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Halogen substituents often lead to a profound effect on the biological activity of organic compounds. Flavin-dependent halogenases offer the possibility of regioselective halogenation at non-activated carbon atoms, while employing only halide salts and molecular oxygen. However, low enzyme activity, instability, and narrow substrate scope compromise the use of enzymatic halogenation as an economic
This article examines the idea of degrowth, a concept in political ecology used to envision a democratically planned downscaling of production and consumption in affluent regions of the world as a means to avoid ecological breakdown, decrease inequality, and improve quality of life. Since its inception at the beginning of the 2000s in France, the idea of degrowth has sparked a worldwide social mov
The purpose of this study is to explore the concept of social acceleration by examining how cities are trying to speed up, maintain or slow down the pace of societal change. Through studies of cycle logistics policies and actions in cities in Denmark, Norway, the UK, the Netherlands, and Germany, we show how these balance between acting as pace-makers and pace-takers, as well as what the consequenThe purpose of this study is to explore the concept of social acceleration by examining how cities are trying tospeed up, maintain or slow down the pace of societal change. Through studies of cycle logistics policies andactions in cities in Denmark, Norway, the UK, the Netherlands, and Germany, we show how these balance be-tween acting as pace-makers and pace-takers, as well as what the consequenc
Meeting the goals set out in the Paris Agreement will require rapid and deep reductions of greenhouse gas emissions (GHG) across all sectors of the global economy. Like all major societal transformations, this climate transition will impact both social and technical aspects of society and, depending on how it evolves, will reallocate social and economic benefits and costs differently. Recognising
[4Fe–4S] clusters are essential cofactors in many proteins involved in biological redox-active processes. Density functional theory (DFT) methods are widely used to study these clusters. Previous investigations have indicated that there exist two local minima for these clusters in proteins. We perform a detailed study of these minima in five proteins and two oxidation states, using combined quantu
Den här boken behandlar offentlig upphandling från ett juridiskt och ett nationalekonomiskt perspektiv. Bokens disposition följer i princip upphandlingsprocessen, från behovsidentifiering till avtalsslut. Inledningsvis diskuteras när det är lämpligt att ersätta verksamhet i egen regi med upphandling. Därefter går boken in på hur offentlig upphandling ska genomföras, inom de ramar som ges av regelv
Background & aims: Despite advances in the management of short bowel syndrome related intestinal failure (SBS-IF), large-scale contemporary pediatric studies are scarce. The aim of this multicenter study was to assess key outcomes and clinical prognostic factors in a recent Nordic pediatric SBS-IF population. Methods: Patients with SBS-IF treated during 2010–2019, whose parenteral support (PS)
Ansvaret för att tillhandahålla välfärdstjänster i Sverige ligger i huvudsak på kommuner, landsting och regioner. Det gäller bland annat tillgång till bostäder, hälso- och sjukvård, avfallshantering och utbildning.Utförandet är dock ofta en uppgift för privata aktörer, vilket innebär att det EU-rättsliga regelverket aktualiseras. I den här rapporten diskuterar professor Tom Madell vilken betydel
The use of municipally owned corporations (MOCs) has a long tradition in Sweden. In this chapter we take the point of departure in this long tradition of MOCs when describing how the use of these corporations has developed over time as well as the conditions under which these MOCs operate has developed. In addition, some of the more problematic features of MOCs, that Swedish local governments stru
Helminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb have long been ranked as the number one single infectious agent claiming the most lives. The only licensed vaccine for TB (BCG) offers highly variable protection against TB, and almost no pro
