Sökresultat

Purpose: High-dose methotrexate (HDMTX) is a cornerstone in pediatric oncology, but delayed methotrexate elimination (DME) can cause severe toxicity. Rescue therapy typically combines folinic acid (FA) and glucarpidase (GP), yet current guidelines recommend pausing FA around GP administration due to presumed interference. This study aimed to determine whether FA affects GP efficacy in metabolizing

In this work, we explored the catalytic decomposition of methanol to syngas at 300 °C using intermetallic Ni3Sn2 nanoparticles (NPs) synthesized via a chemical route. Our study employed a comprehensive approach combining operando Ambient Pressure soft X-ray absorption spectroscopy with a suite of ex situ techniques─including X-ray diffraction, X-ray photoelectron spectroscopy, electron microscopy,

Road verges resemble natural bumblebee habitats in terms of flowers and nesting substrates. Hence, they may benefit bumblebee populations, especially in landscape where other floral and nesting resources are scarce. Such benefits may, however, be offset by the adjacency to traffic. As bumblebees move between habitat patches, effects on populations may manifest across landscapes rather than in the

Richard Swedberg has put the theme of “theorizing” on the international sociological agenda. The article begins by exploring the surprising parallels that can be found between Swedberg's The Art of Social Theory and the work of the Romantic writer Friedrich von Hardenberg. The thesis is that the latter's ideas about poeticization, the Romantic operation, the art of invention, experimentation, and

Ammonia is a promising carbon-free fuel for internal combustion engines (ICEs). However, existing research has not yet provided satisfactory solutions for ammonia combustion, a crucial gap that significantly limits its practical application. In this study, ammonia thermal atmosphere compression ignition (TACI) combustion mode was proposed as a promising solution to achieve efficient and clean ammo

BACKGROUND: Discordance between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFR) has been linked to adverse outcomes. A low eGFRcys/eGFRcr-ratio, conceptualized as selective glomerular hypofiltration syndrome (SGHS), has been hypothesized to reflect early metabolic kidney vulnerability, although non-glomerular filtration rate determinants may also contribute. We investi

Social support is important for human well-being. Adolescents with experience of out-of-home care (OHC) have an increased risk of low well-being and lack of strong social support networks. Well-being in the general population is known to fluctuate during the life-course, particularly during adolescence. The purpose of this study was to increase our understanding of how well-being differs at differ

Take Home Message Lymph node–positive renal cell carcinoma is a heterogeneous condition. Patients with bulky or multiple nodal metastases often behave like those with metastatic disease and may benefit more from upfront systemic therapy than from surgery alone.

In this work, the electrical performance of fully vertical single-fin a-plane gallium nitride fin-based field-effect transistors (FinFETs) with short gate length (Lg≈ 200nm) and a drift-layer thickness of 4.3 µm is investigated. Device characteristics are evaluated over a temperature range from 25 °C to 150 °C for various fin widths. The FinFETs exhibit stable normally-off operation across the ent

Involving the local community in the late stages of a project offers minimal opportunity for influencing decision-making. Therefore, project managers must act early and establish arenas for participation where dialogue and learning can take place. Early involvement through stakeholder participation can be a way to involve the local community in the early stages of urban regeneration projects. A co

Aims Left ventricular (LV) function is enhanced during exercise in endurance-trained (ET) compared to untrained (UT) healthy individuals. However, the volume responses of the right ventricle (RV), left atrium (LA), and right atrium (RA) during exercise have not been studied in the same subject simultaneously and while standardizing for the respiratory influence on cardiac volumes. The aim was ther

Independent-living senior housing (ILSH) is viewed as a promising housing alternative for promoting active aging, yet evidence remains limited on how spatial design and programming support social engagement. This study examined residents’ use of common spaces, evaluations of community programs, and perceived social opportunities in affordable ILSH. A three-site case study in Metro Boston used mixe

Aim: To investigate at a national level the multidisciplinary team (MDT) care of patients with diabetes mellitus and foot complications.Methods: A questionnaire was sent to all 75 Swedish hospitals with emergency departments, which were grouped according to size.Results: The response rate was 92%, 58/69 of the hospitals have a foot team. Most teams have access to an internal medicine specialist/di

AIMS: Osteoarthropathy, a rare foot complication in patients with diabetes mellitus, calls for immediate and optimal management to prevent irreversible bone/joint destruction and risk of amputation. Awareness of the condition and adequate guidelines would minimize the consequences and the costs, both for the patient and for the society. We investigated the diabetic osteoarthropathy care in Swedish

Introduction: Restoration of surgical capacity is essential to post-COVID-19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of health systems.Methods: This is a secondary analysis of an international prospective cohort study of conse

Marco Polos klassiska reseskildring har gjort honom till en av tidernas stora resenärer. Med avfärd 1271 tog sig den unge venetianaren, tillsammans med far och farbror, över Asiens väldiga landmassa ända till Kina, kom i mongolhärskarens tjänst och återvände inte till sitt hemland förrän 1295 – där det hände sig att han togs som krigsfånge av det rivaliserande Genua. Och det var där, i fångenskape

This essay celebrates Professor Johannes Müller and his promotion of novel studies of inequality in the past. Here we reconsider the formation of the Nordic Bronze Age and the frictions that arose when a strong collective tradition was challenged by the new opportunities for individual enrichment available in a global bronze-led network, from c. 2100 BCE. What impact did this have on the scale of