Pregnancy planning and genetic testing (PPGT) has emerged as a tool in reproductive healthcare, offering parents-to-be insight in their risks of having a child with a genetic disorder. This paper reviews the advantages, drawbacks and challenges associated with PPGT, providing some practical guidance for health care professionals. Advantages include identification of genetic risks, a possibility to

Background/ Objectives: Research into ANCA-associated vasculitis (AAV) is hampered by the rarity of the disease and thesubsequent small sample sizes of observational cohorts. This is further aggravated by the observational cohorts being containedin fragmented data pools and lacking standardisation to allow for interoperability. FAIRVASC is a Europe-wide research project,which has developed an infr

Objective: To determine if prior exposure to certain drugs is associated with increased risk of ANCA associated vasculitis(AAV).Patients and Method: We performed a population-based case–control study including patients with AAV diagnosed between2006 and 2019 from a defined geographic area in southern Sweden. For each case, we identified 10 controls randomly sampledfrom the background general popul

Background: We hypothesised that observed annual incidence rates of ANCA-associated vasculitis (AAV) are driven bysporadic short-term, high-intensity rates characterised as clusters of diagnosis events in time. Using data from Ireland, Swedenand Spain, we performed a changepoint analysis to discover time intervals with high and low rates of vasculitis diagnosis.Methods: We recruited 417 patients f

Varved lake sediments offer valuable insight into past environmental conditions with high temporal resolution and precise chronological control. A combination of diatom and geochemical analyses of the recently deposited sediments of Odensjön, a small dimictic lake in southern Sweden, shows alternating light and dark laminae composed of greater amounts of biogenic silica and organic matter, respect

Volcanic eruptions are documented throughout geological history and are frequently observed and experienced in the modernworld. Strong eruptions in recent decades have resulted in air and water pollution, acid snowfall, disruption in aerial transport and variousillnesses in humans and livestock. Despite their consequences, these recent events are incomparable to eruptions of a much largermagnitude

This book presents a critical examination of Hume's views on the subject of freedom and moral responsibility. It is widely held that Hume's discussions “Of liberty and necessity,” as presented in both the Treatise and first Enquiry, constitute the classical statement of the “compatibilist” position – the view that freedom and moral responsibility cannot only be reconciled with causation but actual

Although it is widely recognized that David Hume's A Treatise of Human Nature (1739‐40) belongs among the greatest works of philosophy, there is little agreement about the correct way to interpret his fundamental intentions. Among almost all commentators it is an established orthodoxy that skepticism and naturalism are the two dominant themes in this work. The difficulty has been, however, that Hu

Even those who follow the general strategy of P. F. Strawson’s enormously influential “Freedom and Resentment” accept that his strong naturalist program needs to be substantially modified, if not rejected. An important effort to revise the Strawsonian program has been provided by R. Jay Wallace. This chapter argues that Wallace’s narrow construal of reactive attitudes, as they are involved in hold

Although P.F. Strawson and Bernard Williams have both made highly significant and influential contributions on the subject of moral responsibility, they never directly engaged with the views of each other. On one natural reading their views are directly opposed. Strawson seeks to discredit scepticism about moral responsibility by means of naturalistic observations and arguments. Williams, by contr

Recasting Hume and Early Modern Philosophy is a collection of essays that are all concerned with major figures and topics in the early modern philosophy. Most of the essays are concerned, more specifically, with the philosophy of David Hume (1711-1776). The sixteen essays included in this collection are divided into five parts. These parts are arranged under the headings of: (1) Metaphysics and Ep