Adipocytes play a central role in energy balance, and dysfunctional adipose tissue severely affects systemic energy homeostasis. The ATPase EH domain-containing 2 (EHD2) has previously been shown to regulate caveolae, plasma membrane-specific domains that are involved in lipid uptake and signal transduction. Here, we investigated the role of EHD2 in adipocyte function. We demonstrate that EHD2 pro

This paper focuses on the event-based distributed robust leaderless synchronization control for multiple Euler-Lagrange systems with directed communication topology that contains a directed spanning tree. Update frequency of the system is reduced by taking advantages of the event-triggered approach, which can help extend the service life of the controller. Robust control theory is employed to guar

The covalent nature of the low-barrier N−H−N hydrogen bonds in the negative thermal expansion material H 3 [Co(CN) 6 ] has been established by using a combination of X-ray and neutron diffraction electron density analysis and theoretical calculations. This finding explains why negative thermal expansion can occur in a material not commonly considered to be built from rigid linkers. The pertinen

OBJECTIVE: Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy to gain insight into appropriate classification of this diabetes subtype.RESEARCH DESIGN AND METHODS: We performed the first genome-wide association

An ultrahigh-pressure supercritical fluid extraction method was optimized and applied to extract seed oil lipids from two moringa species, namely Moringa oleifera (MO) and Moringa peregrina (MP). A full-factorial design was used to investigate the direct and interaction influence of pressure and temperature in the range of 40 to 80 MPa and 40 to 70 °C, respectively, on the extracted amount of oil

This paper examines cultural practices by contemporary creative collectives in two creative cities in Southeast Asia: George Town in Malaysia and Bandung in Indonesia. The aim is to address the tensions within the narrative branding of these post-colonial cities and the disruption of this narrative through everyday tactics of creative collectives who are rendered silent and unnoticed. The analysis

Technological advances have made possible industrial and commercial applications of artificial intelligence, virtual reality and highly integrated manufacturing systems. It has also freed business activity from a focus on place, as both work activities and markets have been able to harness information and communication technologies in order to operate remotely. As a result, researchers have highli

Background: The aim was to identify and characterize rare malignancies of the gallbladder, incidentally found at cholecystectomy, and describe the diagnostic work-up, treatment and outcome. Methods: Data from cholecystectomies during 2007–2014 registered in the Swedish Register for Gallstone Surgery (GallRiks) were analyzed for incidental cancer. For completion of the pathology report, data were l

Wildland-urban interface (WUI) fire incidents are likely to become more severe and will affect more and more people. Given their scale and complexity, WUI incidents require a multidomain approach to assess their impact and the effectiveness of any mitigation efforts. The authors recently produced a specification for a simulation framework that quantifies evacuation performance during WUI incidents

BackgroundWe introduce and apply an elegant, contrastive genetic-epidemiological design - Maternal Half-Sibling Families with Discordant Fathers - to clarify cross-generational transmission of genetic risk to alcohol use disorder (AUD), drug abuse (DA) and major depression (MD).MethodUsing Swedish national registries, we identified 73 108 eligible pairs of reared together maternal half-siblings an

A total of 462 coprolites from three localities exposing Upper Cretaceous deposits in the Münster Basin, northwestern Germany, have been subjected to an array of analytical techniques, with the aim of elucidating ancient trophic structures and predator–prey interactions. The phosphatic composition, frequent bone inclusions, size and morphology collectively suggest that most, if not all, coprolites

We introduce a comprehensive framework for the efficient implementation of finite deformation gradient-regularised damage formulations in existing finite element codes. The numerical implementation is established within a thermo-mechanically fully coupled finite element formulation, where the heat equation solution capabilities are utilised for the damage regularisation. The variationally consiste

A composite Higgs boson is likely to be accompanied by additional light states generated by the same dynamics. This expectation is substantiated when realizing the composite Higgs mechanism by an underlying gauge theory. We review the dynamics of such objects, which may well be the first sign of compositeness at colliders. We also update our previous analysis of the bounds from LHC searches to the

Background: The aim of this study was to identify predictors of outcome after septoplasty in 888 patients from the Swedish National Septoplasty Register. Methodology: This is an observational register study analysing data from patients undergoing septoplasty in Sweden between 2015 and 2016. The patients reported severity of nasal obstruction (mild, moderate, severe) pre- and again 12 months postop

Objective: In patients with myocardial infarction (MI), risk factors for bleeding and ischaemic events tend to overlap, but the combined effects of these factors have scarcely been studied in contemporary real-world settings. We aimed to assess the combined associations of established risk factors using nationwide registries. Methods: Using the Swedish Web-system for Enhancement and Development of

Following Emily Wardill's exhibition "Matt Black and Rat" at Bergen Kunsthall, January 20th to March 26th 2017, the publication Things Keep Their Secrets, is an extensive and multi-faceted work which includes both images and stills from the artist's latest works, the unique fumages, manually inserted into each of the 750 copies – as well as two newly commissioned texts by philosopher Michael Marde

- Field data on breeding phenology of Ranaarvalis and R.temporaria for the period 1990- 2017 in Scania, Sweden are presented and analysed. There was no temporal trend for R.temporaria. ForR.arvalisthe results were mixed, one out of two approaches found a trend to earlier breeding. The lack of a consistent trend in breeding phenology is unsurprising considering that local mean air temperatures in F