Over recent decades, management of people with hemophilia (PwH) has been greatly improved by scientific advances that have resulted in a rich and varied therapeutic landscape. Nevertheless, treatment limitations continue to drive innovation, and emerging options have the potential to realize further improvement. We advocate four general principles to optimize benefits from innovation: individualiz

Objective: The concept of proportionate and disproportionate functional mitral regurgitation suggests that transcatheter edge-to-edge mitral repair may benefit patients with a smaller left ventricle relative to a higher regurgitant burden. The clinical relevance of proportionality remains unknown in mitral operations for ischemic mitral regurgitation. We aimed to characterize the association betwe

This paper aims to provide an overview of the impact of the COVID-19 pandemic on control engineering education worldwide. The authors, who are educators in the control education field from various countries across all continents, first summarize their experiences to present a global perspective on the different solutions adopted in control education during the pandemic. Afterwards, collected infor

Background: Chronic lymphocytic leukemia (CLL) is a common hematological malignancy with highly variable clinical presentation. Many patients never require any treatment but for the others, chemotherapy, immunochemotherapy, and newer targeted therapies have changed the treatment landscape. Diagnostic age influences the applied treatment, and we thus wanted to analyze age-specific survival trends t

Background: Periampullary diverticulum (PAD) is commonly encountered in endoscopic retrograde cholangiopancreatography (ERCP) procedures. Objectives: We sought to determine whether PADs are associated with a lower success rate of cannulation and an increased risk of adverse events. Design: A retrospective cohort study was conducted using prospectively gathered nationwide registry data. Methods: Us

Background: The Occupational Balance Questionnaire (OBQ11) is a commonly used instrument for measuring self-rated occupational balance. It needs further development, and therefore an additional 11 tentative items have been developed. One aspect of this is studying the interpretations and reasoning of people responding to the items/instrument. Aim: The aim of this study was to explore and describe

The market for home deliveries of food and groceries has been growing in the last years, and with it so have the associated environmental impacts: emissions from the delivery routes, energy for the cold chain and packaging waste are some of the main concerns. The purpose of this paper is to contribute with knowledge to support the development and implementation of circular retail supply chains, wi

Travel and tourism have become an increasingly important sociocultural and economic phenomena in the contemporary globalized world. As an arena in which people and businesses from different countries come into contact, tourism operates within the framework of particular spatial patterns and is closely bound up with issues of foreign policy, international relations, public policy and the exercise o

Background: The rising incidence of melanoma and the high number of benign lesions excised due to diagnostic uncertainty highlight the need for effective patient triage. This study assesses the safety and accuracy of teledermoscopic triage on a high-prevalence case set with pre-triaged, challenging, melanoma-suspicious lesions. Methods: Five dermatologists independently reviewed 250 retrospectivel

Background: Screen time among children and adolescents has increased dramatically, raising concerns about its impact on development and mental health. While research highlights both potential benefits and risks, excessive use has been linked to issues like anxiety, depression, and gaming addiction. Despite growing concern, effective interventions are scarce. Recognizing the importance of family dy

Crystallization-induced stress within confined spaces of porous materials presents significant challenges across various disciplines, including conservation science, geomorphology, geotechnical engineering, and concrete durability. Despite its significance, understanding how localized, transient, and anisotropic stress is generated in pores due to salt crystallization, along with its mechanisms of

Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly through overexpression models that suggest a possible gain of toxic misfunction. However, its effects under endogenous conditions are largely unknown

Tourism research does not exist in a vacuum. It is affected not only by changes in tourism consumption and production, but also wider global events and the shifting priorities and policies of higher education institutions and research funders which have placed a stronger emphasis on assessments research output quality, public-private partnerships and relevance (however defined). The constant fluid

A comprehensive approach to ecological functional zoning in the Shenzhen region of China is presented in this study. Through the integration of advanced geospatial analysis tools, multiple data sources, and sophisticated statistical techniques, different ecological functions have been identified and categorized based on a comprehensive set of indicators and spatial analysis techniques. The three-l

Background Task-sharing of spinal anaesthesia care by non-specialist graduate physicians, termed medical officers (MOs), is commonly practised in rural Indian healthcare facilities to mitigate workforce constraints. We sought to assess whether spinal anaesthesia failure rates of MOs were non-inferior to those of consultant anaesthesiologists (CA) following a standardised educational curriculum. Me

Background Mothers attending prevention of mother-to-child transmission (PMTCT) of HIV clinics seem to lack knowledge on many aspects of PMTCT, among which is breastfeeding. Breastfeeding recommendations in PMTCT have changed several times over the years leaving some confused and doubtful of what is currently recommended. One method shown to help improve their knowledge and acceptance of PMTCT rec

Although its role has been debated, temporal artery biopsy (TAB) remains the gold standard for the diagnosis of cranial giant cell arteritis (GCA). The specificity of TAB is excellent and the sensitivity, albeit lower, is comparable with other diagnostic modalities used for the diagnosis of GCA. This outpatient procedure has a low rate of complications and is well integrated in the majority of hea

Semiconductor nanowires can enhance the signal of fluorescent molecules, thus significantly improving the limits of fluorescence detection in optical biosensing. In this work, we explore how the sensitivity can further be enhanced through "digital"detection of adequately spaced vertically aligned nanowires, employing single-emitter localization methods, and bright-field microscopy. Additionally, w

This guide Addressing Inner Dimensions for Sustainability in Higher Education is aimed at Higher Education faculty from diverse disciplines. The target group is interested in expanding their sustainability knowledge and perspectives, integrating sustainability into their teaching practices, and enhancing their sustainability-related teaching approach by addressing inner dimensions. By inner dimens