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Introduction: The BIN1 rs744373 single nucleotide polymorphism (SNP) is a key genetic risk locus for Alzheimer's disease (AD) associated with tau pathology. Because tau typically accumulates in response to amyloid beta (Aβ), we tested whether BIN1 rs744373 accelerates Aβ-related tau accumulation. Methods: We included two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI], n = 153; Biomark

As an emerging country, Vietnam needs competent business entrepreneurs who are expected to modernize the economy, renew business and management practices, and develop sustainable growth strategies. The mission of business and management education, thus, is to prepare graduate students for the development of transitional Vietnam and future global challenges. Graduates’ competency, according to comp

Patients undergoing surgical aortic valve replacement (SAVR) are at high risk for atrial fibrillation (AF) and stroke after surgery. There is an unmet clinical need to improve stroke prevention in this patient population. The LAA-CLOSURE trial aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patie

This article focuses on bodily care as the basis of economy. Drawing on Luther and Scandinavian Creation Theology, with an emphasis on shared situatedness and society, I discuss contemporary threats to welfare states. Conservative arguments in favor of family and small communities, combined with charity, provide a cultural/religious alibi for a global “neoliberalism,” where citizens are replaced b

Despite recent technological advancements allowing the characterization of cancers at a molecular level along with biomarkers for cancer diagnosis, the management of ovarian cancers (OC) remains challenging. Proteins assume functions encoded by the genome and the complete set of proteins, termed the proteome, reflects the health state. Comprehending the circulatory proteomic profiles for OC subtyp

The analysis of the verb phrase poses interesting problems. This paper suggests a binary solution where the auxiliary is treated as one constituent and the main verb complex as another. Auxiliaries are thus not treated as main verbs as was suggested by Ross 1967 (and followed in the first version of Referent Grammar, Sigurd 1987). The auxiliary may be lacking (latent, empty), in which case the mai

Commensality (the act of eating together) is studied in a range of disciplines and often considered important for social communion, order, health and well-being, while simultaneously being understood as in decline (especially the family meal). However, such claims are also contested in various ways. In this paper, we discuss the expanding field of commensality research and critically reflect on th

This chapter provides an overview of some historical struggles against domination that are based in ‘radical religious’ communities. Yet what qualifies as ‘religious’ and ‘radical’ is very open to interpretation, and typical interpretations of ‘religion’ in particular often betray a colonial mindset which this chapter seeks to problematise. By presenting a deliberately broad range of examples and

Risk assessments are often performed at multiple system levels in order to inform decision-making; for example, on multiple levels within an organization or on multiple societal levels. One way to conduct risk assessments on the higher system levels is to utilize and aggregate risk information from the lower level assessments. However, the process of aggregating risk information can be highly comp

Critical infrastructure such as transportation, power, telecommunication and water supply systems accommodate and enable flows of essential goods and services that modem societies are highly dependent upon. These critical flows connect countries, organizations and communities, and are imperative for upholding vital societal functions. Disruptions of such flows hold the potential of severe and pote

The sources, extent and margins of parental obligations in taking decisions regarding their children’s medical care are subjects of ongoing debates. Balancing children’s immediate welfare with keeping their future open is a delicate task. In this paper, we briefly present two examples of situations in which parents may be confronted with the choice of whether to authorise or demand non-therapeutic

Many risks addressed in land use planning, such as flooding and accidents involving hazardous materials, have widely different characteristics which makes them difficult to compare. Yet, these risks sometimes need to be considered together in order to support decision-making. Furthermore, risks can sometimes affect each other, which differentiate the land use planning context from situations where

The various problems associated with co-authorship of research articles have attracted much attention in recent years. We believe that this (hopefully) growing awareness is a very welcome development. However, we will argue that the particular and increasing importance of authorship and the harmful implications of current practices of research authorship for junior researchers have not been emphas

In this paper we look at the implications of a prospective emerging technology for the case in favor of, or against, postmenopausal motherhood. Technologies such as in vitro derived gametes (sperm and eggs derived from non-reproductive cells) have the potential to influence the ways in which reproductive medicine is practiced, and will bring new dimensions to debates in this area. We explain what

In this paper we will look at the various ways in which infertility can be understood and at how need for reproductive therapies can be construed. We will do this against the background of research with artificial gametes (AGs). Having explored these questions we will attempt to establish the degree to which technologies such as AGs could expand the array of choices that people have to reproduce a