discovery, powering high-energy physics and photon science, but are also large and expensive due to their limited accelerating fields. Plasma-wakefield accelerators (PWFAs) provide orders-of-magnitude stronger fields in the charge-density wave behind a particle bunch travelling in a plasma, promising particle accelerators of greatly reduced size

For plasma-wakefield accelerators to fulfill their potential for cost effectiveness, it is essential that their energy-transfer efficiency be maximized. A key aspect of this efficiency is the near-complete transfer of energy, or depletion, from the driver electrons to the plasma wake. Achieving full depletion is limited by the process of re-acceleration, which occurs when the driver electrons dece

Detailed knowledge of particle-beam properties is of great importance to understand and push the performance of existing and next-generation particle accelerators. We recently proposed a phase-space tomography method to reconstruct the five-dimensional (5D) phase space, i.e., the charge density distribution in all three spatial directions and the two transverse momenta. Here, we present the first

FLASHForward is an experimental facility at DESY dedicated to beam-driven plasma-accelerator research. The X-2 experiment aims to demonstrate acceleration with simultaneous beam-quality preservation and high energy efficiency in a compact plasma stage. We report on the completed commissioning, first experimental results, ongoing research topics, as well as plans for future upgrades.