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Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individ
Discrepancies in views of the Self are suggested to be negatively related to well-being (Higgins, 1987). In the present study, we used a novel concept, Personality Estimation Discrepancy (PED), to test this classic idea. PED is defined as the computed difference between how one view oneself (Self-Perceived Personality) and a standard Big Five test (IPIP-NEO-30). In a pre-registered (osf.io) UK onl
We consider a numerical approximation of a linear quadratic control problem constrained by the stochastic heat equation with nonhomogeneous Neumann boundary conditions. This involves a combination of distributed and boundary control, as well as both distributed and boundary noise. We apply the finite element method for the spatial discretization and the linear implicit Euler method for the tempora
Ramjet propulsion is commonly preferred to power supersonic and hypersonic vehicles for cruising faster than Mach 3. This is an elegant solution owing to the lean architecture which does not embody any rotating parts. Although the geometry of the engine is simple as compared to turbine based configurations, the flow physics through the engine duct is quite complex and the flow speeds modulate betw
We describe the design and implementation of a new constraint programming solver that can produce an auditable record of what problem was solved and how the solution was reached. As well as a solution, this solver provides an independently verifiable proof log demonstrating that the solution is correct. This proof log uses the VeriPB proof system, which is based upon cutting planes reasoning with
Social norms guide humans’ everyday behavior, and previous research has shown that social norms consistently predict some forms of political participation. Failure to conform to norms may lead to deviation and possible rejection, which humans innately seek to avoid since it threatens their need for belongingness. Following an episode of rejection, individuals are therefore likely to become increas
In particle collider experiments, elementary particle interactions with large momentum transfer produce quarks and gluons (known as partons) whose evolution is governed by the strong force, as described by the theory of quantum chromodynamics (QCD)1. These partons subsequently emit further partons in a process that can be described as a parton shower2, which culminates in the formation of detectab
Background: Pancreatic ductal adenocarcinoma is a highly fatal malignancy. The aim was to identify preoperative factors for early mortality in up-front resectable patients following pancreatoduodenectomy (PD) and develop an early mortality risk score. Methods: Patients registered in the Swedish National Registry for Pancreatic and Periampullary Cancer were included. Relevant preoperative factors (
The historical subclassification of diabetes into predominantly types 1 and 2 is well appreciated to inadequately capture the heterogeneity seen in patient presentations, disease course, response to therapy and disease complications. This review summarises proposed data-driven approaches to further refine diabetes subtypes using clinical phenotypes and/or genetic information. We highlight the bene
A new combination, Nephromopsis annae (Oxner) A.Thell & Divakar is proposed and the basionym Cetrariasubalpina Imshaug is preferred over the combination in Nephromopsis.
The COVID-19 pandemic, climate crisis, and a shifting geopolitical landscape present us with strategic, ethical and planetary dilemmas that demand more reflective action on behalf of actors at every level. The identified challenges of the not-so-distant future require a fundamental transformation of how companies do business, and the role of business schools in shaping the business practices of th
Encounters between patients in homecare and nursing students are cultural events where students, in principle, are in unknown territory. This study illuminated how nursing students recount (inter)actions in social relations in Danish homecare settings, illustrated by students with a self-appointed immigrant background. The study consisted of semi-structured interviews with eight nursing students.
There is a vivid interest in so-called epimilitary narratives of war that depart from heroic themes and zoom out from the armed forces. This article joins this direction by analyzing two variants of cultural narratives of the war in Bosnia-Hercegovina during the 1990s and the siege of Sarajevo: the videogame This War of Mine and Bosnian citizens’ personal stories told in qualitative interviews. BoThere is a vivid interest in so-called epimilitary narratives of war that depart from heroic themes and zoom out from the armed forces. This article joins this direction by analyzing two variants of cultural narratives of the war in Bosnia-Hercegovina during the 1990s and the siege of Sarajevo: the videogame This War of Mine and Bosnian citizens’ personal stories told in qualitative interviews. Bo
Grocery retail is going through a rapid shift. Consumers now expect to be able to shop online or in stores, get orders delivered when and where they want, and preferably as quickly as possible. This development is called omnichannel and means grocery retailers must transform their logistics networks to meet consumers’ evolving expectations and demands. The omnichannel transformation includes, for Grocery retail is going through a rapid shift. Consumers now expect to be able to shop online or in stores, get orders delivered when and where they want, and preferably as quickly as possible. This development is called omnichannel and means grocery retailers must transform their logistics networks to meet consumers’ evolving expectations and demands. The omnichannel transformation includes, for
Spark ablation is an established method for generating aerosol nanoparticles. By changing the electrodes, synthesis of monometallic, multimetallic and semiconducting nanoparticles has been demonstrated. Apart from using electrodes of specific composition, compositional tuning of bimetallic nanoparticles during synthesis has recently been demonstrated (Kohut, et al., 2021). In many applications, it
Material quality, and opportunities for multiple reprocessing, need to be considered when analysing the overall carbon footprint and energy efficiency of plastic products in life cycle assessments. This is rarely done today. This paper presents a case study evaluating a closed-loop recycling system involving a plastics manufacturer in Sweden which produces and reprocesses multiple-use plastic dini
INTRODUCTION Globally, 20% of women who become pregnant are obese at the time of conception. The prevalence of women becoming pregnant after gastric bypass (GBP) surgery has been increasing. Little is known regarding women’s experiences of pregnancy after GBP surgery and midwives can expect to care for an increasing number of women with prior GBP surgery. Midwives play an important role in support
