A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren's disease
OBJECTIVES: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.METHODS: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were avail