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The thermostable β-glucosidase from Thermotoga neapolitana, TnBgl3B, is a monomeric three-domain representative from glycoside hydrolase family 3. By using chemical reactivation with exogenous nucleophiles in previous studies with TnBg13B, the catalytic nucleophile (D242) and corresponding acid/base residue (E458) were determined. Identifying these residues led to the attempt of converting TnBgl3B

Decision making and requirements scoping occupy central roles in helping to develop products that are demanded by the customers and ensuring company strategies are accurately realized in product scope. Many companies experience continuous and frequent scope changes and fluctuations but struggle to measure the phenomena and correlate the measurement to the quality of the requirements process. We pr

Oligodendrocyte (OL) death may contribute to white matter pathology, a common cause of network dysfunction and persistent cognitive problems in patients with traumatic brain injury (TBI). Oligodendrocyte progenitor cells (OPCs) persist throughout the adult CNS and may replace dead OLs. OL death and OPCs were analyzed by immunohistochemistry of human brain tissue samples, surgically removed due to

Eating disorders (EDs) are common and serious psychiatric disorders causing significant physical and psychological suffering, for both those afflicted and their significant others. Although there has been considerable research on EDs throughout the years, there is still much left to be desired for successful treatment.Perfectionism has been suggested to play a crucial role in the development and m

Rubinstein–Taybi syndrome (RSTS) is a developmental disorder characterized by a typical face and distal limbs abnormalities, intellectual disability, and a vast number of other features. Two genes are known to cause RSTS, CREBBP in 60% and EP300 in 8–10% of clinically diagnosed cases. Both paralogs act in chromatin remodeling and encode for transcriptional co-activators interacting with >400 prote

Background:Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of

Since the 1990s, the low number of students choosing to study science and technology in higher education has been on the societal agenda and many initiatives have been launched to promote awareness regarding career options. The initiatives particularly focus on increasing enrolment in the engineering programmes. This article describes and compares eight European initiatives that have been establis

This document presents the results of a literature review performed in order to assess the suitability of different evacuation modelling tools for the calculation of evacuation times and assessment of fire safety in underground physics research facilities. This document is part of the research collaboration between Lund University and the European Organization for Nuclear Research (CERN), concerni

Evacuation models used in fire safety engineering have largely expanded their capabilities over the last decades. They started as simple computational tools in which people movement equations were implemented in discrete spaces, while they now often allow the simulation of complex behaviours and decision making through advanced agent-based simulation techniques in three-dimensional environments. W

The aim of the study was to compare users of community-based mental health day centres (DCs) and clubhouses in Sweden regarding reported social networks and social interaction and the stability of these over time. A further aim was to investigate social network predictors both cross-sectionally and longitudinally.