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BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) of 0.02 or greater in the absence and presence of cytopenia, respectively. CHIP/CCUS is highly prevalent in adults, and defining predictors of MN risk would aid
Aims. We aim to refine the fundamental parameters of the TOI-2141 planetary system, which includes a transiting sub-Neptune orbiting a Sun-like star on a relatively long orbit of 18.26 days, by combining new photometric and spectroscopic observations. Methods. We analyzed new space-based photometry from TESS and CHEOPS, as well as 61 radial velocity measurements from HARPS-N. We performed individu
Infections caused by anaerobes are common in children. However, limited data are available on bloodstream infections caused by these bacteria in Europe. A multicentre retrospective observational study was conducted over a 4-year period (2020–2023) across 44 European hospitals to analyze all anaerobes isolated from blood cultures. The study examined the epidemiology and antimicrobial resistance pro
När föräldrar har låga inkomster minskar barnens möjligheter att exempelvis resa på semester eller delta i fritidsaktiviteter som kostar pengar. Att växa upp i ekonomisk utsatthet kan påverka barns framtidsutsikter negativt. Av den offentliga statistiken vet vi att barnfattigdom är vanligare bland familjer med utrikes födda föräldrar, men variationen inom gruppen är stor och delvis outforskad.I de
Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease type (invasive breast cancer, DCIS), and risk threshold. Methods: In a retrospective case–control study, we evaluated risk prediction performance in 180,398 women (
This study concerns democracy in education examined through the lens of small-group instrumental teaching. Traditionally, one-to-one teaching in a master–apprentice approach has been the established norm for instrumental teaching and the same model has long characterised instrumental teaching in Sweden’s art and music schools (SAMSs, kulturskolor).1 However, although individual teaching is still t
Objective: The aim of this study was to achieve an international expert consensus on managing acute type B penetrating aortic ulcers (PAUs) and intramural haematomas (IMHs). Methods: A modified Delphi consensus process was employed to develop recommendations for the management of acute type B PAU and IMH. Surveys were sent to international experts practicing in high volume aortic centres worldwide
Den omvälvande förändring som banade väg för det som kommit att kallas kunskapsekonomin har lett till en omfattande avindustrialisering av de regionala ekonomierna. Den har omformat grundvalarna för de lokala arbetsmarknaderna och förändrat riktningen i den regionala ojämna utvecklingen och löneskillnaderna. Mycket av den akademiska debatten har dock antingen grundats i nationella studier av lönesThe transformational change that ushered in what became known as the knowledge economy has led to widespread deindustrialisation of regional economies. It has reshaped the foundations of local labour markets and shifted the momentum of regional uneven development and wage inequalities. Much of the academic debate, however, has either been grounded in national-level studies of wage disparities or f
Understanding the basic biology of both a host and the pathogens they are afflicted by is a prerequisite for the development of effective clinical interventions. Mycobacterium tuberculosis, the causative agent of tuberculosis, remains one of the leading causes of disease worldwide. Despite extensive research, the appearance of highly drug-resistant bacterial strains and the prevalence of HIV co-in
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomi
This paper examines how violent conflict affects the supply of education in one of the world’s poorest countries, Burkina Faso. We combine unique nationwide census data on all primary schools with geocoded records of Islamist violence to assess how local conflict exposure shapes school availability, staffing, and the mix of education provision. Using a staggered difference-in-differences design anThis paper examines how violent conflict affects the supply of education in one of the world’s poorest countries, Burkina Faso. We combine unique nationwide census data on all primary schools with geocoded records of Islamist violence to assess how local conflict exposure shapes school availability, staffing, and the mix of education provision. Using a staggered difference-in-differences design an
This paper examines whether and how Islamist violence affects educational content in secondary schools in Burkina Faso. We combine geocoded conflict-event data with nationwide school census data containing detailed information on teachers’ subject-specific teaching hours and mobility across schools. Using a staggered difference-in-differences design, we estimate the dynamic effects of violence on This paper examines whether and how Islamist violence affects educational content in secondary schools in Burkina Faso. We combine geocoded conflict-event data with nationwide school census data containing detailed information on teachers’ subject-specific teaching hours and mobility across schools. Using a staggered difference-in-differences design, we estimate the dynamic effects of violence on
BACKGROUND: Several studies have sought to investigate gambling craving and its potential contribution to gambling problems. One aim of this line of research has been to further examine whether craving should be considered a separate diagnostic criterion for gambling disorder, which it currently is not. The present study aimed to investigate the relationship between craving and other risk factors—
ObjectiveDopaminergic medications are commonly prescribed for Parkinson's disease (PD), restless legs syndrome, pituitary and psychotic disorders. Accumulating evidence indicates that dopaminergic treatment triggers impulsive-compulsive behaviors (ICBs), yet systematic synthesis of clinical evidence remains limited.MethodThis scoping review summarizes original research directly clinically relevant
OBJECTIVE: It is unknown how risk factors for infection after transrectal prostate biopsy interact. We designed a study to evaluate this.METHODS: We identified biopsy procedures from 2006 to 2020 in the Swedish nationwide database PCBaSe. Primary outcome was post-biopsy infection, defined as a dispensed prescription of a urinary tract antibiotic and secondary outcome was inpatient care for infecti
ImportanceGuidelines for temperature control following out-of-hospital cardiac arrest (OHCA) are based on trials with end points of 180 days or fewer.ObjectivesTo investigate if targeted hypothermia, compared with targeted normothermia with early treatment of fever, affects functional outcome focusing on societal participation or cognitive functioning at 24 months in initially comatose OHCA survivImportanceGuidelines for temperature control following out-of-hospital cardiac arrest (OHCA) are based on trials with end points of 180 days or fewer.ObjectivesTo investigate if targeted hypothermia, compared with targeted normothermia with early treatment of fever, affects functional outcome focusing on societal participation or cognitive functioning at 24 months in initially comatose OHCA surviv
OBJECTIVES: Implementation of the Stroke Action Plan for Europe (2018-2030) (SAP-E) was initiated in 2019. It is now updated at mid-term to reflect and respond to challenges for stroke care in Europe in 2025. METHODS: The SAP-E covers the entire chain of stroke care. The sections (state of the art, current status and targets) were developed by working groups and finalised based on inputs from the
