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Today, the vast majority of more than half a million cuneiform inscriptions unearthed across the Middle East are housed in museums and collections in Europe and North America. Their study and publication is confined to books, journals, and electronic resources rendered in English, French, German, Italian, and Spanish. Even the rapidly growing ecosystem of online catalogues and research platforms d
Background: Persistent circulating cell-free tumor DNA (ctDNA) detection during neoadjuvant treatment of early-breast cancer (EBC) indicates high-risk disease. Detection of ctDNA post-resection of EBC (molecular residual disease, MRD) indicates occult metastatic disease and impending disease relapse. For ctDNA to be integrated into EBC management, accessible and scalable diagnostic tools are requi
Denna avhandling undersöker antropocentriska frihetsbegrepp och utvecklar en förståelse av interspecies frihet som ett relationellt tillstånd som möjliggör för människor och andra djur att leva ihop utan dominans. Frihet har traditionellt uppfattats som ett uteslutande mänskligt begrepp, grundat i hierarkiska strukturer som legitimerar förtrycket av andra djur. Med utgångspunkt i kritiska djurstudThis dissertation interrogates anthropocentric conceptions of freedom and develops an account of interspecies freedom as a relational condition enabling humans and other animals to flourish without domination. Freedom is traditionally conceived as an exclusively human concept, grounded in hierarchical structures that legitimise the oppression of other animals. Drawing on critical animal studies, e
High-power proton linacs are envisaged as drivers for numerous applications, such as neutron spallation sources for condensed matter study, neutrino factories, muon colliders, hybrid systems for transmutation or energy production, production of rare isotope beams for nuclear physics studies, etc. These linear accelerators are intended to deliver proton beams of up to several MW and tens of MW powe
Scientific breakthroughs in the field of cell and gene therapy lay the groundwork for therapeutic innovation, but their translation and integration into routine care is delayed by systemic inefficiencies and limited cross-sector alignment. The Advanced Therapies model of Lund is a proactive and integrated approach designed to accelerate the development of advanced therapies from discovery to reimb
Introduction: Vitamin D deficiency has previously been shown to be associated with cancer-related fatigue. If vitamin D deficiency affects fatigue in frail elderly has not been studied before. The aim of this study was to investigate associations between vitamin D, fatigue, frailty, and sarcopenia in frail elderly with cancer (FEC) and without cancer (FE) in comparison with healthy controls. Metho
The experimental realization of quantum molecular spectroscopy with entangled photons remains challenging owing to the low signal-to-noise ratio resulting from the use of low-flux entangled photons. High-flux entangled photons via intense entangled beams can be used to improve the signal-to-noise ratio, but the presence of unentangled photons contaminates the quantum signal stemming from entangled
This paper explores regenerative building production as an approach that goes beyond minimising environmental harm to actively generating net-positive socio-ecological impacts. Grounding the discussion in sustainability transitions theory, we highlight how construction significantly contributes to global carbon emissions and waste. Using the phenomena construction methodology, a conceptual framewo
Susceptibility testing of clinical multidrug-resistant (MDR) and reference P. aeruginosa strains was performed using the standard twofold serial dilution method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antiseptics were determined. MIC and MBC values were also interpreted as the bacteriostatic index of antiseptic activity (BSIAA) and the bactericid
Den här boken ger en introduktion till straffrättens påföljdssystem. Framställningen omfattar både det regelverk som gäller och de sammanhang som påverkar påföljdsbestämningen: straffprocessen, de principer och värden som bär upp systemet, frågor om straffets funktion och rättfärdigande samt den historiska utvecklingen av påföljdssystemet. Förutom att presentera påföljdsbestämningens övergripande
Directed movement is fundamental to animal behavior, yet the mechanisms underlying robust orientation remainincompletely understood. The ball-rolling dung beetle offers a unique model system for investigating these mechanismsdue to its distinctive navigational challenges: maintaining a straight-line trajectory while moving backwardand transporting a dung ball. In this thesis, I investigates orient
Introduction Parkinson’s disease (PD) is a common neurodegenerative disease, which has extensive pathology that critically includes the loss of midbrain dopaminergic neurons. This loss leads to debilitating motor features such as bradykinesia and rigidity, as well as some non-motor symptoms. Intracerebral dopamine cell transplants have been explored for many years as a new approach to treating PD
Importance Women with adverse pregnancy outcomes have higher subsequent cardiovascular risks, but their long-term risk of atrial fibrillation (AF) and potential causality are unclear. A better understanding of such risks is needed to identify women with high risk early in life and guide interventions to prevent AF and its complications. Objective To determine long-term risks of AF associated with
A water-based sol–gel strategy driven by boron coordination enables the direct fabrication of transparent, photoactive TiO2 films under ambient conditions. Mixing ammonium oxo-lactato titanate with boric acid produces non-fluidic gels that dry into amorphous TiO2 films containing rutile-like domains.
Oligodendrocyte precursor cells (OPCs) display functional plasticity beyond myelination. Kuwata et al. explore how hypoxia shapes OPC features after ischemic stroke. Combining single-cell transcriptomics with in vivo and ex vivo models, they reveal oxygen-dependent OPC phenotypes promoting angiogenesis and remyelination, highlighting OPC versatility and potential for novel stroke cell therapies.
We propose a new class of high-rate spatially coupled LDPC (SC-LDPC) codes based on the convolutional selforthogonal codes (CSOCs) first introduced by Massey. The SCLDPC codes are constructed by treating the irregular graph corresponding to the parity-check matrix of a systematic rate R=(n-1) / n CSOC as a convolutional protograph. The protograph can then be lifted using permutation matrices to ge
Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st
Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for
