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Hepatic steatosis aggravates atherosclerosis via small extracellular vesicle-mediated inhibition of cellular cholesterol efflux

Background & AimsWhile it is recognized that non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD), how NAFLD affects the development and progression of CVD remains unclear and debatable. Hence, we aimed to determine the role of steatotic hepatocyte-derived small extracellular vesicles (sEVs) in foam cell formation and atherosclerosis progression.MethodssEVs

Associations of MAFLD and MAFLD subtypes with the risk of the incident myocardial infarction and stroke

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a condition characterized by liver fat accumulation and metabolic abnormalities. Given the potential impact of MAFLD on patient health, it is important to understand its association with major adverse cardiovascular events (MACE) such as myocardial infarction (MI) and stroke. In the prospective UK Biobank cohort, we sought to elucidat

Nanoparticle emissions from the transport sector : Health and policy impacts - the nPETS concept

Road, rail, air, and sea transport generate a major fraction of outdoor ultrafine particles. However, there is no common methodology for comparable sub 100 nm particle emissions measurement. This paper presents the nPETS (grant agreement No 954377) concept to understand and mitigate the effects of emerging non-regulated nanoparticle emissions. This paper presents the concept and selected results.

Hållbart chefskap i offentlig sektor : Tala, lyssna och reflektera om chefers mående

Denna forskningsrapport sammanfattar resultaten från ett tvåårigt forsknings–projekt om hållbart chefskap i Helsingborgs stad. Det övergripande målet medforskningsprojektet är att bidra med kunskap om hur organisatoriskt stöd i arbetemed chefers hälsa kan och bör utformas. I denna rapport sätter vi särskilt fokus påvad cheferna själva efterfrågar för organisatoriskt stöd samt hur ett sådant stöd k

Parents' lived experience of early risk assessment for cerebral palsy in their young child using a mobile application after discharge from hospital in the newborn period

INTRODUCTION: General Movement assessment (GMA) is considered the golden standard for early identification of infants with a high risk of developing cerebral palsy (CP). The aim of this study was to explore parents' lived experience of early risk assessment for CP using a mobile application for home video recording after discharge from hospital stay in the newborn period.METHODS: An inductive qual

Revisiting the applicability and constraints of molybdenum - and uranium-based paleo redox proxies : comparing two contrasting sill fjords

Sedimentary molybdenum (Mo) and uranium (U) enrichments are often used as redox proxies to reconstruct bottom water redox changes. However, these redox proxies may not be equally reliable across a range of coastal settings due to varying depositional environments. Fjords vary greatly in their depositional conditions, due to their unique bathymetry and hydrography, and are highly vulnerable to anth

Serum biomarkers in patients with hand-arm vibration injury and in controls

Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differenc

Intensivvårdsavdelningarna i Lund och Malmö under Covid-19 : En analys av den organisatoriska responsen och personalens erfarenheter

Rapporten sammanfattar det forskningsprojekt, finansierat av Riksbankens Jubileumsfond, som Rebecca Selberg utfört inom verksamhetsområde intensiv- och perioperativ vård (IPV) vid Skånes universitetssjukhus januari 2021 – juni 2022. Rapporten bygger på djupintervjuer och observationer, samt på en strategisk genomgång av tidigare forskning kring krishantering och covidpandemins effekter på vårdpers

Communication work for influencing destination resilience–DMOs experiences during the COVID-19 pandemic

Previous research has identified good communication as one of several key factors essential for destination resilience. However, there has been a lack of research on how communication contributes to this development. To address this gap, this study explores the communication work done by Destination Management Organizations (DMOs) with stakeholders to influence destination resilience. The study ex

Implementation of Brief Admission by Self-Referral in Child and Adolescent Psychiatry in Sweden : Insights from Implementers and Staff

Brief admission by self-referral, which allows patients to briefly admit themselves to a psychiatric ward, is a crisis intervention designed to reduce suicide and self-harm. This method was introduced in Sweden for adult patients in 2015, achieving high patient satisfaction and good acceptance among staff. In 2018, the method was adapted and implemented in pediatric psychiatry. The present study c

A Mars 2020 Perseverance SuperCam Perspective on the Igneous Nature of the Máaz Formation at Jezero Crater and Link With Séítah, Mars

The Máaz formation consists of the first lithologies in Jezero crater analyzed by the Mars 2020 Perseverance rover. This formation, investigated from Sols (Martian days) 1 to 201 and from Sols 343 to 382, overlies the Séítah formation (previously described as an olivine-rich cumulate) and was initially suggested to represent an igneous crater floor unit based on orbital analyses. Using SuperCam da